Morphine which is intrathecally administered interferes with the spinal function by inhibiting the liberation of P substances in the substantia. gelatinosa. The transmission of nociception is blocked at the spinal level [1–3, 7,14,11–13,17, 20, 21, 22]. On the basis of this evidence, it was possible to give spinal anesthesia with morphine for operations followed by very painful postoperative , used in this manner, morphine gives produces exceptional pain relief[7,17,18]. During animal and human trials of intrathecal application of morphine, endesired side effects were not noticed in animals and no narcotics dependence was senn in cancer patients [15,16,18,20,23].