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Studies on the Development of Tolerance Following Spinal Analgetics

  • A. S. Tung
  • T. L. Yaksh
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 158)

Abstract

Many biologic responses secondary to opiate receptor interactions, both in vitro and in vivo, are subject to the development of tolerance. Thus, it would not be surprising to observe a decrease in the antinociceptive response to intrathecal or epidural opiates after prolonged use. Indeed, this phenomenon has been observed both clinically and in experimental animals.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • A. S. Tung
  • T. L. Yaksh

There are no affiliations available

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