Synergistic Effect of Retinoic Acid on DNA Synthesis of Prostaglandin F Stimulated Swiss 3T3 Cells

  • M. Eschenbruch
  • A. M. Otto
  • L. Jimenez de Asua
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

In confluent resting Swiss mouse 3T3 cells, prostaglandin F (PGF) stimulates the initiation of DNA synthesis and cell division. This effect is enhanced by insulin and reflected by an increase in the rate into S phase (1). Recently it has been demonstrated that PGE1 and PGE2 (at concentrations that do not stimulate DNA synthesis) have a synergistic effect on PGF alone, or with insulin (2). In this communication we report that retinoic acid, as well as analogues of retinoic acid, enhanced the effect of PGF and insulin. This synergy was not further increased by PGE1 or PGE2. Indomethacin, an inhibitor of prostaglandin synthesis, did not affect the synergy of retinoic acid with PGF, indicating that retinoic acid did not extert its effect by increasing prostaglandin synthesis.

Keywords

Toxicity Ethyl DMSO Leukemia Amide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • M. Eschenbruch
    • 1
  • A. M. Otto
    • 1
  • L. Jimenez de Asua
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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