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Barbituric Acid Derivatives

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Recently, a number of reviews of various aspects of barbiturate pharmacology have appeared (Prichard 1980; Vida 1977; Ho and Harris 1981; Nicoll 1978). These books and reviews more than adequately cover the current understanding of barbiturate anticonvulsant, hypnotic, and tolerance activity at a cellular level and in the whole organism. In order to avoid, as much as possible, a recapitulation of this literature we will take a slightly different approach by focusing primarily upon the anticonvulsant barbiturates and in particular comparing the pharmacology of phenobarbital (PhB) with an experimental anticonvulsant barbituric acid derivative eterobarb (EtB; N, N-dimethoxymethyl phenobarbital). Where appropriate, and as information exists, we will consider the other anticonvulsant barbituric acid derivative, mephobarbital (MB).

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Authors
  1. B. B. Gallagher
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  2. L. S. Freer
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Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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© 1985 Springer-Verlag Berlin Heidelberg

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Gallagher, B.B., Freer, L.S. (1985). Barbituric Acid Derivatives. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69520-9

  • Online ISBN: 978-3-642-69518-6

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