Molecular Aspects of Cell Membranes as Substrates for Interaction with Electromagnetic Fields

  • W. R. Adey
Conference paper
Part of the Springer Series in Synergetics book series (SSSYN, volume 23)

Abstract

Important new questions have arisen concerning the role of the cell membrane in sensing the electrochemical environment which bathes it, and about ways in which these signals in surrounding fluid may be conveyed from the cell surface to its interior. For more than one hundred years, models of cell membranes have focused on the lipid bilayer or plasma membrane as the essential structural element separating intracellular contents from surrounding fluid. Although this original concept remains valid, there is a new awareness that cell membranes are far more complex. They must detect a wide variety of cell surface stimuli that inlcude neurotransmitter molecules, antibodies and most hormones. From these first events, signals passing to the cell interior initiate a vast spectrum of processes, many associated with release of metabolic energy. In this transductive coupling across the cell membrane, intracellular responses are triggered at energy levels far higher than in the initial cell surface event.

Keywords

Migration Microwave Lymphoma Amide Soliton 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S.J. Singer, G.W. Nicolson: Science 175, 729–731 (1972)ADSCrossRefGoogle Scholar
  2. 2.
    R.K. Gershon: New England J. Med. 300, 1105–1107 (1979)CrossRefGoogle Scholar
  3. 3.
    H. Hyden: Proc. Natl. Acad. Sci. USA 71, 2966–2968 (1975)Google Scholar
  4. 4.
    G.M. Edelman: Science 192, 218–226 (1976)ADSCrossRefGoogle Scholar
  5. 5.
    H.-A. Hansson: Brain Res. 216, 187–191 (1981)ADSCrossRefGoogle Scholar
  6. 6.
    H.-A. Hansson: Med. Biol. 59, 103–110 (1981)Google Scholar
  7. 7.
    J.M.R. Delgado, J. Leal, J.L. Monteagudo, M.G. Garcia: J. Anat. London 134, 533–552 (1982)Google Scholar
  8. 8.
    W.R. Adey: “Ionic Nonequilibrium Phenomena in Tissue Interactions with Electromagnetic Fields”, in Biological Effects of Nonionizing Radiation, ed. by K.H. Illinger, Symposium Series, No.157 (American Chemical Society, Washington, D.C. 1981) pp.271–297CrossRefGoogle Scholar
  9. 9.
    W.R. Adey: Physiol. Rev. 61, 438–514 (1981)Google Scholar
  10. 10.
    R. Dixey, G. Rein: Nature 296, 253–256 (1982)ADSCrossRefGoogle Scholar
  11. 11.
    W.R. Adey: “Biological Effects of Low Energy Electromagnetic Fields on the Central Nervous System”, in Biological Effects and Dosimetry of Nonionizing Radiation, ed. by M. Grandolfo, S.M. Michaelson, A. Rindi (Plenum, New York 1983) pp.359–391Google Scholar
  12. 12.
    A.F. Lawrence, W.R. Adey: Neurol. Res. 4, 115–153 (1982)Google Scholar
  13. 13.
    W. Grundler, W.F. Keilmann, H. Frohlich: Phys. Lett. 62A, 463–466 (1977)Google Scholar
  14. 14.
    W. Grundler, F. Keilmann, D. Strube, I. Zimmermann: Nature, in press (1983)Google Scholar
  15. 15.
    L.K. Kaczmarek, W.R. Adey: Brain Res. 66, 537–540 (1974)CrossRefGoogle Scholar
