Phylogenetic Information Derived from tRNA Sequence Data

  • M. Sprinzl
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Comparison of 250 sequences of tRNAs revealed that the number of positions available for base replacements and thus the provision of information for phylogenetic evaluation were more limited than is generally assumed. The pattern of natural modification of tRNAs most probably reflects the development of the translation machinery in order to achieve higher precision of protein biosynthesis. It is demonstrated, in several experiments, that the introduction of modi-field nucleosides in tRNA affects the tRNA structure, tRNA: ribosome interaction, and also the fidelity of translation.


tRNA Gene Phylogenetic Information tRNA Sequence Anticodon Loop tRNA Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • M. Sprinzl
    • 1
  1. 1.Lehrstuhl für BiochemieUniversität BayreuthBayreuthGermany

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