Skip to main content
SpringerLink
Log in
Book cover

Antiepileptic Drugs pp 831–855Cite as

Antiepileptic Drug Interactions

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Antiepileptic drug interactions may be either pharmacokinetic or pharmacodynamic; this chapter discusses only the former. Due to the difficulties of extrapolating animal data to the clinical situation, this review will be restricted to studies which have been performed in normal human volunteers or in patients. Reference to animal experiments, however, will be made occasionally when these are considered to be particularly relevant to the interpretation of clinical findings.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abernethy D R, Greenblatt D J, Divoll M, Arendt R, Ochs H R, Shader R I (1982) Impairment of diazepam metabolism by low-dose estrogen-containing oral contraceptive steroids. N Engl J Med 306: 791–792

    Article  PubMed  CAS  Google Scholar 

  • Acocella G, Bonollo L, Mainardi M, Margardoli P (1974) Kinetic studies on rifampicin. III. Effect of phenobarbital on the half-life of the antibiotic. Tijdschr Gastroenterol 17: 151–158

    Google Scholar 

  • Ahmad S (1974) Renal insensitivity to frusemide caused by chronic anticonvulsant therapy. Br Med J 3: 657–659

    Article  PubMed  CAS  Google Scholar 

  • Ahmad S, Clarke L, Hewett AJ, Richens A (1976) Controlled trial of frusemide as an antiepileptic drug in focal epilepsy. Clin Pharmacokinet 3: 621–625

    Google Scholar 

  • Aitio M L, Vuorenmaa T (1980) Enhanced metabolism and diminished efficacy of diso-pyramide by enzyme-induction. Br J Clin Pharmacol 9: 149–152

    PubMed  CAS  Google Scholar 

  • Aitio M L, Mansbury L, Tala E, Haataja M, Aitio A (1981) The effect of enzyme induction on the metabolism of disopyramide in man. Br J Clin Pharmacol 11: 279–286

    PubMed  CAS  Google Scholar 

  • Alexanderson B, Price-Evans D A, Sjoqvist F (1969) Steady-state levels of nortriptyline in twins: influence of genetic factors and drug therapy. Br Med J 4: 764–768

    Article  PubMed  CAS  Google Scholar 

  • Alvan G, Piafsky K, Lind N, Von Bahr C (1977) Effect of pentobarbital on the disposition of alprenolol. Clin Pharmacol Ther 22: 316–321

    PubMed  CAS  Google Scholar 

  • Andreasen P B, Froland A, Skovsted L, Andersen S A, Hauge M (1973) Diphenylhydantoin half-life in man and its inhibition by phenylbutazone: the role of genetic factors. Acta Med Scand 193: 561–564

    Article  PubMed  CAS  Google Scholar 

  • Back D J, Breckenridge A M, Crawford F E, Maclver O, Orme Ml’E, Perucca E, Richens A, Rowe P H, Smith E (1980) The effect of oral contraceptive steroids and enzyme-inducing drugs on sex hormone binding globulin capacity in women. Br J Clin Pharmacol 9: 115 P

    Google Scholar 

  • Back D J, Bates M, Breckenridge A M, Ellis A, Hall J M, Maclver M, Orme Ml’E, Rowe P H (1981 a) The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa. Br J Clin Pharmacol 11: 275–278

    Google Scholar 

  • Back D J, Bates M, Bowden A, Breckenridge A M, Hall M J, Jones H, Maclver M, Orme Ml’E, Perucca E, Richens A, Rowe P H, Smith E (1981 b) The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. Contraception 22: 495–503

    Google Scholar 

  • Ballek R E, Reidenberg M M, Orr L (1973) Inhibition of diphenylhydantoin metabolism by chloramphenicol. Lancet 1:150 Ballinger B R, Prealy A, Reid A H, Stevenson I H (1974) The effects of hypnotics on imipramine treatment. Psychopharmacology 39: 267–274

    Google Scholar 

  • Barragry J M, Makin H L J, Trafford D J H, Scott D F (1978) Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels. J Neurol Neurosurg Psychiatry 41: 913–914

    Article  PubMed  CAS  Google Scholar 

  • Bauer L A (1982) Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology 32: 570–572

    PubMed  CAS  Google Scholar 

  • Baylis E M, Croley J M, Preece J M, Sylvester P E, Marks V (1971) Influence of folic acid on blood phenytoin levels. Lancet 1: 62–64

    Article  PubMed  CAS  Google Scholar 

  • Begg E J, Chinwah P M, Webb C, Day R O, Wade D N (1982) Enhanced metabolism of mexiletine after phenytoin administration. Br J Clin Pharmacol 14: 219–223

    PubMed  CAS  Google Scholar 

  • Bielmann I, Luac T, Gagnon M A (1978) Clonazepam: its efficacy in association with phenytoin and phenobarbital in mental patients in generalized major motor seizures. Int J Clin Pharmacol 16: 268–273

    CAS  Google Scholar 

  • Block S H (1982) Carbamazepine-isoniazid interaction. Pediatrics 69: 494–495

    PubMed  CAS  Google Scholar 

  • Bloxham R A, Durbin G M, Johnson T, Winterborn M H (1979) Chloramphenicol and phenobarbitone - a drug interaction. Arch Dis Child 54: 76

    Article  PubMed  CAS  Google Scholar 

  • Bochner F, Hooper W D, Tyrer J H, Eadie M J (1972) Factors involved in an outbreak of phenytoin intoxication. J Neurol Scand 16: 481–487

    Article  CAS  Google Scholar 

  • Bogaert M G, Rosseel M T, Belpaine F M (1971) Metabolism of nitroglycerine in man: influence of phenobarbital. Arch Int Pharmacodyn Ther 24: 1303–1311

    Google Scholar 

  • Bollini P, Riva R, Albani F, Ida N, Cacciari L, Bollini C, Baruzzi A (1983) Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia 24: 75–78

    Article  PubMed  CAS  Google Scholar 

  • Borga O, Azarnoff D L, Forshell G P, Sjoqvist F (1969) Plasma protein binding of tricyclic antidepressants in man. Biochem Pharmacol 18: 2135–2143

    Article  PubMed  CAS  Google Scholar 

  • Bourgeois B F D, Dodson W E, Ferrendelli J A (1982) Interactions between primidone, carbamazepine and nicotinamide. Neurology 32: 1122–1126

    PubMed  CAS  Google Scholar 

  • Bowdle T A, Levy R H, Cutler R E (1979) Effect of carbamazepine on valproic acid kinetics in normal subjects. Clin Pharmacol Ther 26: 629–634

    PubMed  CAS  Google Scholar 

  • Boylan J J, Owen D S, Chin J B (1976) Phenytoin interference with dexamethasone. JAMA 235: 803–804

    Article  PubMed  CAS  Google Scholar 

  • Braithwaite R A, Flanagan R A, Richens A (1975) Steady-state plasma nortriptyline concentrations in epileptic patients. Br J Clin Pharmacol 2: 469–471

