Abstract
Arvin is a fibrinogen-cleaving enzyme, a glycoprotein with an average molecular weight of about 38,000. The enzyme catalyzes the hydrolysis of an arginine-glycine link in the α(= “A”, A, Ap or Ay) chain, resulting in liberation of fibrinopeptide A. In contrast to what occurs in the case of thrombin, the β(= B) chain is not affected and no fibrinopeptide B is liberated. When the fibrinopeptide A is split off, des-A-fibrin monomers are formed which can aggregate to long thin filaments. This atypical fibrin is readily dissolved by endogenous plasmin or can be eliminated via the reticuloendothelial system.
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© 1984 Springer-Verlag Berlin Heidelberg
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Goslinga, H. (1984). Lowering the Viscosity by Means of Defibrination with the Aid of Arvin. In: Blood Viscosity and Shock. Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69260-4_5
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DOI: https://doi.org/10.1007/978-3-642-69260-4_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12620-1
Online ISBN: 978-3-642-69260-4
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