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Drug Combinations

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 2))

Abstract

In this chapter discussion is limited to the different types of antimalarial drug combinations that have been described in experimental situations or for clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additive but acting against the same stages and those that are synergistic. All have their place in the control of malaria. While this chapter is written within the context of “Novel Methods of Drug Development”, some of the older drug combinations will be referred to for the sake of completion and as a guide to future developments.

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References

  • Arnold J, Alving AS, Hockwald RS, Clayman CB, Dem RJ, Beutler E, Jeffery GM (1954) The effect of continuous and intermittent primaquine therapy on the relapse rate of Chesson strain vivax malaria. J Lab Clin Med 44:429–438

    PubMed  CAS  Google Scholar 

  • Aviado DM, Brugler B, Bellet J (1968) Pathologic physiology and chemotherapy of Plasmodium berghei V. Suppression of parasitaemia, diuresis and cardiac depression by pteridines. Exp Parasitol 23:294–302

    Google Scholar 

  • Chapman HD (1978) Drug resistance in Coccidia. In: Long PL, Boorman KN, Freeman BM (eds) Avian coccidiosis. British Poultry Science, Edinburgh

    Google Scholar 

  • Cheng CC (1971) Structure and antimalarial activity of aminoalcohols and 2-(p-chlorophenyl)-2-(4-piperidyl) tetrahydrofuran. J Pharm Sci 60:1596–1598

    Article  PubMed  CAS  Google Scholar 

  • Clyde DF (1974) Treatment of drug-resistant malaria in man. Bull WHO 50:243–249

    PubMed  CAS  Google Scholar 

  • Coatney GR, Cooper WC, Young MD, Burgess RW, Smarr RG (1947) Studies in human malaria II. The suppressive action of sulfadiazine and sulfapyrazine against sporozoiteinduced vivax malaria (St. Elizabeth strain ). Am J Hyg 46:105–118

    Google Scholar 

  • Fairley NH (1945) Chemotherapeutic suppression and prophylaxis in malaria. An experimental investigation undertaken by medical research teams in Australia. Trans R Soc Trop Med Hyg 38:311–355

    Article  PubMed  CAS  Google Scholar 

  • Ferone R (1977) Folate metabolism in malaria. Bull WHO 55:291–298

    PubMed  CAS  Google Scholar 

  • Ferone R, Burchall JJ, Hitchings GH (1969) P. berghei dihydrofolate reductase. Isolation, properties and inhibition by antifolates. Mol. Pharmacol 5:49–59

    Google Scholar 

  • Friedkin M, Crawford EJ, Plante LT (1971) Empirical vs rational approaches in chemotherapy. Ann NY Acad Sci 186:209–213

    Article  PubMed  CAS  Google Scholar 

  • Genther CS, Smith CC (1977) Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. J Med Chem 20:237–243

    Article  PubMed  CAS  Google Scholar 

  • Gero AM, O’Sullivan WJ (1979) Studies on dihydroorotate dehydrogenase from human spleen and the malarial parasite, Plasmodium berghei. Proc Aust Biochem Soc 12:9

    Google Scholar 

  • Greenberg J, Boyd BL, Josephson ES (1948) Synergistic effect of chlorguanide and sulfadiazine against Plasmodium gallinaceum in the chick. J Pharmacol Exp Ther 94:60–64

    PubMed  CAS  Google Scholar 

  • Gutteridge WE, Coombs GH (1977) Biochemistry of parasitic protozoa. Macmillan, London

    Google Scholar 

  • Hall AP (1977) Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria. Br Med J 1:1626–1628

    Article  PubMed  CAS  Google Scholar 

  • Howells RE, Peters W, Homewood CA (1972) Physiological adaptability of malaria parasites. In: Van den Bossche H (ed) Comparative biochemistry of parasites. Academic, New York, pp 235–258

    Google Scholar 

  • Hunsicker LG, Schwarz RA, Barnwell FM (1967) Malaria from Vietnam. Ann Intern Med 66:1046

    Google Scholar 

  • Jaffe J (1980) Filarial folate-related metabolism as a potential target for selective inhibitors. In: Van den Bossche J (ed) The host-invader interplay. Elsevier-North Holland, Amsterdam, pp 219–234

    Google Scholar 

  • Joyner LP, Norton CC (1978) The activity of methyl benzoquate and clopidol against Eimeria maxima:synergy and drug resistance. Parasitology 76:369–377

    Article  PubMed  CAS  Google Scholar 

  • Kaddu JB, Warhurst DC, Peters W (1974) The chemotherapy of rodent malaria, XIX. The action of a tetracycline derivative, minocycline, on drug-resistant Plasmodium berghei. Ann Trop Med Parasitol 68:41–46

    PubMed  CAS  Google Scholar 

  • Kinnamon KE, Davidson DE (1980) Plasmodium berghei:folic acid antagonist combinations for treatment of malaria in rhesus monkeys. Exp Parasitol 49:277–280

