Guanylate Cyclase Activators Hemin and Sodium Nitroprusside Stimulate the Growth of Transformed Cells in Serum-Free Medium

  • P. Basset
  • J. Zwiller
  • G. Ulrich
  • M. O. Revel
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Hemin and sodium nitroprusside, which strongly activate purified guanylate cycclase in vitro, were also found to stimulate leukemic, glioma and neuroblastoma cells to divide in serum-free medium. The involvement of guanylate cyclase activation in the proliferative response to hemin and sodium nitroprusside is discussed.


Nitric Oxide Fetal Calf Serum Neuroblastoma Cell Growth Promotion Sodium Nitroprusside 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • P. Basset
    • 1
  • J. Zwiller
    • 1
  • G. Ulrich
    • 1
  • M. O. Revel
    • 1
  1. 1.Centre de Neurochimie du CNRSStrasbourg CedexFrance

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