Hormonal Regulation of Growth and Function of Insulin-Producing Cells in Culture

  • J. Høiriis Nielsen
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The endocrine pancreas in mammals is organized in numerous small clusters of cells, the islets of Langerhans, consisting of 1000–3000 cells of which the insulin-producing beta-cells amount to about 60–70%. The islets represent only 1–2% of the total pancreas, and it was not before the introduction of the collagenase digestion technique (Moskalewski, 1965) that larger quantities of isolated pancreatic islets could be obtained for biochemical studies (for a review, see Nielsen and Lernmark, 1983).


Growth Hormone Beta Cell Pancreatic Islet Insulin Release Insulin Content 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • J. Høiriis Nielsen
    • 1
  1. 1.Hagedorn Research LaboratoryGentofteDenmark

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