Abstract
Many biologic responses secondary to opiate receptor interactions, both in vitro and in vivo, are subject to the development of tolerance. Thus, it would not be surprising to observe a decrease in the antinociceptive response to intrathecal or epidural opiates after prolonged use. Indeed, this phenomenon has been observed both clinically and in experimental animals.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Tung AS, Wang JY, Yaksh TL (to be published) Tolerance to intrathecal opiates in the rat
Yaksh TL, Reddy SVR (to be published) Studies on the analgetic effects of intrathecal opiates, α-adrenergic agonists and baclofen: their pharmacology in the primate. Anesthesiology
Tung AS, Yaksh TL (to be published) Evaluation of epidural opiates in the cat. 8th International congress of pharmacology, Tokyo
Yaksh TL, Kohl RL, Rudy TA (1977) Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space. Eur J Pharmacol 42: 275–284
Tung A, Maliniak K, Tenicela R, Winter PM (1980) Intrathecal morphine for intraoperative and postoperative analgesia. JAMA 244: 2637–2638
Tung AS, Tenicela R, Winter PLM (1980) Opiate withdrawal syndrome following intrathecal administration of morphine. Anesthesiology 53: 340
Ventafridda V, Figliuzzi M, Tamburini M, Gori E, Parolaro D, Sala M (1979) Clinical observation on analgesia elicited by intrathecal morphine in cancer patients. In: Bonica JJ et al (eds) Adv in pain research and therapy, vol 3. Raven, New York, pp 559–565
Lazorthes Y, Gouarderes Ch, Verdie JC, Monsarrat B, Bastide R, Campan L, Alwan A, Cros J (1980) Analgesie par injection intrathecale de morphine etude pharmacocinetique et application aux douleurs irreductibles. Neurochirurgie 26: 159–164
Onofrio B, Yaksh TL, Arnold PG (to be published) Continous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. Mayo Clin Proc
Müller H, Stoyanov M, Dorner U, Hempelmann G (to be published) opiates for relief of cancer pain. In: Yaksh TL, Müller H, Engquist A (eds) Anaesthesia and intensive care medicine. Springer, Berlin Heidelberg New York
Tung AS, Tenicela R, Barr G (to be published) Caudal opiates for pelvic cancer pain
Zenz M, Piepenbrock S, Hilfrich J, Husch M (to be published) Pain therapy with epidural morphine in patients with terminal cancer. In: Yaksh TL, Müller H, Engquist A (eds) Anaesthesia and intensive care medicine. Springer, Berlin Heidelberg New York
Martin WR, Eades CG, Thompson J A, Huppler RD, Gilbert PE (1976) The effects of morphine and nalorphine-like drugs in the non-dependent and morphine dependent chronic spinal dog. J Pharmacol Exp Ther 197: 517–532
Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW (1977) Endogenous opioid peptides: multiple agonists and receptors, Nature 267: 495–499
Fields NL, Emson PC, Leigh BK, Gilbert RFT, Iversen LL (1980) Multiple opiate receptors in primary afferent fibres. Nature 214: 351–352
Tung AS, Yaksh TL (to be published) Involvement of multiple opiate receptors in spinally mediated analgesia. Pain
Reddy SVR, Yaksh TL (1980) Antinociceptive effecs of lanthanum, neodymium and europium following intrathecal administration. Neuropharmacology 19: 181–185
Yaksh TL, Wilson PR (1979) Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther 208: 446–453
Wilson PR, Yaksh TL (1978) Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur J Pharmacol 51: 323–330
Wang J-Y, Yasuoka S, Yaksh TL (to be published) Studies on the analgetic effect of intrathecal ST-91 (2-[2,6-diethylphenylamino]-2-imidazoline): antagonism, tolerance and interaction with morphine. Pharmacologist
Clineschmidt BV, McGuffin JC, Bunting PB (1979) Neurotensin: antinocisponsive action in rodents. Eur J Pharmacol 54: 129–138
Colpaert FC, Niemegeers CJE, Janssen PAJ, Maroli AN (1980) The effects of prior fentanyl administration and of pain on fentanyl analgesia: tolerance to and enhancement of narcotic analgesia. J Pharmacol Exp Ther 213: 418–424
Siegel S, Hinson RE, Krank MD (1980) Morphine-induced attenuation of morphine tolerance. Science 212: 1533–1534
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tung, A.S., Yaksh, T.L. (1984). Studies on the Development of Tolerance Following Spinal Analgetics. In: Wüst, H.J., Zindler, M., d’Arcy Stanton-Hicks, M. (eds) Neue Aspekte in der Regionalanaesthesie 3. Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69453-0_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-69453-0_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13023-9
Online ISBN: 978-3-642-69453-0
eBook Packages: Springer Book Archive