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Clinical Pharmacology of Antianginal Drugs pp 287–364Cite as

Organic Nitrates

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 76))

Abstract

The following should be understood as a supplement to the excellent review of organic nitrates in Vol. 40 of this handbook which was edited in 1975 by P. Needleman. For this reason, literature older than 1974 which has already been covered by that volume is only used here when necessary. In the same way, topics such as historical background, chemistry and physicochemical properties or side effects of organic nitrates, which naturally have remained constant since then, are not referred to. Although some progress has been achieved in the difficult field of bioanalysis of organic nitrates in recent years, limited space does not allow discussion of this important matter. Sect. B in particular should be read in the context of the earlier chapter on biotransformation of organic nitrates by NEEDLEMAN (1975). Generally, special attention has been given to topics where the experimental evidence accumulated in the meantime has not confirmed the previous views of the authors of Vol. 40, such as enteral activity of organic nitrates, therapeutic value of so-called long-acting nitrates; or where our knowledge has been extended, for instance, the relation between pharmacokinetics and effect, some aspects of the mechahism of action and the development of isosorbide-5-mononitrate for the prophylactic treatment of angina pectoris. Because of the recently revived discussion of nitrate tolerance, a special section has been devoted to this problem, although some redundancy within the later sections on clinical usage was unavoidable.

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Authors
  1. U. Abshagen
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  1. Boehringer Mannheim GmbH, Sandhofer Straße 116, D-6800, Mannheim 31, Germany

    Ulrich Abshagen (Leiter Produktentwicklung Therapeutica) (Leiter Produktentwicklung Therapeutica)

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Dedicated with gratitude to Professor Dr. Helmut Kewitz on the occasion of his 65th birthday

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© 1985 Springer-Verlag Berlin Heidelberg

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Abshagen, U. (1985). Organic Nitrates. In: Abshagen, U. (eds) Clinical Pharmacology of Antianginal Drugs. Handbook of Experimental Pharmacology, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69524-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-69524-7_10

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