    PubMed  CAS  Google Scholar 

  • Brennan R W, Dehejia H, Kutt H, Verebely K, McDowell F (1970) Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid. Neurology 20: 687–693

    PubMed  CAS  Google Scholar 

  • Brooks S M, Werk E E, Ackerman S J, Sullivan I, Thrasher K (1972) Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma. N Engl J Med 286: 1125–1128

    Article  PubMed  CAS  Google Scholar 

  • Brooks P M, Buchanan W W, Grove M, Downie N W (1976) Effects of enzyme-induction on metabolism of prednisolone. Clinical and laboratory study. Ann Rheum Dis 35: 339–343

    Google Scholar 

  • Brown J E, Kitchell B B, Bjornsson T D, Shand D G (1981) The artifactual nature of heparin-induced drug binding alteration. Clin Pharmacol Ther 30: 636–643

    Article  PubMed  CAS  Google Scholar 

  • Bruni J, Gallo J M, Lee C S, Perchalski R J, Wilder B J (1980 a) Interactions of valproic acid with phenytoin. Neurology 30: 1233–1236

    Google Scholar 

  • Bruni J, Wilder B J, Perchalski R J, Hammond E J, Villareal H J (1980 b) Valproic acid and plasma levels of phenobarbital. Neurology 30: 94–97

    Google Scholar 

  • Busfield D, Child K J, Atkinson R M, Tomich E G (1963) An effect of phenobarbitone on blood levels of griseofulvin in man. Lancet II: 1042

    Google Scholar 

  • Chapron D J, Kramer P A, Mariano S L, Hohnadel D C (1979 a) Effect of calcium and antacids on phenytoin bioavailability. Arch Neurol 36: 436–438

    Google Scholar 

  • Chapron D J, Numford D, Pitegoff G I ( 1979 b) Apparent quinidine-induced digoxin toxicity after withdrawal of pentobarbital. Case of sequential drug interactions. Arch Intern Med 139: 363–364

    Google Scholar 

  • Christensen L K, Skovsted L (1969) Inhibition of drug metabolism by chloramphenicol. Lancet II: 1397–1399

    Google Scholar 

  • Cloyd J C, Miller K W, Leppik I E (1981) Primidone kinetics: effects of concurrent drugs and duration of therapy. Clin Pharmacol Ther 29: 402–407

    Article  PubMed  CAS  Google Scholar 

  • Collste P, Seideman P, Borg K O, Haglund K, Von Bahr C (1979) Influence of pentobarbital on effect and plasma levels of alprenolol and 4-hydroxy-alprenolol. Clin Pharmacol Ther 25: 423–127

    PubMed  CAS  Google Scholar 

  • Coulam C B, Annegers J F (1979) Do anticonvulsants reduce the efficacy of oral contraceptives? Epilepsia 20: 519–526

    Article  PubMed  CAS  Google Scholar 

  • Cramer J A, Mattson R H (1979) Valproic acid: in vitro plasma protein binding and interaction with phenytoin. Ther Drug Monit 1: 105–116

    Article  PubMed  CAS  Google Scholar 

  • Cunningham J L, Price-Evans D A (1981) Acetanilide and paracetamol pharmacokinetics before and after phenytoin administration: genetic control of induction. Br J Clin Pharmacol 11: 591–596

    PubMed  CAS  Google Scholar 

  • Dahlqvist R, Borgå O, Rane A, Walsh Z, Sjoqvist F (1979) Decreased plasma protein binding of phenytoin in patients on valproic acid. Br J Clin Pharmacol 8: 547–552

    PubMed  CAS  Google Scholar 

  • Dam M, Jensen A, Christiansen J (1975) Plasma level and effect of carbamazepine in grand

    Google Scholar 

  • mal and psychomotor epilepsy. Acta Neurol Scand [Suppl] 60:33–38

    Google Scholar 

  • Dam M, Kristensen C B, Hansen B S, Christiansen J (1977) Interaction between carbamazepine and propoxyphene in man. Acta Neurol Scand 56: 603–607

    Article  PubMed  CAS  Google Scholar 

  • Dana-Haeri J, Richens A (1981) Effect of antiepileptic drugs on the hypothalamic pituitary axis. Br Med J 282: 902

    Article  CAS  Google Scholar 

  • Data J L, Wilkinson G R, Nies A S (1976) Interaction of quinidine with anticonvulsant drugs. N Engl J Med 294: 699–702

    Article  PubMed  CAS  Google Scholar 

  • De Rautlin de La Roy Y, Beauchant G, Breuil K, Patte F (1971) Diminution du taux sérique de rifampicine par le phenobarbital. Presse Med 79: 350

    Google Scholar 

  • Desmond P V, Roberts R K, Wilkinson G R, Wood A J J, Dunn D, Schenker S (1979) The effect of heparin on benzodiazepine binding. Fed Proc 38: 743

    Google Scholar 

  • Dhillon S, Richens A (1981 a) Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. Br J Clin Pharmacol 12: 841–844

    Google Scholar 

  • Dhillon S, Richens A (1981 b) Serum protein binding of diazepam and its displacement by valproic acid in vitro. Br J Clin Pharmacol 12: 591–592

    Google Scholar 

  • Dhillon S, Richens A (1982) Valproic acid and diazepam interaction in vivo. Br J Clin Pharmacol 13: 553–560

    PubMed  CAS  Google Scholar 

  • Dravet C, Mesdjan E, Cenraud B, Roger J (1977) Interaction between carbamazepine and triacetyloleandomycin. Lancet 1: 810–811

    Article  PubMed  CAS  Google Scholar 

  • Editorial (1980) Drug interactions with oral contraceptive steroids. Br Med J 281: 93–94

    Article  Google Scholar 

  • Eichelbaum M, Kothe K W, Hoffmann F, Von Unruh G E (1979) Kinetics and metabolism of carbamazepine during combined antiepileptic therapy. Clin Pharmacol Ther 26: 367–371

    Google Scholar 

  • Fincham R W, Schottelius D D (1979) Decreased phenytoin levels in antineoplastic therapy. Ther Drug Monit 1: 277–283

    Article  PubMed  CAS  Google Scholar 

  • Fincham R W, Schottelius D D, Sahs AL (1974) The influence of diphenylhydantoin on primidone metabolism. Arch Neurol 30: 259–262

    PubMed  CAS  Google Scholar 

  • Fincham R W, Wiley D E, Schottelius D D (1976) Use of phenytoin serum levels in a case of status epilepticus. Neurology 26: 879–881

    PubMed  CAS  Google Scholar 

  • Fine A, Henderson I S, Morgan D R, Tilstone W J (1977) Malabsorption of frusemide caused by phenytoin. Br Med J 2: 1061–1062

