Abstract
Morphine which is intrathecally administered interferes with the spinal function by inhibiting the liberation of P substances in the substantia. gelatinosa. The transmission of nociception is blocked at the spinal level [1–3, 7,14,11–13,17, 20, 21, 22]. On the basis of this evidence, it was possible to give spinal anesthesia with morphine for operations followed by very painful postoperative [5], used in this manner, morphine gives produces exceptional pain relief[7,17,18]. During animal and human trials of intrathecal application of morphine, endesired side effects were not noticed in animals and no narcotics dependence was senn in cancer patients [15,16,18,20,23].
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References
Basbaum Al, Clanton CN, Fields HL (1976) Opiate and stimulus produced analgesia: functional anatomy of a medullo-spinal pathway. Proc Natl Acad Sci USA 73: 4685
Besson JM, Wyon-Maillard MC, Benoist JM, Conseiller C, Hammannk F (1973) Effects of phenoperi- dine on lamina V cells in the cat dorsal horn. J Pharmacol Exp Ther 187: 239
Besson JM (1977) Effets de la morphine sur la transmission des messages nociceptifs au niveau médullaire. Actual Pharmacol (Paris) 119
Devaux CB, Tessier C (1979) Clinical surgery and medullary opiate analgesia. Proceedings of 8th Belgian congress of anesthesiology
Devaux CB, Tessier C (to be published) Comparative hemodynamic studies of morphine anesthesia (sub-Arachnoïd-Epidural). In: Special topic Opiates. 7th World congress of anesthesiologists
Duggam AW, Hall JG, Headley PM (1976) Morphine, enkephalin and the substantia gelatinosa. Nature 264: 456
Glynn CJ, Mather CE, Cousins MJ, Wilson ZR, Graham JR (1979) Spinal narcotics and respiratory depression. Lancet 8138: 356
Haruka A, Kazujei I, Toshimari S, Takehisa S (1981) Segmental effects of morphine injected into epidural space in man. Anesthesiology 54: 75
Kitahata LM, Collins JC (1981) Spinal action of narcotic analgesics. Anesthesiology 54: 153
Lamotte C, Pert CB, Smyder SH (1976) Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section. Brain Res 112: 407
Lebars D, Menetrey D, Conseiller C, Besson JM (1975) Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat. Brain Res 98: 261
Le Bars D, Guilbaud G, Jurna I, Besson JM (1976) Differential affects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat. Brain Res 115: 518
Liolos A, Hartmann A, Andersen F (1979) Selective spinal analgesia. Lancet 8138: 357
Tung AS, Temicella R, Winter PM (1980) Opiate withdrawal syndrome following intrathecal administration of morphine. Anesthesiology 53: 340
Ventafrida V (1980) Cervical. Sub-arachnoidal morphine infusion (abstract). Second worlds congress on pain. Pain 1: 199
Wang JK (1977) Analgesic effect of intrathecally administered morphine. Reg Anesth 2: 3
Wang JK, Mauss IA, Thomas JE (1979) Pain relief by intrathecally applied morphine in man. Anesthesiology 50: 149
Yaksh TL, Rudy TA (1976) Analgesia mediated by a direct spinal action of narcotics. Science 192: 1357
Yaksh TL, Rudy TA (1977) Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 202: 411
Yaksh TL (1978) Inhibition by etorphine of the discharge of dorsal horn neurons: effects on the neuronal response to both high and low threshold sensory input in the cerebral spinal cat. Exp Neurol 60: 23
Zielgans Berger W, Bayerl H (1975) The mechanism of inhibition of neuronal activities by opiates in the spinal cord of cat. Brain Res 115: 111
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Devaux, C.B., Tessier, C. (1984). Clinical Survey of Spinal Anesthesia with Morphine. In: Wüst, H.J., Zindler, M., d’Arcy Stanton-Hicks, M. (eds) Neue Aspekte in der Regionalanaesthesie 3. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69453-0_25
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DOI: https://doi.org/10.1007/978-3-642-69453-0_25
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