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Detection of Male Reproductive Abnormalities by Flow Cytometry Measurements of Testicular and Ejaculated Germ Cells

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Biological Dosimetry

Abstract

The sequence of biochemical and morphological events that characterize the cellular pathway leading from the diploid spermatogonia to mature haploid sperm represents one of the most dramatic differentiation pathways in biology. Table 1 illustrates some of the reporductive tract events within this differentiation pathway that can be modified by environmental agents. Some of the specific events underlying sperm maturation currently under investigation in this laboratory include studies on macromolecular synthesis, meiosis, exchange of nuclear histones for protamines, disulfide bonding and sperm head shaping as they are influenced by mutagens and other environmental factors.

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Author information

Author notes

  1. Donald P. Evenson

    Present address: Chemistry Department, South Dakota State University, Box 2170, Brookings, South Dakota, 57007, USA

Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA

    Donald P. Evenson, Paul J. Higgins & Myron R. Melamed

Authors
  1. Donald P. Evenson
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  2. Paul J. Higgins
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  3. Myron R. Melamed
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Editor information

Editors and Affiliations

  1. Arbeitsgruppe Zytometrie, Gesellschaft für Strahlen- und Umweltforschung mbH, Herrenhäuser Straße 2, 3000, Hannover 21, Germany

    Wolfgang G. Eisert

  2. Biologische Forschung, Dr. K. Thomae GmbH, 7950, Biberach-Riss, Germany

    Wolfgang G. Eisert

  3. Biomedical Sciences Division, Lawrence Livermore National Laboratory, P.O. Box 5570, 94550, Livermore, CA, USA

    Mortimer L. Mendelsohn

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© 1984 Springer-Verlag Berlin Heidelberg

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Evenson, D.P., Higgins, P.J., Melamed, M.R. (1984). Detection of Male Reproductive Abnormalities by Flow Cytometry Measurements of Testicular and Ejaculated Germ Cells. In: Eisert, W.G., Mendelsohn, M.L. (eds) Biological Dosimetry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69334-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-69334-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12790-1

  • Online ISBN: 978-3-642-69334-2

  • eBook Packages: Springer Book Archive

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