    Article  PubMed  CAS  Google Scholar 

  • Finelli PF (1976) Phenytoin and methadone tolerance. N Engl Med 294: 110

    Google Scholar 

  • Flachs H, Gram L, Wiirtz-Jorgensen A, Parnas J (1979) Drug levels of other antiepileptic drugs during concomitant treatment with sodium valproate. Epilepsia 20: 187

    Google Scholar 

  • Fleitman J S, Bruni J, Perrin J H, Wilder B J (1980) Albumin-binding interactions of sodium valproate. J Clin Pharmacol 20: 514–517

    PubMed  CAS  Google Scholar 

  • Frantzen E, Hansen J M, Hansen O E, Kristensen M (1967) Phenytoin (Dilantin®) intoxication. Acta Neurol Scand 43: 440–446

    Article  PubMed  CAS  Google Scholar 

  • Fraser D G, Ludden T M, Evens R P, Sutherland E W III (1980): Displacement of phenytoin from plasma binding sites by salicylate. Clin Pharmacol Ther 27: 165–169

    Article  PubMed  CAS  Google Scholar 

  • Friel P N, Leal K W, Wilensky A J (1979) Valproic acid-phenytoin interaction. Ther Drug Monit 1: 243–248

    Article  PubMed  CAS  Google Scholar 

  • Frigo G M, Lecchini S, Caravaggi M, Gatti G, Tonini M, D’Angelo L, Perucca E, Crema A (1983) Reduction in phenytoin clearance caused by cimetidine. Eur J Clin Pharmacol 25: 135–137

    Article  PubMed  CAS  Google Scholar 

  • Fuji K, Hayashi M, Murata R (1975) Effect of diphenylhydantoin therapy on plasma 11-OHCS: interference in the effects of dexamethasone and metapirone. Brain Dev 7: 354–360

    Google Scholar 

  • Furlanut M, Rizzoni G (1980) Effetti del dipropilacetato sulla cinetica della antipirina (Abstr). Proceedings 20th Meeting of the Italian Pharmacological Society ( SIF ), Verona

    Google Scholar 

  • Furlanut M, Benetello P, Avogaro A, Dainese R (1978) Effects of folic acid on phenytoin kinetics in healthy subjects. Clin Pharmacol Ther 24: 294–297

    PubMed  CAS  Google Scholar 

  • Gangji D, Schwade JG, Strong J M (1980) Phenytoin-misonidazole: a possible metabolic interaction. Cancer Treat Rep 64: 155–156

    PubMed  CAS  Google Scholar 

  • Garratt W R, Carter B L, Pellock JM (1979) Bioavailability of phenytoin administered with antacids. Ther Drug Monit 1: 435–437

    Article  Google Scholar 

  • Garrettson L K, Perel J M, Dayton P G (1969) Methylphenidate interaction with both anticonvulsants and ethyl-biscoumacetate. JAMA 207: 2053–2056

    Article  PubMed  CAS  Google Scholar 

  • Geaney D P, Carver J G, Davies C L, Aronson J K (1983) Pharmacokinetic investigation of the interaction of azapropazone with phenytoin. Brit J Clin Pharmacol 15: 727–734

    CAS  Google Scholar 

  • Giacomini K, Giacomini J, Blaschke T (1980) Heparin decreases plasma protein binding of drugs. Clin Pharmacol Ther 27: 256

    Article  Google Scholar 

  • Goldberg MJ, Berlinger WG (1982) Treatment of phenobarbital overdose with activated charcoal. JAMA 247: 2400–2401

    Article  PubMed  CAS  Google Scholar 

  • Greenblatt D J, Shader R I, Harmatz J S, Franke K, Koch-Weser J (1976) Influences of magnesium and aluminium hydroxide mixture on chlordiazepoxide absorption. Clin Pharmacol Ther 19: 234–239

    PubMed  CAS  Google Scholar 

  • Gugler R, Von Unrhuh G E (1980) Clinical pharmacokinetics of valproic acid. Clin Pharmacokinet 5: 67–83

    Article  PubMed  CAS  Google Scholar 

  • Gupta S (1982) Phenobarbital and metabolism of metronidazole. N Engl J Med 308: 529

    Google Scholar 

  • Haglund K, Seideman P, Collste B, Borg K O, Von Bahr C (1979) Influence of pentobarbital on metroprolol plasma levels. Clin Pharmacol Ther 26: 326–329

    PubMed  CAS  Google Scholar 

  • Hahn T J (1976) Bone complications of anticonvulsants. Drugs 12: 210–211

    Article  Google Scholar 

  • Hammer W, Idestrom C M, Sjoqvist F (1967) Chemical control of antidepressant drug therapy. Minerva Med Int Congr Ser 122: 301–310

    Google Scholar 

  • Hancock K W, Levell M J (1978) Primidone/dexamethasone interaction. Lancet 11: 97–98

    Article  Google Scholar 

  • Hansen J M, Kristensen M, Skovsted L, Christensen L K (1966) Dicoumarol-induced diphenylhydantoin intoxication. Lancet 11: 265–266

    Article  Google Scholar 

  • Hansen JM, Kristensen M, Skovsted L (1968) Sulthiame (Ospolot®) as inhibitor of diphenylhydantoin metabolism. Epilepsia 9: 17–22

    Google Scholar 

  • Hansen J M, Siersbaek-Nielsen K, Kristensen M, Skovsted L, Christensen L K (1971 a) Effect of diphenylhydantoin on the metabolism of dicoumarol in man. Acta Med Scand 189: 15–19

    Google Scholar 

  • Hansen J M, Siersbaek-Nielsen K, Skovsted L (1971b) Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin Pharmacol Ther 12: 539–543

    PubMed  CAS  Google Scholar 

  • Hansen J M, Kampmann J P, Siersbaek-Nielsen K, Lumholtz I B, Arroe M, Abilgaard V, Skovsted L (1979) The effect of different sulfonamides on phenytoin metabolism in man. Acta Med Scand [Suppl] 624: 106–110

    CAS  Google Scholar 

  • Hansen B S, Dam M, Brandt J, Hvidberg E F, Angelo H, Christensen J M, Lous P (1980 a) Influence of dextropropoxyphene on steady-state serum levels and protein binding of three antiepileptic drugs. Acta Neurol Scand 61: 357–367

    Google Scholar 

  • Hansen J M, Busk G, Niemi G, Haase N J, Lumholtz B, Skovsted L, Kampmann JP ( 1980 b) Inhibition of phenytoin metabolism by sulfinpyrazone (Abstr 0584 ). In: Turner P, Padgham C (eds) Abstracts of the world conference on clinical pharmacology and therapeutics, London. MacMillan, London

    Google Scholar 

  • Hansten P D (1973) Drug interactions. Lea and Febiger, Philadelphia Hayes S L, Pablo G, Radomski T, Palmer R F (1977) Ethanol and oral diazepam absorption. N Engl J Med 296: 186–189

    Google Scholar 

  • Hedrick R, Williams F, Morin R, Lamb W A, Cate J C IV (1983) Carbamazepine-erythromycin interaction leading to carbamazepine toxicity in four epileptic children. Ther Drug Monit 5: 405–407

