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Antibodies to Synthetic Peptides Targeted to the Transforming Genes of Human Adenoviruses: An Approach to Understanding Early Viral Gene Function

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 109)

Abstract

Adenoviruses (Ads) are DNA tumor viruses which contain double–stranded linear DNA genomes of molecular weight 20–25 million (GREEN et al. 1967). There are 31 well–defined human adenoviruses, many of which are ubiquitous in the human population. Adenoviruses commonly cause latent infections of lymphoid tissue and are mainly associated with respiratory disease, which can reach epidemic proportions in closed populations. By DNA homology measurements, human Ads 1–31 are classified into five groups, A through E, containing homologous transforming gene sequences (GREEN et al. 1979 a; MACKEY et al. 1979 a). Although probably all human Ads can transform cells and many can induce tumors in laboratory animals, there is no evidence that they play a significant role in human carcinogenesis. An extensive search was made for the presence of DNA sequences representing each of the five human Ad groups in human tumors representing about 90% of the cancer incidence in the United States. Significant Ad genetic information was not detected under conditions that would have detected less than one transforming gene per tumor cell in most cases (Mackey et al. 1976; Green and Mackey 1977; Green et al 1979b; Mackey et al. 1979b; Wold et al. 1979; Green, unpublished data). Thus, although the human Ads are widespread and have oncogenic potential, their oncogenic potential does not appear to be manifested in their native human host species.

Keywords

Rous Sarcoma Virus Adenovirus Type Human Adenovirus Early Protein Antipeptide Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  1. 1.Institute for Molecular VirologySt. Louis University Medical CenterSt. LouisUSA

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