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Antitumor Drug Resistance pp 101–141Cite as

Cell Cycle Perturbation Effects

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 72))

Abstract

The proliferative status of a cell population and its kinetics of proliferation recovery following treatment with antitumor agents are important determinants in the final outcome of the drug-cell interaction. Antitumor agents generate two types of unrelated effects in treated cells: cell kill and delayed transit through the mitotic cycle (Drewinko and Barlogie 1976 b; Madoc-Jones and Mauro 1975). Therefore, cell proliferation may be decreased because of actual cell kill or because of perturbation of the normal rate of progression through the cycle. This perturbation may be manifested in various forms including cycle stage traverse delay, a reversible or irreversible block in a particular stage of the cycle, or, more commonly, a combination of these factors. This temporary lag in the multiplication rate may increase the doubling time of the treated population and produce results indistinguishable from those obtained in populations whose cells are actually killed (Roper and Drewinko 1976). In addition, the reassortment and new distribution in different proliferative compartments or stages of the cell cycle experienced by the population will influence profoundly the effect of the same or another agent administered at subsequent intervals, thus resulting in either increased or decreased sensitivity to the agent (Dethlefsen 1975, 1979).

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  1. B. Drewinko
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  2. B. Barlogie
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  1. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, M20 9BX, Withington, Manchester, UK

    Brian W. Fox Ph. D.  & Margaret Fox  & 

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Drewinko, B., Barlogie, B. (1984). Cell Cycle Perturbation Effects. In: Fox, B.W., Fox, M. (eds) Antitumor Drug Resistance. Handbook of Experimental Pharmacology, vol 72. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69490-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-69490-5_6

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