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The Surfactant System of the Lung

  • Chapter
Toxicology of Inhaled Materials

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 75))

Abstract

Pulmonary surfactant is the surface tension lowering material which lines the lung alveoli and prevents their collapse on expiration. Its existence was first postulated on theoretical grounds by von Neergard (1929), but it was not actually demonstrated until some 30 years later when Pattle (1955) found that remarkably stable bubbles were expressed from a lung cut under water and Clements (1957) showed that lung extracts lowered surface tension at an air-water interface.

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Authors
  1. S. A. Rooney
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Editors and Affiliations

  1. Toxicology, Biology Division, Oak Ridge National Laboratory, P.O. Box Y, 37831, Oak Ridge, TN, USA

    Hanspeter Witschi M.D. (Section Head) (Section Head)

  2. Department of Environmental Science and Physiology, Harvard University School of Public Health, 665 Huntington Ave., 02115, Boston, MA, USA

    Joseph D. Brain S.D. in Hyg. (Professor of Physiology, Director, Respiratory Biology Program) (Professor of Physiology, Director, Respiratory Biology Program)

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© 1985 Springer-Verlag Berlin Heidelberg

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Rooney, S.A. (1985). The Surfactant System of the Lung. In: Witschi, H., Brain, J.D. (eds) Toxicology of Inhaled Materials. Handbook of Experimental Pharmacology, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69521-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-69521-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69523-0

  • Online ISBN: 978-3-642-69521-6

  • eBook Packages: Springer Book Archive

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