Abstract
Prostaglandin (PG) F2α in ox brain was the first PG to be discovered (SAmuelsson 1964). The occurrence of PGs in the brain of man and different animal species was confirmed in the following years by several groups (Bergstrom and Samuelsson 1965; Horton and Main 1967; Wolfe et al. 1967; Kataoka et al. 1967; Holmes and Norton 1968a,b; Wolfe et al. 1976c): PGE1 PGE2, PGF1α, PGF2α, and thromboxane B2 were all identified.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bergström S, Samuelsson B (1965) Prostaglandins. Ann Rev Biochem 34: 101–108
Bhattacharya SK, Sanyal AK (1978) Inhibition of pentylenetetrazole-induced convulsions in rats by prostaglandin E1 role of brain monoamines. Psychopharmacology 56: 235–237
Bradley PB, Samuels GMR, Shaw JE (1969) Correlation of prostaglandin release from the cerebral cortex of cats with electro-corticogram following stimulation of the reticular formation. Br J Pharmacol 37: 151–157
Climax J, Sewell RDE (1981) Modification of convulsive behaviour and body temperature in mice by intracerebroventricular administration of prostaglandins, arachidonic acid and the soluble acetylsalicylic acid salt lysine acetylsalicylate. Arch Int Pharmacodyn Ther 250: 254–265
Coceani F, Wolfe LS (1965) Prostaglandins in brain and the release of prostaglandin-like compounds from the cat cerebellar cortex. Can J Physiol Pharmacol 43: 445–450
Coceani F, Puglisi L, Lavers B (1971) Prostaglandins and neuronal activity in spinal cord and cuneate nucleus. Ann NY Acad Sci 180: 289–301
Duru S, Tiirker RK (1969) Effect of prostaglandin E1 on the strychnine-induced convulsion in the mouse. Experientia 25: 275–277
Förstermann V, Heldt R, Knappen E, Hertting G (1982) Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain. Brain Res 240: 303–310
Folco GC, Longiave D, Bosisio E (1977) Relations between prostaglandin E2, F2α and cyclic nucleotides. Levels in rat brain and induction of convulsions. Prostaglandins 13: 893–900
Galli C, Spagnuolo C, Petroni A (1980) Factors affecting brain prostaglandin formation. Adv Prostaglandin Thromboxane Res 8: 1235–1239
Hedqvist P (1973) Autonomic neurotransmission. In: Ramwell PW (ed) The prostaglandins, vol 1. Plenum, New York, pp 101–131
Hinman JW (1972) Prostaglandins. Ann Rev Biochem 41: 161–178
Holmes SW (1970) The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release. Br J Pharmacol 37: 635–658
Holmes SW, Horton EW (1968 a) The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system. J Physiol (Lond) 195: 731–741
Holmes SW, Horton EW ( 1968 b) Prostaglandins and the central nervous system. In: Ramwell PW, Shaw JE (eds) Worcester symposium on prostaglandins. Wiley, New York, pp 21–36
Horton EW (1969) Hypothesis on physiological roles of prostaglandins. Physiol Rev 49: 152–161
Horton EW (1972) Prostaglandins. Monographs on endocrinology, vol 7. Springer, Berlin Heidelberg New York, pp 117–149
Horton EW, Main JHM (1967) Identification of prostaglandins in central nervous tissues of the cat and chicken. Br J Pharmacol 30: 582–602
Kataoka K, Ramwell PW, Jessup S (1967) Prostaglandins: localization in subcellular particles or rat cerebral cortex. Science 157: 1187–1189
Kroner EE, Peskar BA (1976) On the metabolism of prostaglandins by rat brain homogenate. Experientia 32: 1114–1115
Lyneham RC, Low PA, McLeod JG, Shearman RP, Smith ID, Korda AR (1973) Convulsions and electroencephalogram abnormalities after intraamniotic prostaglandin F2α. Lancet II: 1003–1005
