Zusammenfassung
Im 20. Jahrhundert ist in den meisten entwickelten Industrieländern ein erheblicher Anstieg der koronaren Herzkrankheiten (KHK) festzustellen, der sich weder ausschließlich mit einer verbesserten kardiologischen Diagnostik, noch mit einer Erhöhung des Lebensalters, noch etwaigen genetischen Veränderungen zufriedenstellend erklären läßt (Michaels 1966; White 1974). Nach dem zweiten Weltkrieg wurde aus verschiedenen amerikanischen epidemiologischen Studien das multifaktorielle ätiologische Konzept der physiko-chemischen koronaren Risikofaktoren (Schaefer u. Blohmke 1977 a) entwickelt, dessen allerdings begrenzte Aussagekraft sich darin zeigt, daß es die in verschiedenen Ländern sehr unterschiedliche Inzidenz an KHK nicht zufriedenstellend erklärt (Keys 1970). Es wurde geschätzt, daß diese Risikofaktoren insgesamt lediglich 25% bis 50% der Varianz aufklären (Marmot u. Winkelstein 1975). Ausgehend von dieser relativ niedrigen Prognosegenauigkeit wurde vermutet, daß es weitere Variablen geben müsse, die als Determinanten für die Entstehung von KHK in Frage kommen könnten (Jenkins 1977). Da die weithin akzeptierte Hypothese einer multifaktoriellen Gense der KHK (Epstein 1965) keineswegs eine Beschränkung auf physiko-chemische Risikofaktoren erfordert, wurde die Zusatzhypothese aufgestellt, daß psychosoziale Variablen ebenfalls das koronare Erkrankungsrisiko erhöhen könnten.
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Langosch, W. (1984). Psychosoziale Aspekte des Herzinfarktes. In: Roskamm, H., et al. Koronarerkrankungen. Handbuch der inneren Medizin, vol 9 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69451-6_6
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DOI: https://doi.org/10.1007/978-3-642-69451-6_6
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