The Design and Operation of Systems for Inhalation Exposure of Animals

  • R. T. Drew
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 75)


The need to assess health effects of airborne chemicals has caused the evolution of a variety of inhalation exposure systems. The development has proceeded in two directions: constructing chambers for immersion of the whole animal in a cloud of the test agent (whole body exposure systems), and building systems that limit the exposure to the head or nose or, in some cases, to a smaller portion of the respiratory tract (hereinafter referred to as limited exposure systems). This chapter will describe the design of both simple and complex whole body exposure systems, outline some of the standard operational procedures, including calibration, review the development of head and nose exposure systems, and describe some of the advantages and potential problems of operating limited exposure systems. The subject is restricted to exposure systems since methods for generation and characterization of particles and vapors are covered elsewhere in this book. Three books have appeared on this subject in the last 5 years (Drew 1978; Willeke 1980; Leong 1981), and for additional reviews the reader is referred to Fraser et al. (1959), Drew and Laskin (1973), Phalen (1976), and Lippmann (1980).


Exposure System Test Agent Inhalation Exposure Brookhaven National Laboratory Exposure Chamber 
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© Springer-Verlag Berlin Heidelberg 1985

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  • R. T. Drew

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