The Growth and Differentiation of Human Endothelial Cells

  • T. Maciag
  • R. Weinstein
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The non-thrombogenic nature of veins, arteries and capillaries is maintained in vivo by the presence of the endothelial cell. It has been widely recognized that the identification of factors which influence the growth and differentiation of the endothelial cell will significantly contribute to a better understanding of normal and pathological events in human biology in which the vascular tree has a major impact. These events include tumor growth, atherosclerosis, wound healing, thrombosis and hemostasis. Unfortunately, endothelial cells of human origin have been difficult to study because of their low mitotic index in vivo (1,2). In spite of these difficulties, efficatious methods have been developed for the isolation and propagation of endothelial cells in vitro (3,4,5,6 and 7).


Nerve Growth Factor Human Umbilical Vein Endothelial Cell Tubular Structure Human Factor VIII Human Plasmin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • T. Maciag
    • 1
  • R. Weinstein
    • 2
  1. 1.Department of PathologyCharles A. Dana Research Institute, Harvard-Thorndike Laboratory, Harvard Medical School, Beth Israel HospitalBostonUSA
  2. 2.Department of MedicineCharles A. Dana Research Institute, Harvard-Thorndike Laboratory, Harvard Medical School, Beth Israel HospitalBostonUSA

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