Abstract
Since the beginning of biological time the alteration of genetic information through mutation has been a threat and a salvation: a threat to survival because of loss of essential function; and a salvation by providing the degrees of freedom with which selection caused genetic diversity and evolution. Geneticists and more recently molecular biologists have been fascinated by the mechanisms of mutation and repair. Now regulators and public health authorities have been drawn into the subject out of concern that contemporary chemically-oriented societies may be genetically toxic to somatic cells thereby causing cancer or to germinal cells thereby causing heritable defects and a lessening in quality of the human gene pool.
Work performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under contract number W-7405-ENG-48
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Mendelsohn, M.L. (1984). Biological Dosimetry of Mutagenesis: Principles, Methods, and Cytometric Prospects. In: Eisert, W.G., Mendelsohn, M.L. (eds) Biological Dosimetry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69334-2_13
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DOI: https://doi.org/10.1007/978-3-642-69334-2_13
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