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Interaction of Metastatic and Non-Metastatic Tumor Lines with Aortic Endothelial Cell Monolayer and Their Underlying Basal Lamina

  • Volker Schirrmacher
  • Israel Vlodavsky
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

A common and most important route for the dissemination of neoplastic cells within the body involves invasion and penetration of tumor cells into blood vessels and/or lymphatics (1–3). Following penetration of blood vessels, tumor cells are either carried away passively in the blood stream or remain at the site of vessel invasion where they proliferate and continue to shed emboli into the circulation (4). Tumor cells arrested in the capillary beds of different organs must then invade the endothelial cell lining and its underlying basal lamina in order to escape into the extravascular tissue and find a proper microenvironment where they can establish metastasis (1–3). Electron microscopic studies have shown local dissolution of the subendothelial basement membrane at its region of contact with invading tumor cells (5), thereby suggesting an enzymatic mechanism. Of particular significance are recent studies on the degradation of collagen type IV (6,7), fibronectin (8,9), laminin (10), and sulfated proteoglycans (8,9,11) by metastatic tumor cells because these macromolecules are the predominant structural constituents in basement membranes (8,12,13).

Keywords

Heparan Sulfate Vascular Endothelium Basal Lamina Extra Cellular Matrix Metastatic Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Volker Schirrmacher
    • 1
  • Israel Vlodavsky
    • 2
  1. 1.Institut für Immunologie und GenetikDeutsches KrebsforschungszentrumHeidelbergGermany
  2. 2.Department of Clinical OncologyHadassah University HospitalJerusalemIsrael

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