• R. Kretzschmar
  • H. J. Teschendorf
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 74)


Until the introduction of succinimides for therapeutic use in 1960, oxazolidinediones were the drugs of choice in the treatment of petit mal epilepsy. They had been used since 1946. Now the oxazolidinediones are merely of historical interest since their clinical tolerance is unequivocally inferior to that of the succinimides. Nevertheless, their pharmacology deserves detailed consideration since they were the first relatively selective petit mal antiepileptics on which intensive experimental investigations of the type and mechanisms of action were carried out. Several reviews have dealt with oxazolidinediones (Woodbury et al. 1972, 1982; Withrow 1980). For structure-activity relationship see Chap. 9, this volume.


Antiepileptic Drug Anticonvulsant Effect Audiogenic Seizure Maximal Electroshock Anticonvulsant Property 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. Kretzschmar
  • H. J. Teschendorf

There are no affiliations available

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