    Google Scholar 

  • Heijertz R, Pilz H (1978) Interaction of nitrofurantoin with diphenylhydantoin. J Neurol 218: 297–301

    Article  Google Scholar 

  • Hempel E, Klinger W (1976) Drug stimulated biotransformation of hormonal steroid contraceptives: clinical implications. Drugs 12: 442–448

    Article  PubMed  CAS  Google Scholar 

  • Hendeles L (1979) Decreased oral phenytoin absorption following concurrent theophylline administration. J Allergy Clin Immunol 63: 156

    Google Scholar 

  • Herishanu Y, Eylath U, Ilan R (1976) Effect of calcium content of diet on absorption of diphenylhydantoin. Israel J Med Sci 12: 1453–1456

    PubMed  CAS  Google Scholar 

  • Hetzel D J, Bochner F, Hallpike J F, Sherman D J C, Hann C S (1981) Cimetidine interaction with phenytoin. Br Med J 282: 1512

    Article  CAS  Google Scholar 

  • Hewick D S, Sparks R G, Stevenson I H, Watson I D (1977) Induction of imipramine metabolism following barbiturate administration. Br J Clin Pharmacol 4: 399

    Google Scholar 

  • Hooper W O, Sutherland J M, Bochner F, Tyrer J G, Eadie M J (1971) The effect of certain drugs on the plasma protein binding of diphenylhydantoin. Aust NZ J Med 3: 377–381

    Article  Google Scholar 

  • Houghton G W, Richens A (1974 a) Phenytoin intoxication induced by sulthiame in epileptic patients. J Neurol Psychiatry 37: 275–281

    Google Scholar 

  • Houghton G W, Richens A (1974 b) Inhibition of phenytoin metabolism by sulthiame in epileptic patients. Br J Clin Pharmacol 1: 59–66

    Google Scholar 

  • Huisman J W, van Heycop Ten Ham M W, van Zijl C H W (1970) Influence of ethyl-phenacemide on serum levels of other antiepileptic drugs. Epilepsia 11: 207–215

    CAS  Google Scholar 

  • Hurwitz A (1977) Antacid therapy and drug kinetics. Clin Pharmacol 2: 269–280

    Article  CAS  Google Scholar 

  • Jao J Y, Jusko W J, Cohen J L (1972) Phenobarbital effects on cyclophosphamide pharmacokinetics. Cancer Res 32: 2761–2764

    PubMed  CAS  Google Scholar 

  • Jelliffe R W, Blankenhorn D H (1966) Effect of phenobarbital on digitoxin metabolism. Clin Res 14: 160

    Google Scholar 

  • Johannessen S I, Strandjord R E, Munthe-Kaas A W (1977) Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine. Acta Neurol Scand 55: 506–512

    Article  PubMed  CAS  Google Scholar 

  • Jordan B J, Shillingford J S, Steed K P (1976) Preliminary observations on the protein binding and enzyme-inducing properties of sodium valproate (Epilim). In: Legg NJ (ed) Clinical and pharmacological aspects of sodium valproate (Epilim) in the treatment of epilepsy, MCS consultants, Tunbridge Wells, pp 112–116

    Google Scholar 

  • Jubiz W, Meikle A W (1979) Alterations of glucocorticoid actions by other drugs and disease states. Clin Pharmacokinet 18: 113–121

    CAS  Google Scholar 

  • Jubiz W, Meikle A W, Levinson R A, Mizutani S, West C D, Tyler F H (1970) Effect of diphenylhydantoin on the metabolism of dexamethasone. N Engl J Med 283: 11–14

    Article  PubMed  CAS  Google Scholar 

  • Kaldor A, Somogyi G, Debreczen L A (1975) Interaction of heart glycosides and pentobarbital. Int J Clin Pharmacol 12: 403

    CAS  Google Scholar 

  • Kapetenanovic I M, Kupferberg H J, Porter R J, Theodore W, Schulman E, Penry J K (1981) Mechanism of valproate-phenobarbital interaction in epileptic patients. Clin Pharmacol Ther 29: 480–486

    Article  Google Scholar 

  • Karch F E, Wardell W M, Dambly M, Gringeri A (1977) Effect of halofenate on the serum binding of phenytoin. Br J Clin Pharmacol 4: 625–626

    PubMed  CAS  Google Scholar 

  • Kater R M H, Roggin G, Tobon F, Zieve P, Iber F L (1969) Increased rate of clearance of drugs from the circulation of alcoholics. Am J Med Sci 258: 35–39

    Article  PubMed  CAS  Google Scholar 

  • Khoo K L, Mendels J, Rothbart M, Garland W A, Colburn W A, Min B H, Lucek R, Carbone J J, Boxenbaum H G, Kaplan S A (1980) Influence of phenytoin and phenobarbital on the disposition of a single oral dose of diazepam. Clin Pharmacol Ther 28: 368–375

    Article  PubMed  CAS  Google Scholar 

  • Klotz V, Reimann I (1980) Delayed clearance of diazepam due to cimetidine. N Engl J Med 302: 1012–1014

    Article  PubMed  CAS  Google Scholar 

  • Knott C, Hamshaw-Thomas A, Reynolds F (1982) Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. Br Med J 284: 13–16

    Article  CAS  Google Scholar 

  • Koch K M, Ludwick B T, Levy R H (1981) Phenytoin-valproic acid interaction in rhesus monkey. Epilepsia 22: 19–25

    Article  PubMed  CAS  Google Scholar 

  • Koch-Weser J, Sellers ES (1976) Binding of drugs to serum albumin. N Engl J Med 292: 311–316

    Article  Google Scholar 

  • Koranyi L, Gero L (1979) Influence of diphenylhydantoin on the effect of streptozotocin. Br Med J 1: 127

    Article  PubMed  CAS  Google Scholar 

  • Koup J R, Gibaldi M, McNamara P, Hilligoss D M, Colburn W A, Bruck E (1978) Interaction of chloramphenicol with phenytoin and phenobarbital. Clin Pharmacol Ther 24: 571–575

    PubMed  CAS  Google Scholar 

  • Kulshrestha V K, Thomas M, Wadsworth J, Richens A (1978) Interaction between phenytoin and antacids. Br J Clin Pharmacol 6: 177–179

    PubMed  CAS  Google Scholar 

  • Kurata D, Wilkinson G R (1974) Erythrocyte uptake and plasma binding of diphenylhydantoin. Clin Pharmacol Ther 16: 355–362

    PubMed  CAS  Google Scholar 

  • Kutt H (1971) Biochemical and genetical factors regulating Dilantin® metabolism in man. Ann NY Acad Sci 179: 704–722

    Article  CAS  Google Scholar 

  • Kutt H (1972) Diphenylhydantoin. Interactions with other drugs in man. In: Woodbury D M, Penry I K, Schmid R P (eds) Antiepileptic drugs. Raven, New York, pp 169–180

