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Antiepileptic Drugs pp 601–610Cite as

Acetylurea Derivatives

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Phenacemide (Phenurone, phenylacetylurea) was the prototype of the first group of anticonvulsant substances to depart from the traditional barbiturate, hydantoin, and oxazolidinedione ring structures characteristic of antiepileptic drugs in use prior to 1948. These noncyclic ureides may be considered analogues of their corresponding ring structures. Thus, phenacemide is a straight-chain analogue of 5-phenylhydantoin (opened between the number-5 carbon and the adjacent nitrogen). Other antiepileptic straight-chain analogues of hydantoins, available in various countries, include pheneturide (Benuride), chlorphenacemide (Comitia- don), and acetylpheneturide (Crampol).

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Authors
  1. E. A. Swinyard
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Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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© 1985 Springer-Verlag Berlin Heidelberg

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Swinyard, E.A. (1985). Acetylurea Derivatives. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_22

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69520-9

  • Online ISBN: 978-3-642-69518-6

  • eBook Packages: Springer Book Archive

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