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TCGF-Dependent Growth of Naturally Autoreactive Cells: Regulatory Role of the Thymus

  • Carlo Riccardi
  • Graziella Migliorati
  • Luigi Frati
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Culture of non-immune spleen cells in the presence of T-cel1-growth-factor (TCGF) generate Natural Killer (NK) cells with autoreactive activity against syngeneic normal non-neoplastic cells. These cells are under thymic control. The possible relevance of these observations is discussed.

Keywords

Spleen Cell Mouse Spleen Cell Limit Dilution Assay Culture Spleen Cell Autoreactive Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    C. Riccardi, P. Puccetti, A. Santoni and R.B. Herberman., J. Natl. Cancer Inst., 63, 1041, 1979PubMedGoogle Scholar
  2. 2.
    C. Riccardi, A. Santoni, T. Barlozzari and R.B. Herberman. Cellular Immunology, 60, 136, 1981PubMedCrossRefGoogle Scholar
  3. 3.
    C. Riccardi, B.M. Vose and R.B. Herberman., In “NK Cells and Other Natural Effector Cells” R.B. Herberman (Ed.) Academic Press, N.Y., 909, 1982Google Scholar
  4. 4.
    L.R. Ruben., In “Immune Regulation: Evolutionary and Biological Significance”. L.R. Ruben and M.E. Gershwin (Eds.) Marcel Dekker Inc. N.Y., vol. 17, 217, 1982Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Carlo Riccardi
    • 1
    • 2
  • Graziella Migliorati
    • 1
    • 2
  • Luigi Frati
    • 1
    • 2
  1. 1.Institute of PharmacologyUniversity of PerugiaItaly
  2. 2.Institute of PathologyUniversity of RomeItaly

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