• K. Wiśniewski
  • H.-H. Frey
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 74)


Prostaglandin (PG) F in ox brain was the first PG to be discovered (SAmuelsson 1964). The occurrence of PGs in the brain of man and different animal species was confirmed in the following years by several groups (Bergstrom and Samuelsson 1965; Horton and Main 1967; Wolfe et al. 1967; Kataoka et al. 1967; Holmes and Norton 1968a,b; Wolfe et al. 1976c): PGE1 PGE2, PGF, PGF, and thromboxane B2 were all identified.


Anticonvulsant Effect Tonic Extension Convulsant Effect Lysine Acetylsalicylate Proconvulsant Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bergström S, Samuelsson B (1965) Prostaglandins. Ann Rev Biochem 34: 101–108Google Scholar
  2. Bhattacharya SK, Sanyal AK (1978) Inhibition of pentylenetetrazole-induced convulsions in rats by prostaglandin E1 role of brain monoamines. Psychopharmacology 56: 235–237PubMedCrossRefGoogle Scholar
  3. Bradley PB, Samuels GMR, Shaw JE (1969) Correlation of prostaglandin release from the cerebral cortex of cats with electro-corticogram following stimulation of the reticular formation. Br J Pharmacol 37: 151–157PubMedGoogle Scholar
  4. Climax J, Sewell RDE (1981) Modification of convulsive behaviour and body temperature in mice by intracerebroventricular administration of prostaglandins, arachidonic acid and the soluble acetylsalicylic acid salt lysine acetylsalicylate. Arch Int Pharmacodyn Ther 250: 254–265PubMedGoogle Scholar
  5. Coceani F, Wolfe LS (1965) Prostaglandins in brain and the release of prostaglandin-like compounds from the cat cerebellar cortex. Can J Physiol Pharmacol 43: 445–450PubMedCrossRefGoogle Scholar
  6. Coceani F, Puglisi L, Lavers B (1971) Prostaglandins and neuronal activity in spinal cord and cuneate nucleus. Ann NY Acad Sci 180: 289–301PubMedCrossRefGoogle Scholar
  7. Duru S, Tiirker RK (1969) Effect of prostaglandin E1 on the strychnine-induced convulsion in the mouse. Experientia 25: 275–277PubMedCrossRefGoogle Scholar
  8. Förstermann V, Heldt R, Knappen E, Hertting G (1982) Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain. Brain Res 240: 303–310PubMedCrossRefGoogle Scholar
  9. Folco GC, Longiave D, Bosisio E (1977) Relations between prostaglandin E2, F2α and cyclic nucleotides. Levels in rat brain and induction of convulsions. Prostaglandins 13: 893–900Google Scholar
  10. Galli C, Spagnuolo C, Petroni A (1980) Factors affecting brain prostaglandin formation. Adv Prostaglandin Thromboxane Res 8: 1235–1239PubMedGoogle Scholar
  11. Hedqvist P (1973) Autonomic neurotransmission. In: Ramwell PW (ed) The prostaglandins, vol 1. Plenum, New York, pp 101–131Google Scholar
  12. Hinman JW (1972) Prostaglandins. Ann Rev Biochem 41: 161–178Google Scholar
  13. Holmes SW (1970) The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release. Br J Pharmacol 37: 635–658Google Scholar
  14. Holmes SW, Horton EW (1968 a) The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system. J Physiol (Lond) 195: 731–741Google Scholar
  15. Holmes SW, Horton EW ( 1968 b) Prostaglandins and the central nervous system. In: Ramwell PW, Shaw JE (eds) Worcester symposium on prostaglandins. Wiley, New York, pp 21–36Google Scholar
  16. Horton EW (1969) Hypothesis on physiological roles of prostaglandins. Physiol Rev 49: 152–161Google Scholar
  17. Horton EW (1972) Prostaglandins. Monographs on endocrinology, vol 7. Springer, Berlin Heidelberg New York, pp 117–149Google Scholar
  18. Horton EW, Main JHM (1967) Identification of prostaglandins in central nervous tissues of the cat and chicken. Br J Pharmacol 30: 582–602Google Scholar
  19. Kataoka K, Ramwell PW, Jessup S (1967) Prostaglandins: localization in subcellular particles or rat cerebral cortex. Science 157: 1187–1189PubMedCrossRefGoogle Scholar
  20. Kroner EE, Peskar BA (1976) On the metabolism of prostaglandins by rat brain homogenate. Experientia 32: 1114–1115PubMedCrossRefGoogle Scholar
