Abstract
Analysis of the texture and distribution of chromatin in cell nuclei has resulted in the recognition and differentiation of: (i) different types of normal cells, (ii) cells in different stages of the cell cycle, (iii) neoplastic cells in various stages of differentiation, and (iv) cells altered by irradiation, chemicals and biological treatment [1–14]. The differentiation may be made by an analysis of chromatin stained in stoechiometric process with the Schiff stain using the Feulgen procedure. The information resides in the condensation, granularity and general spatial arrangement of the stained chromatin [15–16]. Small, gradual changes in the organization of the chromatin reflect changes in the normal physiology, maturity and differentiation of the cells [15–18].
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References
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© 1984 Springer-Verlag Berlin Heidelberg
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Olson, G.B., Bartels, P.H. (1984). Assessment of Environmental Insults on Lymphoid Cells as Detected by Computer Assisted Morphometric Techniques. In: Eisert, W.G., Mendelsohn, M.L. (eds) Biological Dosimetry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69334-2_18
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DOI: https://doi.org/10.1007/978-3-642-69334-2_18
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