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Lowering the Viscosity by Means of Defibrination with the Aid of Arvin

  • H. Goslinga
Part of the Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine book series (A+I, volume 160)

Abstract

Arvin is a fibrinogen-cleaving enzyme, a glycoprotein with an average molecular weight of about 38,000. The enzyme catalyzes the hydrolysis of an arginine-glycine link in the α(= “A”, A, Ap or Ay) chain, resulting in liberation of fibrinopeptide A. In contrast to what occurs in the case of thrombin, the β(= B) chain is not affected and no fibrinopeptide B is liberated. When the fibrinopeptide A is split off, des-A-fibrin monomers are formed which can aggregate to long thin filaments. This atypical fibrin is readily dissolved by endogenous plasmin or can be eliminated via the reticuloendothelial system.

Keywords

Deep Vein Thrombosis Fibrinogen Level Chapter Versus Erythrocyte Aggregation Viscosity Lowering 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • H. Goslinga
    • 1
  1. 1.Dept. Anesthesia and Intensive CareSt. Lucas HospitalAmsterdamThe Netherlands

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