    Google Scholar 

  • Kutt H, Louis S (1972) Anticonvulsant drugs. II. Clinical pharmacological therapeutic aspects. CurrTher (Phila) 13: 58–82

    Google Scholar 

  • Kutt H, Winters W, McDowell F H (1966) Depression of parahydroxylation of diphenylhydantoin by antituberculosis chemotherapy. Neurology 16: 594–602

    PubMed  CAS  Google Scholar 

  • Kutt H, Brennan R, Dehejia H, Verebely K (1970) Diphenylhydantoin intoxication. A complication of isoniazid therapy. Am Rev Respir Dis 101: 377–384

    Google Scholar 

  • Labadarios D, Dickerson J W T, Parke D V, Lucas E G, Obuwa G H (1978) The effects of chronic drug administration on hepatic enzyme-induction and folate metabolism. Br J Clin Pharmacol 5: 167–173

    PubMed  CAS  Google Scholar 

  • Lai A A, Levy R H, Cutler R E (1978) Time course of interaction between carbamazepine and clonazepam in normal man. Clin Pharmacol Ther 24: 316–323

    PubMed  CAS  Google Scholar 

  • Laizi V, Linnoila M, Seppala T, Himberg J J, Mattila M J (1979) Pharmacokinetic and pharmacodynamic interactions of diazepam with different alcoholic beverages. Eur J Clin Pharmacol 16: 262–270

    Google Scholar 

  • Lambie D G, Johnson R (1981) The effects of phenytoin on phenobarbitone and primidone metabolism. J Neurol Neurosurg Psychiatry 44: 148–151

    Article  PubMed  CAS  Google Scholar 

  • Landay R A, Gonzalez M A, Taylor J C (1978) Effect of phenobarbital on theophylline disposition. J Allergy Clin Immunol 62: 27–29

    Article  PubMed  CAS  Google Scholar 

  • Leonard R F, Knott P J, Rankin G O, Robinson D S, Melnick D E (1981) Phenytoin-salicy-late interaction. Clin Pharmacol Ther 29: 56–60

    Article  PubMed  CAS  Google Scholar 

  • Lewis R (1966) Effect of barbiturates on anticoagulant therapy. N Engl J Med 274: 110

    Google Scholar 

  • Linnoila M, Viukari M, Vaisanen K, Auvinen J (1980) Effect of anticonvulsants on plasma haloperidol and thioridazine levels. Am J Psych 137: 819–821

    CAS  Google Scholar 

  • Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM (1975) Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism. Clin Pharmacol Ther 17: 731–734

    PubMed  CAS  Google Scholar 

  • Lunde P K M, Rane A, Yaffe S J, Lund L, Sjoqvist F (1970) Plasma protein bindings of diphenylhydantoin in man. Clin Pharmacol Ther 11: 846–855

    PubMed  CAS  Google Scholar 

  • MacDonald M G, Robinson D S (1968) Clinical observations of possible barbiturate interference with anticoagulation. JAMA 204: 97–99

    Article  PubMed  CAS  Google Scholar 

  • MacLeod S M, Sellers E M, Giles H G, Billings B J, Martin P R, Greenblatt D J, Marshman J A (1978) Interaction of disulfiram with benzodiazepines. Clin Pharmacol Ther 24: 583–589

    PubMed  CAS  Google Scholar 

  • Makki K A, Perucca E, Richens A (1980) Metabolic effects of folic acid replacement therapy in folate-deficient epileptic patients. In: Johannessen S I, Morselli P L, Pippenger C E; Richens A, Schmidt D, Meinardi H (eds) Antiepileptic therapy. Advances in drug monitoring. Raven, New York, pp 391–396

    Google Scholar 

  • Marquis J F, Carruthers S G, Spence J D, Brownstone Y S, Toogood J H (1982) Phenytoin-theophylline interaction. N Engl J Med 307: 1189–1190

    Article  PubMed  CAS  Google Scholar 

  • Mattson R H, Gallagher B B, Reynolds E H, Glass D (1973) Folate therapy in epilepsy. A controlled study. Arch Neurol 29: 78–81

    Google Scholar 

  • Mattson R H, Cramer J A, Williamson P C, Novelly R A (1978) Valproic acid in epilepsy: clinical and pharmacological effects. Ann Neurol 3: 20–25

    Article  PubMed  CAS  Google Scholar 

  • Mattson G F, Mattson R H, Cramer J A (1982) Interaction between valproic acid and carbamazepine: an in vitro study of protein binding. Ther Drug Monit 4: 181–184

    Article  PubMed  CAS  Google Scholar 

  • McLelland J, Jack W (1978) Phenytoin/dexamethasone interactions: a clinical problem. Lancet 1: 1096–1097

    Article  PubMed  CAS  Google Scholar 

  • Mead P B, Gibson M, Schentag J J, Ziemniak J A (1982) Possible alteration of metronidazole metabolism by phenobarbital. N Engl J Med 306: 1490

    PubMed  CAS  Google Scholar 

  • Meikle A W, Jubiz W, Matsukura S, West C D, Tyler F H (1969) Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man. J clin Endocrinol Metab 29: 1553–1558

    Article  PubMed  CAS  Google Scholar 

  • Mellett L B (1971) Chemistry and metabolism of cyclophosphamide. In: Vancil (ed) Immunosuppressive properties of cyclophosphamide. Mead and Johnson, Evansville, pp 6–34

    Google Scholar 

  • Mihaly G W, Vajda F J, Miles J L, Louis W J (1979) Single and chronic dose pharmacokinetic studies of sodium valproate in epileptic patients. Eur J Clin Pharmacol 16: 23–29

    Article  PubMed  CAS  Google Scholar 

  • Miller R R, Porter J, Greenblatt D J (1979) Clinical importance of the interaction of phenytoin and isoniazid. A report from the Boston collaborative drug surveillance program. Chest 75: 356–358

    Google Scholar 

  • Monks A, Richens A (1980) Effect of a single dose of sodium valproate on serum phenytoin concentration and protein binding in epileptic patients. Clin Pharmacol Ther 27: 89–95

    Article  PubMed  CAS  Google Scholar 

  • Monks A, Boobis S, Wadsworth J, Richens A (1978) Plasma protein binding interaction between phenytoin and valproic acid in vitro. Br J Clin Pharmacol 6: 487–492

    PubMed  CAS  Google Scholar 

  • Moody J P, Whyte S F, McDonald A J, Naylor G J (1977) Pharmacokinetic aspects of pro-triptyline plasma levels. Eur J Clin Pharmacol 11: 51–56

    Article  PubMed  CAS  Google Scholar 

  • Morselli P, Rizzo M, Garattini S (1971) Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients. Ann NY Acad Sci 179: 88–107

    Article  PubMed  CAS  Google Scholar 

  • Murray F J (1962) Outbreak of unexpected reactions among epileptics taking isoniazid. Am Rev Respir Dis 86: 729–732