  21. Lyneham RC, Low PA, McLeod JG, Shearman RP, Smith ID, Korda AR (1973) Convulsions and electroencephalogram abnormalities after intraamniotic prostaglandin F2α. Lancet II: 1003–1005Google Scholar
  22. Pace-Asciak CR, Rangaraj G (1976 a) Prostaglandin biosynthesis and catabolism in the developing fetal sheep brain. J Biol Chem 251: 3381–3385Google Scholar
  23. Pace-Asciak CR, Rangaraj G (1976 b) Distribution of prostaglandin biosynthetic pathways in organs and tissues of fetal lamb. Biochim Biophys Acta 528: 512–514Google Scholar
  24. Poddubiuk ZM (1976) A comparison of the central actions of prostaglandins A1? E1 E2, F10α and F2α in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat. Psychopharmacology 50: 89–94PubMedCrossRefGoogle Scholar
  25. Poddubiuk ZM, Kleinrok Z (1976) A comparison of the central actions of prostaglandins A1? E1? E2, F1α and F2α in the rat. Psychopharmacology 50: 95–102PubMedCrossRefGoogle Scholar
  26. Potts WJ, East PF, Mueller RA (1974) Behavioral effects. In: Ramwell P (ed) Prostaglandins, vol 2. Plenum, New York, pp 157–173Google Scholar
  27. Ramwell PW, Shaw JE (1966) Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats. Am J Physiol 211: 125–134PubMedGoogle Scholar
  28. Ramwell PW, Shaw JE, Jessup R (1966) Spontaneous and evoked release of prostaglandins from frog spinal cord. Am J Physiol 211: 998–1104PubMedGoogle Scholar
  29. Rosenkranz RP (1978) Effects of intracerebroventricular administration of PGE1? E2 and F2α on electrically induced convulsions in mice. Prostaglandins 15: 925–942PubMedCrossRefGoogle Scholar
  30. Rosenkranz RP, Killam KF (1978) Effects of prostacyclin and 6-keto PGF1α on electrically induced convulsions in mice. Life Sci 23: 2609–2616PubMedCrossRefGoogle Scholar
  31. Rosenkranz RP, Killam KF (1979) Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice. J Pharmacol Exp Ther 209: 231–237PubMedGoogle Scholar
  32. Rosenkranz RP, Killam KF (1981) Anticonvulsant effects of PGE2 on electrical, chemical and photomyoclonic animal models in epilepsy. Progr Lipid Res 20: 515–522CrossRefGoogle Scholar
  33. Samuelsson B (1964) Identification of a smooth muscle-stimulating factor in bovine brain. Biochim Biophys Acta 84: 218–219PubMedGoogle Scholar
  34. Van Dorp DA (1966) The biosynthesis of prostaglandins. Mem Soc Endocrinol 14: 39–47Google Scholar
  35. Van Woert MH, Hwang EC (1981) Role of brain serotonin in myoclonus. In: Morselli PL, Lloyd KG, Loscher W, Meldrum B, Reynolds EH (eds) Neurotransmitters, seizures, and epilepsy. Raven, New York, pp 239–247Google Scholar
  36. Wallenstein MC, Biko LZ (1977) Prostaglandin -induced alterations in visually-evoked response and production of epileptiform activity. Neuropharmacology 16: 687–694PubMedCrossRefGoogle Scholar
  37. Wolfe LS, Coceani F, Pace-Asciak C (1967) Brain prostaglandins and studies of the action of prostaglandins on the isolated rat stomach. In: Bergstrom S, Samuelsson B (eds) Nobel Symposium 2 on Prostaglandins. Almqvist and Wiksell, Stockholm, pp 265–275Google Scholar
  38. Wolfe LS, Rostworowski K, Pappius HM (1976 a) The endogenous biosynthesis of prostaglandins by brain tissue in vitro. Can J Biochem 54: 629–640Google Scholar
  39. Wolfe LS, Pappius HM, Marion J (1976 b) The biosynthesis of prostaglandins by brain tissue in vitro. Adv Prostaglandin Thromboxane Res 1: 345–365Google Scholar
  40. Wolfe LS, Rostworowski K, Marion J (1976 c) Endogenous formation of prostaglandin en-doperoxide metabolite thromboxane B2 by brain tissue. Biochem Biophys Res Comm 70: 907–913Google Scholar
  41. Yamamoto YL, Feindel W, Wolfe LS, Katch H, Hedge GP (1972) Experimental vasocon-striction on cerebral arteries by prostaglandins. Neurosurgery 37: 385–397CrossRefGoogle Scholar
  42. Zatz M, Roth RH (1975) Electroconvulsive shock raises prostaglandins F in rat cerebral cortex. Biochem Pharmacol 24: 2101–2103PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • K. Wiśniewski
  • H.-H. Frey

There are no affiliations available

Personalised recommendations