Lowering the Viscosity by Means of Defibrination with the Aid of Arvin
Arvin is a fibrinogen-cleaving enzyme, a glycoprotein with an average molecular weight of about 38,000. The enzyme catalyzes the hydrolysis of an arginine-glycine link in the α(= “A”, A, Ap or Ay) chain, resulting in liberation of fibrinopeptide A. In contrast to what occurs in the case of thrombin, the β(= B) chain is not affected and no fibrinopeptide B is liberated. When the fibrinopeptide A is split off, des-A-fibrin monomers are formed which can aggregate to long thin filaments. This atypical fibrin is readily dissolved by endogenous plasmin or can be eliminated via the reticuloendothelial system.
KeywordsHeparin Retina Thrombin Dextran Fibrinogen
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