Pace-Asciak CR, Rangaraj G (1976 a) Prostaglandin biosynthesis and catabolism in the developing fetal sheep brain. J Biol Chem 251: 3381–3385
Pace-Asciak CR, Rangaraj G (1976 b) Distribution of prostaglandin biosynthetic pathways in organs and tissues of fetal lamb. Biochim Biophys Acta 528: 512–514
Poddubiuk ZM (1976) A comparison of the central actions of prostaglandins A1? E1 E2, F10α and F2α in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat. Psychopharmacology 50: 89–94
Poddubiuk ZM, Kleinrok Z (1976) A comparison of the central actions of prostaglandins A1? E1? E2, F1α and F2α in the rat. Psychopharmacology 50: 95–102
Potts WJ, East PF, Mueller RA (1974) Behavioral effects. In: Ramwell P (ed) Prostaglandins, vol 2. Plenum, New York, pp 157–173
Ramwell PW, Shaw JE (1966) Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats. Am J Physiol 211: 125–134
Ramwell PW, Shaw JE, Jessup R (1966) Spontaneous and evoked release of prostaglandins from frog spinal cord. Am J Physiol 211: 998–1104
Rosenkranz RP (1978) Effects of intracerebroventricular administration of PGE1? E2 and F2α on electrically induced convulsions in mice. Prostaglandins 15: 925–942
Rosenkranz RP, Killam KF (1978) Effects of prostacyclin and 6-keto PGF1α on electrically induced convulsions in mice. Life Sci 23: 2609–2616
Rosenkranz RP, Killam KF (1979) Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice. J Pharmacol Exp Ther 209: 231–237
Rosenkranz RP, Killam KF (1981) Anticonvulsant effects of PGE2 on electrical, chemical and photomyoclonic animal models in epilepsy. Progr Lipid Res 20: 515–522
Samuelsson B (1964) Identification of a smooth muscle-stimulating factor in bovine brain. Biochim Biophys Acta 84: 218–219
Van Dorp DA (1966) The biosynthesis of prostaglandins. Mem Soc Endocrinol 14: 39–47
Van Woert MH, Hwang EC (1981) Role of brain serotonin in myoclonus. In: Morselli PL, Lloyd KG, Loscher W, Meldrum B, Reynolds EH (eds) Neurotransmitters, seizures, and epilepsy. Raven, New York, pp 239–247
Wallenstein MC, Biko LZ (1977) Prostaglandin -induced alterations in visually-evoked response and production of epileptiform activity. Neuropharmacology 16: 687–694
Wolfe LS, Coceani F, Pace-Asciak C (1967) Brain prostaglandins and studies of the action of prostaglandins on the isolated rat stomach. In: Bergstrom S, Samuelsson B (eds) Nobel Symposium 2 on Prostaglandins. Almqvist and Wiksell, Stockholm, pp 265–275
Wolfe LS, Rostworowski K, Pappius HM (1976 a) The endogenous biosynthesis of prostaglandins by brain tissue in vitro. Can J Biochem 54: 629–640
Wolfe LS, Pappius HM, Marion J (1976 b) The biosynthesis of prostaglandins by brain tissue in vitro. Adv Prostaglandin Thromboxane Res 1: 345–365
Wolfe LS, Rostworowski K, Marion J (1976 c) Endogenous formation of prostaglandin en-doperoxide metabolite thromboxane B2 by brain tissue. Biochem Biophys Res Comm 70: 907–913
Yamamoto YL, Feindel W, Wolfe LS, Katch H, Hedge GP (1972) Experimental vasocon-striction on cerebral arteries by prostaglandins. Neurosurgery 37: 385–397
Zatz M, Roth RH (1975) Electroconvulsive shock raises prostaglandins F in rat cerebral cortex. Biochem Pharmacol 24: 2101–2103
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wiśniewski, K., Frey, HH. (1985). Prostaglandins. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-69518-6_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69520-9
Online ISBN: 978-3-642-69518-6
eBook Packages: Springer Book Archive