Abstract
During the last few decades ideas on the functions of the enterocytes have undergone significant changes. This concerns primarily the concept of intestinal absorption. However, of hardly less importance for the understanding of the mechanisms of absorption were findings of late 1950s which confirmed the existence of a special type of digestion, membrane digestion, occurring directly on the resorptive surface. Subsequently, in the late 1960s and early 1970s these data led to a view of the enterocyte as a system responsible not only for transport, but also for digestive functions. As will be shown in this chapter, discovery of membrane digestion influenced the two main dogmas of gastroenterology: (1) the two-stage scheme of the alimentary system (luminal digestion-absorption) was replaced by the three-stage scheme (luminal digestion-membrane digestion-absorption); (2) the generally accepted view of digestion being performed in the intestinal lumen and absorption by the intestinal mucosa as two autonomous processes was abandoned. Instead, a concept of the digestive transport conveyor with spatial, time and functional integration of the final stages of digestion and initial stages of absorption on the lipoprotein membrane surface of the enterocytes has been proposed. The purpose of this chapter is to define the role of the hydrolases of the apical membrane of the enterocytes in the function of the transport system. It will be demonstrated that absorption may be controlled by the membrane enzymes in several ways.
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Ugolev, A.M., Iezuitova, N.N., Smirnova, L.F. (1984). Role of Digestive Enzymes in the Permeability of the Enterocyte. In: Csáky, T.Z. (eds) Pharmacology of Intestinal Permeation II. Handbook of Experimental Pharmacology, vol 70 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69508-7_2
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