    PubMed  CAS  Google Scholar 

  • Nanda R N, Johnson R H, Keogh H J, Lambie D G, Melville I D (1977) Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. J Neurol Neurosurg Psychiatry 40: 538–543

    Article  PubMed  CAS  Google Scholar 

  • Nappi J (1979) Warfarin and phenytoin interaction. Ann Intern Med 90: 852

    PubMed  CAS  Google Scholar 

  • Nawishi S, Hathaway N (1982) Nomifensine pharmacokinetics in patients with epilepsy. Br J Clin Pharmacol 13: 295

    Google Scholar 

  • Nawishi S, Hathaway N, Turner P (1981) Interactions of anticonvulsant drugs with mianserin and nomifensine. Lancet 11: 870–871

    Google Scholar 

  • Neuvonen P J, Elonen E (1980) Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man. Eur J Clin Pharmacol 15: 51–57

    Article  Google Scholar 

  • Neuvonen PJ, Penttila O (1974) Interaction between doxycycline and barbiturates. Br Med J 1: 535–536

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen P J, Elfving S M, Elonen E (1978) Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man. Eur J Clin Pharmacol 13: 213–218

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen P J, Lehtovaara R, Bardy A, Elonen E (1979) Antipyrine analgesics in patients on antiepileptic drug therapy. Eur J Clin Pharmacol 15: 263–268

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen P J, Kannisto H, Hirvisalo E L (1983) Effect of activated charcoal on absorption of tolbutamide and valproate in man. Eur J clin Pharmacol 24: 243–246

    Article  PubMed  CAS  Google Scholar 

  • Notelovitz M, Tjapkes J, Ware M (1981) Interaction between oestrogen and Dilantin in a menopausal woman. N Engl J Med 304: 788–789

    Article  PubMed  CAS  Google Scholar 

  • O’Brien LS, Orme Ml’E, Breckenridge AM (1978) Failure of antacids to alter the pharmacokinetics of phenytoin. Br J Clin Pharmacol 6: 176–177

    PubMed  Google Scholar 

  • Ochs H R, Greenblatt D J, Roberts G M, Dengler H J (1981) Interaction of diazepam with antituberculosis drugs. Clin Pharmacol Ther 29: 270

    Article  Google Scholar 

  • Odar-Cederlof I, Borga O (1976) Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid. Clin Pharmacol Ther 20: 36–47

    PubMed  CAS  Google Scholar 

  • Ohnhaus E E, Park B K, Colombo J P, Heizmann P (1979) The effect of enzyme-induction on diazepam metabolism in man. Br J Clin Pharmacol 8: 557–563

    PubMed  CAS  Google Scholar 

  • Olanow C W, Finn A L, Prussak C (1981) The effects of salicylate on the pharmacokinetics of phenytoin. Neurology 31: 341–342

    PubMed  CAS  Google Scholar 

  • Olesen O V (1967) The influence of disulfiram and calcium carbide on the serum diphenylhydantoin. Excretion of HPPH in the urine. Arch Neurol 16: 642–644

    PubMed  CAS  Google Scholar 

  • Olesen O V, Jensen O N (1969) Drug interaction between sulthiame (Ospolot®) and phenytoin in the treatment of epilepsy. Dan Med Bull 16: 154–158

    PubMed  CAS  Google Scholar 

  • Oppenheimer J H (1968) Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones. N Engl J Med 278: 1153

    Article  PubMed  CAS  Google Scholar 

  • Orr J M, Abbott F S, Farrell K, Ferguson S, Sheppard I, Godolphin W (1982) Interaction between valproic acid and aspirin in epileptic children: serum protein binding and metabolic effects. Clin Pharmacol Ther 31: 642–649

    Article  PubMed  CAS  Google Scholar 

  • Oxley J, Hedges A, Makki K A, Monks A, Richens A (1979) Lack of hepatic enzyme-inducing effect of sodium valproate. Br J Clin Pharmacol 8: 189–190

    PubMed  CAS  Google Scholar 

  • Patel J H, Levy R H, Cutler R E (1980) Phenobarbital-valproic acid interaction in normal man. Clin Pharmacol Ther 27: 515–521

    Article  PubMed  CAS  Google Scholar 

  • Patsalos P N, Lascelles P T (1977) Effect of sodium valproate on plasma protein binding of diphenylhydantoin. J Neurol Neurosurg Psychiatry 40: 570–574

    Article  PubMed  CAS  Google Scholar 

  • Paxton J W (1980) Effects of aspirin on salivary and serum phenytoin kinetics in healthy subjects. Clin Pharmacol Ther 27: 170–178

    Article  PubMed  CAS  Google Scholar 

  • Penttila O, Neuvonen P J, Aho K, Lehtovaara R (1974) Interaction between doxycycline and some antiepileptic drugs. Br Med J 2: 470–472

    Article  PubMed  CAS  Google Scholar 

  • Perucca E (1978) Clinical consequences of microsomal enzyme-induction by antiepileptic drugs. Pharmacol Ther 2: 285–314

    CAS  Google Scholar 

  • Perucca E (1982) Pharmacokinetic interactions with antiepileptic drugs. Clin Pharmacokinet 7: 57–84

    Article  PubMed  CAS  Google Scholar 

  • Perucca E, Richens A (1977) Interaction between phenytoin and imipramine. Br J Clin Pharmacol 4: 484–486

    Google Scholar 

  • Perucca E, Richens A (1979 a) Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs. Br J Clin Pharmacol 7: 201–206

    Google Scholar 

  • Perucca E, Richens A (1979 b) Reduction of the oral availability of lignocaine by induction of first-pass metabolism in epileptic patients. Br J Clin Pharmacol 8: 21–31

    Google Scholar 

  • Perucca E, Richens A (1980 a) Water intoxication produced by carbamazepine and its reversal by phenytoin. J Neurol Neurosurg Psychiatry 43: 540–545

    Google Scholar 

  • Perucca E, Richens A (1980 b) Interpretation of drug levels: Relevance of plasma protein

    Google Scholar 

  • binding. Ciba Found Symp 74:51–68

    Google Scholar 

  • Perucca E, Richens A ( 1980 c) Anticonvulsant drug interactions, In: Tyrer J (ed) The treatment of epilepsy. MTP, Lancaster, pp 95–128

    Google Scholar 

  • Perucca E, Richens A (1981) Drug interactions with phenytoin. Drugs 21: 120–137

    Article  PubMed  CAS  Google Scholar 

  • Perucca E, Gatti G, Frigo G M, Crema A, Calzetti S, Visintini D (1978) Disposition of sodium valproate in epileptic patients. Br J Clin Pharmacol 5: 495–499

    PubMed  CAS  Google Scholar 

  • Perucca E, Hedges A, Makki K, Hebdige S, Wadsworth J, Richens A (1979) The comparative enzyme-inducing properties of antiepileptic drugs. Br J Clin Pharmacol 7: 414–415 P

