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Antiepileptic Drugs pp 199–243Cite as

Chemical Constitution and Pharmacological Effect

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

It is generally approved that there is a further need for more selective and less toxic antiepileptic drugs (Krall et al. 1978 a, b). In the search for optimal designs for new drugs, medicinal chemists and pharmacologists would benefit from consideration of the rules which emerge from comparison of the structures of active and inactive compounds. It is therefore the aim of this chapter to give an impression of structure-activity relationships mainly of those classes of compounds which include well-known antiepileptic drugs. In general the specification of anticonvulsant activity will be restricted to data from electroshock and pentylenetetrazol-induced shock tests.

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  1. H. Schäfer
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  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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Schäfer, H. (1985). Chemical Constitution and Pharmacological Effect. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_9

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