Advertisement

Ventilatory Depression During and after Infusions of Fentanyl and Alfentanyl in Man

  • C. J. H. Andrews
  • M. Sinclair
  • A. Dye
  • J. Dye
  • J. Harvey
  • C. Prys-Roberts
Part of the European Academy of Anaesthesiology book series (ANAESTHESIOLOGY, volume 3)

Abstract

Fentanyl was infused at 3 μg/kg during, and for 1–2 hrs. after anaesthesia and surgery in 7 patients, and alfentanyl was similarly infused at 20 μg/kg/hr in 8 patients. The effects of such infusions on ventilation were measured pre-operatively, 1 hour after the end of anaesthesia, and one hour after termination of the infusion. At each stage, minute (VE) and tidal ventilation (VT), ventilatory frequency (f), and mixed venous Pco2 were measured, and CO2 responsiveness was estimated from the slope,and intercept (VE at Pco2 = 55 mm2 Hg), of the CO2 rebreathing curve. Plasma concentrations of faentanyl methods. All values are presented as mean ± standard error. During fentanyl infusion (PcF = 2.62 ± 0.29 ng/ml), one hour after anaesthesia, VE was 6.6 ± 0.8 1/min and 15.9 ± 1.5 bpm pre-operatively. One hour after termination of the infusion VE was 6.6 ± 0.6 1/min and f was 13.1 ± 1.8 bpm. During the infusion the slopes and intercepts of the CO2 response curves were decreased to 40.1 ± 7.2% and 43.9 ± 6.2% respectively of the pre-operative value (P < 0.02), increasing to 58.4 ± 10.2% and 54.4 ± 5.0% respectively one hour after terminating the infusion (P < 0.01). During infusion of alfentanyl (PcA 121.8 ± 38 ng/ml), one hour after anaesthesia, VE was 5.3 ± 0.6 1/min and f was 9.9 ± 0.7 bpm compared with values of 7.3 ± 0.5 1/min and 10.2 ± 1.3 bpm pre-operatively. One hour after termination of the infusion VE was 6.8 ± 0.6 1/min and f was 12.0 ±1.1 bpm. During infusion the slopes and intercepts of the CO2 response curves were decreased to 48.1 ± 11.6% and 50.3 ± 7.8% respectively of the pre-operative values (P < 0.02) increasing to 68.5 ± 11.2% and 68.8 ± 6.2% respectively one hour after termination of the infusion (P < 0.05).

Keywords

Public Health Standard Error Plasma Concentration Response Curve Venous Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • C. J. H. Andrews
  • M. Sinclair
  • A. Dye
  • J. Dye
  • J. Harvey
  • C. Prys-Roberts

There are no affiliations available

Personalised recommendations