    Google Scholar 

  • Perucca E, Hebdige S, Gatti G, Lecchini S, Frigo GM, Crema A (1980) Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects. Clin Pharmacol Ther 28: 779–789

    Article  PubMed  CAS  Google Scholar 

  • Pfiasky K M, Sitar D S, Ogilvie R I (1977) Effect of phenobarbital on the disposition of intravenous theophylline. Clin Pharmacol Ther 22: 336–339

    Google Scholar 

  • Pisani F, Narbone MC, Fazio A, Crisafulli P, Primerano G, Amendola D’ Agostino A, Oteri G, DiPerri R (1984) Effect of viloxazine on serum carbamazepine levels in epileptic patients. Epilepsia 25: 482–485

    Google Scholar 

  • Pond S M, Kretzschmar K M (1981) Decreased bioavailability and increased clearance of meperidine during phenytoin administration. Clin Pharmacol Ther 29: 273

    Google Scholar 

  • Porter R J, Layzer R P (1975) Plasma albumin concentration and diphenylhydantoin binding in man. Arch Neurol 32: 298–303

    PubMed  CAS  Google Scholar 

  • Powell J R, Nelson E, Conrad K A, Likes K, Byers J III, Perrier D (1981) Phenobarbital clearance, elimination with alkaline diuresis and bioavailability in adults. Clin Pharmacol Ther 29: 273

    Google Scholar 

  • Prescott L F, Critchley JAJ, Balali-Mood M, Pentland B (1981) Effect of microsomal enzyme-induction on paracetamol metabolism in man. Br J Clin Pharmacol 12: 149–154

    PubMed  CAS  Google Scholar 

  • Pugh R N H, Geddes A M, Yeoman W B (1975) Interaction of phenytoin and chlorpheniramine. Br J Clin Pharmacol 2: 173–174

    PubMed  CAS  Google Scholar 

  • Rambeck B (1979) Pharmacological interactions of methsuximide with phenobarbital and phenytoin in hospitalized epileptic patients. Epilepsia 20: 147–156

    Article  PubMed  CAS  Google Scholar 

  • Rawlins MD, Collste P, Bertilsson L, Palmer L (1975) Distribution and elimination kinetics of carbamazepine in man. Eur J Clin Pharmacol 8: 91–96

    Article  PubMed  CAS  Google Scholar 

  • Reed R C, Schwartz H J (1982) Phenytoin-theophylline-quinidine interaction. N Engl J Med 308: 724–725

    Google Scholar 

  • Reilly M J (1973) Drug information digest: methotrexate USP (amethopterin) and methotrexate sodium. Am J Hosp Pharm 30: 543–548

    Google Scholar 

  • Reynolds E H, Fenton G, Fenwick P, Johnson Al, Laundy M (1975) Interaction of phenytoin and primidone. Br Med J 2: 594–595

    Article  PubMed  CAS  Google Scholar 

  • Richens A (1976) Drug treatment of epilepsy. Kimpton, London, pp 108–109

    Google Scholar 

  • Richens A, Houghton G W (1975) Effect of drug therapy on the metabolism of phenytoin. In: Schneider H, Janz D, Gardner-Thorpe C, Meinardi H, Sherwin AL (eds) Clinical pharmacology of antiepileptic drugs. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Riegelman S, Rowland M, Epstein W L (1970) Griseofulvin-phenobarbital interaction in man. JAMA 213: 426–431

    Article  PubMed  CAS  Google Scholar 

  • Rodin E A, De Sousa G, Haidukewych D, Lodhi R, Berchou R C (1981) Dissociation between free and bound phenytoin levels in presence of valproate sodium. Arch Neurol 38: 240–242

    PubMed  CAS  Google Scholar 

  • Roe T F, Podosin RL, Blaskovics ME (1975) Drug interaction: diazoxide and diphenylhydantoin. J Pediatr 9: 285

    Google Scholar 

  • Rolan P A, Somogyi A W, Drew M J R, Cobain W G, South D, Bochner F (1983) Phenytoin intoxication during treatment with parenteral miconazole. Brit Med J 287: 1760

    Article  CAS  Google Scholar 

  • Rose J Q, Choi H K, Schentag J J, Kimbel W R, Jusko W J (1971) Intoxication caused by interaction of chloramphenicol and phenytoin. JAMA 237: 2630–2631

    Article  Google Scholar 

  • Rosenberry K R, Defusco C J, Mansmann H C Jr, McGeady S J (1983) Reduced theophylline half-life induced by carbamazepine therapy. J Pediat 102: 472–474

    Article  PubMed  CAS  Google Scholar 

  • Ross J R Y, Buley L (1980) Interaction between carbamazepine and warfarin. Br Med J 280: 1415–1416

    Article  PubMed  CAS  Google Scholar 

  • Routledge PA, Kitchell BB, Bjornsson TD, Skinner T, Linnoila M, Shand DG (1980) Diazepam and N-desmethyldiazepam redistribution after heparin. Clin Pharmacol Ther 27: 528–532

    Article  PubMed  CAS  Google Scholar 

  • Routledge P A, Stargel W W, Finn A L, Barchowsky A, Shand D G (1981) Lignocaine disposition in blood in epilepsy. Br J clin Pharmacol 12: 663–666

    PubMed  CAS  Google Scholar 

  • Ryan G M, Matthews P A (1970) Phenytoin metabolism stimulated by loxapine. Drug Intell clin Pharm 11: 428

    Google Scholar 

  • Sandor P, Sellers E M, Khouw V, Fan T (1980) Phenytoin disposition during alcohol ingestion and withdrawal. Clin Pharmacol Ther 27: 283

    Google Scholar 

  • Schmidt D (1975) The effect of phenytoin and ethosuximide on primidone metabolism in

    Google Scholar 

  • patients with epilepsy. J Neurol 209:115–123

    Google Scholar 

  • Sellers E M, Holloway M R (1978) Drug kinetics and alcohol ingestion. Clin Pharmacokinet 3: 440–452

    Article  PubMed  CAS  Google Scholar 

  • Sellers E M, Naranjo C A, Giles H G, Frecker R L, Beeching R N (1980) Intravenous diazepam and oral ethanol interaction. Clin Pharmacol Ther 28: 638–645

    Article  PubMed  CAS  Google Scholar 

  • Shader R I, Anastasios G, Greenblatt D J, Harmatz J S, Divoll Allen M (1978) Impaired absorption of desmethyldazepam from chlorazepate by magnesium-aluminium hydroxide. Clin Pharmacol Ther 24: 308–315

    PubMed  CAS  Google Scholar 

  • Shahidi N T (1968) Acetophenetidin-induced methemoglobinemia. Ann NY Acad Sci 151: 822–831

