Butyrate-Induced Growth Arrest of GH3-Cells is not Linked to a Distinct Morphological Phenotype

  • Georg Tschank
  • Gerd Brunner
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


N-butyric acid is known to be a potent proliferation-inhibitor of a great number of cell types, both normal and neoplastic (1). In many cases growth arrest is accompanied by striking changes in morphology, e.g. formation of cell processes or increased spreading (1). These changes can be traced back to altered glycolipide and glycoprotein patterns of the plasma membrane and to a reorganization of the cytoskeleton (2, 3).


Sodium Butyrate Newborn Calf Serum Cell Cycle Kinetic Vimentin Filament Special Culture Condition 
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    Prasad, K.N., Sinha, P.K. 1976. Effect of sodium butyrate on mammalian cells in culture. A review. In Vitro 12, 125–132.PubMedCrossRefGoogle Scholar
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    Henneberry, R.C., Fishman, P.H. 1976. Morphological and biochemical differentiation in HeLa cells. Exp. Cell Res. 103, 55–62.PubMedCrossRefGoogle Scholar
  3. 3).
    Hormia, M. et al. 1982. Vimentin filaments in cultured endothelial cells form butyrate-sensitive juxtanuclear masses after repeated subculture. Exp. Cell Res. 138, 159–166.PubMedCrossRefGoogle Scholar
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    Hayashi, I., Larner, J., Sato, G. 1978. Growth control of cells in culture. In Vitro 14, 23–30.PubMedCrossRefGoogle Scholar
  5. 5).
    Tschank, G., Stöhr, M., Brunner, G., in preparation.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Georg Tschank
    • 1
  • Gerd Brunner
    • 1
  1. 1.Institut für ImmunologieJohannes Gutenberg UniversitätMainzGermany

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