  16. 16.
    S.M. Bawin, L.K. Kaczmarek, W.R. Adey: Ann. NY Acad. Sci. 247, 74–81 (1975)ADSCrossRefGoogle Scholar
  17. 17.
    C.S. Blackman, J.A. Elder, G.M. Weil, S.G. Benane, D.C. Eichinger, D.E. House: Radio Sci. 14, 93–98 (1979)ADSCrossRefGoogle Scholar
  18. 18.
    S.M. Bawin, W.R. Adey: Proc. Natl. Acad. Sci. USA 73, 1999–2003 (1976)ADSCrossRefGoogle Scholar
  19. 19.
    C.S. Blackman, S.G. Benane, D.E. House, W.T. Joines, R.J. Spiegel: Proc. Bioelectromagnetics Soc. 4th Annual Meeting, p.30 (1982)Google Scholar
  20. 20.
    A. Katchalsky: “Polyelectrolytes and their Biological Interactions”, in Connective Tissue: Intercellular Macromolecules, ed. by New York Heart Assocn. (New York Heart Assocn., New York 1964) pp.9–42Google Scholar
  21. 21.
    S.M. Bawin, A.R. Sheppard, W.R. Adey: Bioelectrochem. Bioenergetics 5, 67–76 (1978)CrossRefGoogle Scholar
  22. 22.
    C.S. Blackman, S.G. Benane, L.S. Kinney: Proc. Bioelectromagnetics Soc, 3rd Annual Meeting, p.47 (1981)Google Scholar
  23. 23.
    S. Lin-Liu, W.R. Adey: Bioelectromagnetics 3, 309–322 (1982)CrossRefGoogle Scholar
  24. 24.
    W.R. Adey, S.M. Bawin, A.F. Lawrence: Bioelectromagnetics 3, 295–307 (1982)CrossRefGoogle Scholar
  25. 25.
    J.L. Schwartz, J. Delorme, G.A.R. Mealing: Biophys. J. 41, 295a (1983)Google Scholar
  26. 26.
    R.A. Luben, C.D. Cain, M.C.-Y. Chen, D.M. Rosen, W.R. Adey: Proc. Natl. Acad. Sci. USA 79, 4180–4184 (1982)ADSCrossRefGoogle Scholar
  27. 27.
    W.B. Jolley, D.B. Hinshaw, Knierim, D.B. Hinshaw: Bioelectromagnetics 4, 103–106 (1983)CrossRefGoogle Scholar
  28. 28.
    J.R. Lymangrover, E. Keku, Y.J. Seto: Life Sciences 32, 691–696 (1982)CrossRefGoogle Scholar
  29. 29.
    Y.J. Seto, S.T. Hsieh: Biotech. Bioeng. 18, 813–837 (1976)CrossRefGoogle Scholar
  30. 30.
    Y.J. Seto, S.T. Hsieh: Biotech. Bioeng. 20, 455–459 (1978)CrossRefGoogle Scholar
  31. 31.
    D.B. Lyle, P. Schechter, W.R. Adey, R.L. Lundak: Bioelectromagnetics 4(2) (1983)Google Scholar
  32. 32.
    W.R. Adey, S.M. Bawin (eds.): Brain Interactions with Weak Electric and Magnetic Fields, Neurosci. Res. Program Bull. 15, 1–161 (1977)Google Scholar
  33. 33.
    W.R. Adey: Proc. IEEE 68, 119–125 (1980)CrossRefGoogle Scholar
  34. 34.
    I.T. Grodsky: Math. Biosci. 28, 191–219 (1976)MATHCrossRefGoogle Scholar
  35. 35.
    W.R. Adey: Environ. Health Perspec, in press (1983)Google Scholar
  36. 36.
    A.S. Davydov: Biology and Quantum Mechanics (in Russian) (Nauka, Kiev 1979)Google Scholar
  37. 37.
    J.M. Hyman, D.W. McLaughlin, A.C. Scott: Physica D 30, 23–44 (1981)ADSCrossRefGoogle Scholar
  38. 38.
    A.C. Scott: Phys. Lett. 86A, 60–62 (1981)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • W. R. Adey
    • 1
    • 2
    • 3
  1. 1.Research ServicePettis Memorial Veterans HospitalLoma LindaUSA
  2. 2.Department of Surgery, School of MedicineLoma Linda UniversityLoma LindaUSA
  3. 3.Department of Physiology, School of MedicineLoma Linda UniversityLoma LindaUSA

Personalised recommendations