    PubMed  CAS  Google Scholar 

  • Skovsted L, Kristensen M, Hansen JM, Siersbaek-Nielsen K (1976) The effect of different oral anticoagulants on diphenylhydantoin and tolbutamide metabolism. Acta Med Scand 199: 513–515

    Article  PubMed  CAS  Google Scholar 

  • Sjö O, Hvidberg E F, Naestoft J, Lund M (1975) Pharmacokinetics and side effects of clonazepam and its 7-amino metabolite in man. Eur J clin Pharmacol 8: 249–254

    Article  PubMed  Google Scholar 

  • Solomon H, Abrams WB (1972) Interaction between digitoxin and other drugs in man. Am Heart J 83: 277–280

    Article  PubMed  CAS  Google Scholar 

  • Solomon H M, Schrogie J J (1967) The effect of phenyramidol on the metabolism of diphenylhydantoin. Clin Pharmacol Ther 8: 554–556

    PubMed  CAS  Google Scholar 

  • Solomon H M, Reich S, Spirt N, Abrams W B (1971) Interaction between digitoxin and other drugs in vitro and in vivo. Ann NY Acad Sci 179: 362–369

    Article  PubMed  CAS  Google Scholar 

  • Sotaniemi E A, Pelkonen R O, Ahokas J, Pirttiaho H I, Ahlqvist J (1978) Drug metabolism in epileptics: in vivo and in vitro correlations. Br J clin Pharmacol 5: 71–76

    PubMed  CAS  Google Scholar 

  • Sotaniemi E A, Anttila M, Pelkonen R O, Jarvensivu P, Sundquist H (1979) Plasma clearance of propranolol and sotalol and hepatic drug metabolizing enzyme activity. Clin Pharmacol Ther 26: 153–161

    PubMed  CAS  Google Scholar 

  • Stambaugh J E, Wainer I W, Hemphill D M, Schwartz I (1977) A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone. Lancet 1: 398–399

    Article  PubMed  CAS  Google Scholar 

  • Stambaugh J E, Wainer I W, Schwartz I (1978) The effect of phenobarbital on the metabolism of meperidine in normal volunteers. J Clin Pharmacol 18: 482–490

    PubMed  CAS  Google Scholar 

  • Stenzel E, Boenigk H E, Rambeck B (1978) Methsuximide in the treatment of epilepsy. Epilepsia 19: 114

    Google Scholar 

  • Sutton G, Kupferberg HJ (1975) Isoniazid as an inhibitor of primidone metabolism. Neurology 25: 1179–1181

    PubMed  CAS  Google Scholar 

  • Svendsen T L, Kristensen M B, Hansen J M, Skovsted L (1976) The influence of disulfiram on the half-life and clearance rate of diphenylhydantoin and tolbutamide in man. Eur J clin Pharmacol 9: 439–441

    Article  CAS  Google Scholar 

  • Syversen G B, Morgan J P, Weintraub M, Myers GJ (1977) Acetazolamide-induced interference with primidone absorption: case reports and metabolic studies. Arch Neurol 34: 80–84

    PubMed  CAS  Google Scholar 

  • Taeuber K, Badian M, Brittel H F, Toyen T, Rypp W, Sitting W, Wihlein M (1979) Kinetic and dynamic interaction of clobazam and alcohol. Br J clin Pharmacol 7: 91–97S

    CAS  Google Scholar 

  • Telerman-Toppet N, Duret M E, Coers C (1981) Cimetidine interaction with carbamazepine. Ann Int Med 94: 544

    PubMed  CAS  Google Scholar 

  • Träskman L, Asberg M, Bertilsson L, Cronholm B, Mellstrom B, Neckers LM, Sjoqvist F, Thoren P, Tybring G (1980) Plasma levels of chlorimipramine and its desmethyl-metabolite during treatment of depression. Clin Pharmacol Ther 6: 600–610

    Google Scholar 

  • Vesell E S, Passananti G T, Lee CH (1971) Impairment of drug metabolism by disulfiram in man. Clin Pharmacol Ther 21: 785–792

    Google Scholar 

  • Victor A, Lundbeg P O, Johansson E D B (1977) Induction of sex hormone binding globulin by phenytoin. Br Med J 2: 934–935

    Article  PubMed  CAS  Google Scholar 

  • Vincent F M (1980) Phenothiazine-induced phenytoin intoxication. Ann Intern Med 93: 56–57

    PubMed  CAS  Google Scholar 

  • Waddel WJ, Butler TC (1957) The distribution and excretion of phenobarbital. J Clin Invest 36: 1217–1226

    Article  Google Scholar 

  • Warren J W, Benmaman JD, Braxton B, Wannamaker BB, Levy RH (1980) Kinetics of a carbamazepine-ethosuximide interaction. Clin Pharmacol Ther 28: 646–651

    Article  PubMed  CAS  Google Scholar 

  • Wasserman T H, Phillips T I, Vauraalte G, Urtasun R, Partington J, Kozid D, Schwade J G, Gangji D, Strong J M (1980) Neurotoxicity of misonidazole. Potential modifying role of phenytoin sodium and dexamethasone. Br J Radiol 53: 172–173

    Google Scholar 

  • Wesseling H, Mols-Thurkow I (1975) Interaction of diphenylhydantoin ( DPH) and tolbutamide in man. Eur J Clin Pharmacol 8: 75–78

    Google Scholar 

  • Wilenski A J, Levy R H, Troupin A S, Moretti-Ojemann L, Friel P (1978) Clorazepate kinetics in treated epileptics. Clin Pharmacol Ther 24: 22–30

    Google Scholar 

  • Windorfer A, Sauer W (1977) Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepine and dipropylacetate. Neuropediatrie 8: 29–41

    Article  Google Scholar 

  • Windorfer A, Sauer W, Gaedeke R (1975) Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug. Acta Pediatr Scand 64: 771–772

    Article  Google Scholar 

  • Workman P, Bleehen N M, Wiltshire C R (1980) Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man; implications for possible reduced toxicity. Br J Cancer 41: 302–304

    Article  PubMed  CAS  Google Scholar 

  • Wright J M, Stokes E F, Sweeney V P (1982) Isoniazid-induced carbamazepine toxicity and vice versa. A double drug interaction. N Engl J Med 307: 1225–1227

    Google Scholar 

  • Yokochi K, Yokochi A, Chiba K, Ishizaki T (1982) Phenytoin-allopurinol interaction: Michaelis-Menten kinetic parameters of phenytoin with and without allopurinol in a child with Lesch-Nyhan syndrome. Ther Drug Monit 4: 353–358

    Google Scholar 

  • Zimmerman C L, Patel I H, Levy R H, Edwards D, Nelson S D, Hutchinson M (1981) Protein binding of valproic acid in the presence of elevated free fatty acids in patient and normal human serum. Epilepsia 22: 11–17

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. E. Perucca
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Richens
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Perucca, E., Richens, A. (1985). Antiepileptic Drug Interactions. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69518-6_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69520-9

  • Online ISBN: 978-3-642-69518-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation