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Digitalis

  • Chapter
Koronarerkrankungen

Part of the book series: Handbuch der inneren Medizin ((INNEREN 9,volume 9 / 3))

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Zusammenfassung

Bei Patienten mit koronarer Herzkrankheit wird die Indikation zu einer Digitalisbehandlung bis heute unterschiedlich beurteilt, sofern keine klinischen Zeichen einer Herzinsuffizienz oder tachykarde supraventrikuläre Rhythmusstörungen bestehen.

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Literatur

  • Amsterdam EA, Kamiyama T, Rendig S, Mason DT (1974) Differential regional contrac- tile actions of digitalis in experimental myocardial infarction. Clin Res 22: 257 (abstr)

    Google Scholar 

  • Amsterdam EA, de Maria AN, Miller RR, Awan NA, Mason DT (1976) Enhancement of left ventricular function in chronic ischemic heart diseease by digitalis. Circulation 54 [Suppl II]: 212 (abstr)

    Google Scholar 

  • Banka VS, Chadda KD, Bodenheimer MM, Helfant RH (1975) Digitalis in experimental acute myocardial infarction. Differential effects on contractile Performance of ischemic, border and nonischemic ventricular zones in the dog. Am J Cardiol 35: 801–808

    Google Scholar 

  • Banka VS,, Yamazaki H, Agarwal JB, Bodenheimer MM, Helfant RH (1982) Effects of digitalis on subendocardial and subepicardial dysfunction during acute ischemia. Circulation 65: 1315–1320

    Article  PubMed  CAS  Google Scholar 

  • Bing RJ, Maraist FM, Dammann JF, Draper A, Heimbecker R, Daley R, Gerard R, Calazel P (1950) Effect of strophanthus on coronary blood flow and cardiac oxygen consumption of normal and failing human hearts. Circulation 2: 513–517

    PubMed  CAS  Google Scholar 

  • Bolte HD (1978) Therapie mit Betarezeptorenblockern bei koronarer Herzerkrankung. Internist 19: 520–526

    PubMed  CAS  Google Scholar 

  • Brandt D, Klein W (1977) Der Einfluß von K-Strophanthin auf Haemodynamik und Stoffwechsel bei Patienten mit Angina pectoris. Z Kardiol [Suppl 4] 66: 33

    Google Scholar 

  • Chamberlain DA (1966) Effects of beta-adrenergic blockade on heart size. Am J Cardiol 18: 321–324

    Article  PubMed  CAS  Google Scholar 

  • Covell JW, Braunwald E, Ross J Jr, Sonnenblick EH (1966) Studies on digitalis. XVI. Effects on myocardial oxygen consumption. J Clin Invest 45: 1535–1542

    Google Scholar 

  • Crawford MH, LeWinter MM, O’Rourke RA, Karliner JS, Ross J J r (1975) Combined propranolol and digoxin therapy in angina pectoris. Ann Intern Med 83: 449–455

    PubMed  CAS  Google Scholar 

  • DeMots H, Rahimtoola SH, Kremkau EL, Bennett W, Mahler D (1976) Effects of ouabain on myocardial oxygen supply and demand in patients with chronic coronary artery disease. J Clin Invest 58: 312–319

    Article  Google Scholar 

  • DeMots H, Rahimtoola SH, McAnulty JH, Porter GA (1978) Effects of ouabain on coronary and systemic vascular resistance and myocardial oxygen consumption in patients without heart failure. Am J Cardiol 41: 88–93

    Article  Google Scholar 

  • Duner H, Pernow B (1973) Haemodynamic effects of ß-receptor blocking agents and digitalis in ischaemic coronary heart disease with angina pectoris. Acta Med Scand 194: 517–520

    Article  PubMed  CAS  Google Scholar 

  • Edens E (1934) Die Strophanthinbehandlung der Angina pectoirs. Muench Med Wochenschr 81: 1421–1427

    Google Scholar 

  • Ekelund LG, Johnsson G, Melcher A, Orö L (1973) Effects of Cedilanid-D and Alprenolol in angina pectoris. Eur J Clin Pharmacol 6: 113 — 118

    Article  PubMed  CAS  Google Scholar 

  • Ferlinz J, Del Vicario M, Aronow WS (1978) Effects of rapid digitalization on total and regional myocardial performance in patients with coronary artery disease. Am Heart J 96:337-–346

    Google Scholar 

  • Ferlinz J, Siegel J, van Herick R, Aronow WS (1979) Myocardial metabolism and threshold to angina in coronary artery disease after digitalization. Am J Med 66: 288–295

    Article  PubMed  CAS  Google Scholar 

  • Firth BG, Dehmer GJ, Corbett JR, Levis SE, Parkey RW, Willerson JT (1980) Effect of chronic oral digoxin therapy on ventricular function at rest and peak exercise in patients with ischemic heart disease. Am J Cardiol 46: 481–490

    Article  PubMed  CAS  Google Scholar 

  • Garan H, Smith TW, Powell WJ Jr. (1974) The central nervous system as a site of action for the coronary vasoconstrictor effect of digoxin. J Clin Invest 54: 1365–1372

    Article  PubMed  CAS  Google Scholar 

  • Gebhardt W, Blümchen G (1968) Hemodynamic effect of a combined therapy with propranolol and digoxin. Cardiologia 52: 190–195

    Article  PubMed  CAS  Google Scholar 

  • Glancy DL, Higgs LM, O’Brien KP, Epstein SE (1971) Effects of ouabain on the left ventricular response to exercise in patients with angina pectoris. Circulation 43: 45–57

    PubMed  CAS  Google Scholar 

  • Gold H, Otto H, Kwit NT (1938) Does digitalis influence the course of cardiac pain? A study of 120 selected cases of angina pectoris. J Am Med Ass 110: 859–863

    Article  Google Scholar 

  • Gross GJ, Warltier DC, Hardman HF, Somani P (1977) The effect of ouabain on nutritional circulation and regional myocardial blood flow. Am Heart J 93: 487–495

    Article  PubMed  CAS  Google Scholar 

  • Hamlin NP, Willerson JT, Garan H, Powell WJ Jr (1974) The neurogenic vasoconstrictor effect of digitalis on coronary vascular resistance. J Clin Invest 53: 288–296

    Article  PubMed  CAS  Google Scholar 

  • Harding PR, Aronow WS, Eisenman J (1973) Digitalis as an antianginal agent. Chest 64: 439–443

    Article  PubMed  CAS  Google Scholar 

  • Harrison LA, Blaschke J, Phillips RS, Price WE, Cotton MV, Jacobson ED (1969) Effects of ouabain on the splanchnic circulation. J Pharmacol Exp Ther 169: 321–327

    PubMed  CAS  Google Scholar 

  • Helfant RH, Herman MV, Gorlin R (1971) Abnormalities of left ventricular contraction induced by beta adrenergic blockade. Circulation 43: 641–647

    PubMed  CAS  Google Scholar 

  • Higgs LM, Glancy DL, O’Brien KP, Epstein SE (1971) Effects of ouabain on the left ventricular response to atrial pacing in patients with angina pectoris. Am J Cardiol 28: 17–24

    Article  PubMed  CAS  Google Scholar 

  • Kleiman JH, Ingels NB, Daughters G, Stinson EB, Alderman EL, Goldman RH (1978) Left ventricular dynamics during long-term digoxin treatment in patients with stable coronary artery disease. Am J Cardiol 41: 937–942

    Article  PubMed  CAS  Google Scholar 

  • Klein WW, Brandt D, Pavek P (1977) Effekt von K-Strophanthin auf Haemodynamik und Stoffwechsel des koronarkranken Herzens in Ruhe und während frequenzinduzierter Angina pectoris. Verh Dtsch Ges Inn Med 83: 1647–1650

    Google Scholar 

  • Kötter V, Schüren KP, Schröder R (1977 a) Der Einfluß von Digoxin auf Coronardurch- blutung und myokardialen 02-Verbrauch bei Patienten mit Angina pectoris. Verh Dtsch Ges Inn Med 83: 1644–1647

    Google Scholar 

  • Kötter V, v. Leitner E, Kuhlmann J, Schröder R (1977 b) Vergleich der Auswirkungen von Digoxin und Canrenoat-Kalium auf die Haemodynamik und Infarktgröße von Hunden mit großen Myokardinfarkten. Herz/Kreisl 9: 208–212

    Google Scholar 

  • Kötter V, Schüren KP, Schröder R (1978 a) Effect of digoxin on coronary blood flow and myocardial oxygen consumption in patients with chronic coronary artery disease. Am J Cardiol 42: 563–569

    Google Scholar 

  • Kötter V, Schüren KP, Schröder R (1978 b) Auswirkungen einer kombinierten Digoxin- Metoprolol-Therapie auf metabolische und haemodynamische Parameter bei Patienten mit Angina pectoris. Dtsch Ges Kreislaufforschg, Herbsttagung Berlin Lehmann HU, Witt E, Hochrein H (1978) Zunahme von Angina pectoris und ST-Strekkensenkung im EKG durch Digitalis. Z Kardiol 67: 57–66

    Google Scholar 

  • LeWinter M, Crawford M, Karliner J, Ross J Jr, O’Rourke R (1974) Differing effects of propranolol, digoxin and combined therapy in patients with angina pectrois. Am J Cardiol 33: 151 (abstr)

    Google Scholar 

  • Loeb HS, Streitmatter N, Braunstein D, Jacobs WR, Croke RP, Gunnar RM (1979) Lack of ouabain effect on pacing-induced myocardial ischemia in patients with coronary artery disease. Am J Cardiol 43: 995–1000

    Article  PubMed  CAS  Google Scholar 

  • Malmbourg RO (1965) A clinical and hemodynamic analysis of factors limiting the cardiac performance in patients with coronary heart disease. Acta Med Scand [Suppl 426] 177: 46–47

    Google Scholar 

  • Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr, Braunwald E (1971) Factors influencing infarct size following experimental coronary artery occlusion. Circulation 43: 67–82

    PubMed  CAS  Google Scholar 

  • Mason DT (1973) Digitalis and angina pectoris. Chest 64:415-–416 Mason DT, Braunwald E, Karsh RB, Bullock FA (1964) Studies on digitalis. X. Effects of ouabain on forearm vascular resistance and venous tone in normal subjects and in patients with heart failure. J Clin Invest 43: 532–543

    Google Scholar 

  • Mason DT, Spann JF, Zelis R (1969) New developments in the understanding of the actions of the digitalis glycosides. Prog Cardiovasc Dis 11: 443–478

    Article  PubMed  CAS  Google Scholar 

  • Master AM, Jaffe HL, Dack S (1939) The drug treatment of angina pectoris due to coronary artery disease. Am J Med Sei 197: 774–782

    Article  Google Scholar 

  • Nelson GR, Sonnenblick EH, Kirk ES (1975) Mechanism of salutary effects of digitalis on myocardial ischemia with failure. Clin Res 23: 382

    Google Scholar 

  • O’Rourke RA, Henning H, Theroux P, Crawford MH, Ross J Jr (1976) Favorable effects of orally administered digoxin on left heart size and ventricular wall motion in patients with previous maocardial infarction. Am J Cardiol 37: 708–715

    Article  PubMed  Google Scholar 

  • Parker JO, West RO, Ledwich JR, DiGiorgi S (1969) The effect of acute digitalization on the hemodynamic response to exercise in coronary artery disease. Circulation 40: 453–462

    PubMed  CAS  Google Scholar 

  • Puri PS (1974) Modification of experimental myocardial infarct size by cardiac drugs. Am J Cardiol 33: 521–528

    Article  PubMed  CAS  Google Scholar 

  • Raina S, Banka VS, Ramanathan K, Bodenheimer MM, Helfant RH (1978) Beneficial effects of propranolol and digitalis on contraction and ST-segment elevation after acute coronary occlusion. Am J Cardiol 42: 226–233

    Article  PubMed  CAS  Google Scholar 

  • Riseman JEF, Brown MG (1937) Medical treatment of angina pectoris. Arch Intern Med 60: 100–18

    Article  Google Scholar 

  • Ross J Jr, Waldhausen JA, Braunwald E (1960) Studies on digitalis. I. Direct effects on peripheral vascular resistance. J Clin Invest 39: 930–936

    Google Scholar 

  • Sagar KB, Hnson EC, Powell WJ (1977) Neurogenic coronary vasoconstrictor effects of digitalis during acute global ischemia in dogs. J Clin Invest 60: 1248–1257

    Article  PubMed  CAS  Google Scholar 

  • Schüren KP, Kötter V, Schröder R (1980) Digitalis und koronare Herzkrankheit. Z Kardiol 69: 319–328

    PubMed  Google Scholar 

  • Sharma B, Majid PA, Meeran MK, Whitaker W, Taylor SH (1972) Clinical, electrocardiographic, and haemodynamic effects of digitalis (ouabain) in angina pectoris. Br Heart J 34: 631–637

    Article  PubMed  CAS  Google Scholar 

  • Smith HJ, Bouvaros GA, McGregor M (1966) Failure of acute digitalization to influence exercise tolerance in angina pectoris. Br Med J 1: 1337–1338

    Article  PubMed  CAS  Google Scholar 

  • Somberg JC, Kuhlman JE, Smith TW (1981) Localization of the neurally mediated coronary vasoconstrictor properties of digitalis in the cat. Circ Res 49: 226–233

    PubMed  CAS  Google Scholar 

  • Tauchert M, Behrenbeck DW, Hötzel J, Hilger HH (1977) Der Einfluß von Digoxin auf den myokardialen Sauerstoffverbrauch bei koronarer Herzkrankheit. Verh Dtsch Ges Inn Med 83:1641-–1644

    Google Scholar 

  • Vatner SF, Baig H (1978) Comparison of the effects of ouabain and isoproterenol on ischemic myocardium of conscious dogs. Circulation 58: 654–662

    PubMed  CAS  Google Scholar 

  • Vatner SF, Higgins CB, Franklin D, Braunwald E (1971) Effects of digitalis glycoside on coronary and systemic dynamics in conscious dogs. Circ Res 28: 470–479

    PubMed  CAS  Google Scholar 

  • Vatner SF, Baig H, Manders WT, Murray PA (1978) Effects of a cardiac glycoside in combination with propranolol on the ischemic heart of conscious dogs. Circulation 57: 568–575

    PubMed  CAS  Google Scholar 

  • Vogel R, Frischknecht J, Steele P (1977 a) Short- and long-term effects of digitalis on resting and posthandgrip hemodynamics in patients with coronary artery disease. Am J Cardiol 40: 171–176

    Google Scholar 

  • Vogel R, Kirch D, LeFree M, Frischknecht J, Steele P (1977 b) Effects of digitalis on resting and isometric exercise myocardial perfusion in patients with coronary artery disease and left ventricular dysfunction. Circulation 56: 355–359

    Google Scholar 

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© 1984 Springer-Verlag Berlin Heidelberg

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Schüren, K.P. (1984). Digitalis. In: Roskamm, H., et al. Koronarerkrankungen. Handbuch der inneren Medizin, vol 9 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69451-6_36

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  • DOI: https://doi.org/10.1007/978-3-642-69451-6_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69452-3

  • Online ISBN: 978-3-642-69451-6

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