    Google Scholar 

  • Kinnamon KE, Ager AL, Orchard RW (1976) Plasmodium berghei:combining folic acid antagonists for potentiation against malaria infections in mice. Exp Parasitol 40:95–102

    Google Scholar 

  • Kisliuk RL, Friedkin M, Schmidt LH, Rossan RN (1967) Antimalarial activity of tetrahydrohomopteroic acid. Science 156:1616–1617

    Article  PubMed  CAS  Google Scholar 

  • O’Sullivan WJ, Ketley K (1980) Biosynthesis of uridine monophosphate in Plasmodium berghei. Ann Trop Med Parasitol 74:109–114

    PubMed  Google Scholar 

  • Pearlman EJ, Lampe RM, Thiemanun W, Kennedy RS (1977) Chemosuppressive field trials in Thailand. III. The suppression of Plasmodium falciparum and Plasmodium vivax parasitaemias by a sulfadoxine-pyrimethamine combination. Am J Trop Hyg 26:1108–1115

    CAS  Google Scholar 

  • Peters W (1970a) Chemotherapy and drug resistance in malaria. Academic, London

    Google Scholar 

  • Peters W (1970b) A new type of antimalarial drug potentiation. Trans R Soc Trop Med Hyg 64:462–464

    Article  PubMed  CAS  Google Scholar 

  • Peters W (1970c) The chemotherapy of rodent malaria, XII. Substituted tetrahydrofurans, a new chemical family of antimalarials. The action of 2-(p-chlorophenyl)-2-(4-piperidy1)-tetrahydrofuran against Plasmodium berghei and Plasmodium chabaudi. Ann Trop Med Parasitol 64:189–202

    PubMed  CAS  Google Scholar 

  • Peters W, Portus JH, Robinson BL (1973) The chemotherapy of rodent malaria, XVII. Dynamics of drug resistance, part 3:influence of drug combinations on the development of resistance to chloroquine in P. berghei. Ann Trop Med Parasitol 67:143–154

    PubMed  CAS  Google Scholar 

  • Peters W, Davies EE, Robinson BL (1975) The chemotherapy of rodent malaria, XXIII. Causal prophylaxis, part II:practical experience with Plasmodium yoelii nigeriensis in drug screening. Ann Trop Med Parasitol 69:311–328

    PubMed  CAS  Google Scholar 

  • Peters W, Howells RE, Portus J, Robinson BL, Thomas S, Warhurst DC (1977) The chemotherapy of rodent malaria, XXVII. Studies on mefloquine (WR 142,490). Ann Trop Med Parasitol 71:407–418

    PubMed  CAS  Google Scholar 

  • Powers KG, Jacobs RL, Good WC, Koontz LC (1969) Plasmodium vinckei:Production of chloroquine-resistant strain. Exp Parasitol 26:193–202

    Google Scholar 

  • Rabinovich SA (1965) Experimental investigations of antimalarial drug Haloquine. III. Investigation of the possibility to restrain the development of chemoresistance to chloridine (Daraprim) by combined administration of chloridine with Haloquine. Med Parazitol (Mosk) 34:434–439

    CAS  Google Scholar 

  • Raether W, Fink E (1979) Antimalarial activity of floxacrine (HOE 991). I. Studies on blood schizontocidal action of floxacrine against Plasmodium berghei, P. vinckei and P. cynomolgi. Ann Trop Med Parasitol 73:505–526

    PubMed  CAS  Google Scholar 

  • Rieckmann KH, McNamara JV, Frischer H, Stockert TA, Carson PE, Powell RD (1968) Gametocytocidal and sporontocidal effects of primaquine and sulfadiazine with pyrimethamine in a chloroquine-resistant strain of P. falciparum. Bull WHO 38:625–632

    PubMed  CAS  Google Scholar 

  • Rollo IM (1955) The mode of action of sulphonamides, proguanil and pyrimethamine on Plasmodium gallinaceum. Br J Pharmacol Chemother 10:208–224

    PubMed  CAS  Google Scholar 

  • Rosario VE (1976) Genetics of chloroquine-resistance in malaria parasites. Nature 261:585–586

    Article  PubMed  CAS  Google Scholar 

  • Ryley JF, Betts MJ (1973) Chemotherapy of chicken coccidiosis. Adv Pharmacol Chemother 11:221–293

    Article  PubMed  CAS  Google Scholar 

  • Ryley JF, Peters W (1970) The antimalarial activity of some quinolone esters. Ann Trop Med Parasitol 64:209–222

    PubMed  CAS  Google Scholar 

  • Schmidt LD (1979a) Studies on the 2,4-diamino-6-substituted quinazolines. III. The capacity of sulfadiazine to enhance the activities of WR-158,122 and WR-159,412 against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys. Am J Trop Med Hyg 28:808–818

    PubMed  CAS  Google Scholar 

  • Schmidt LD (1979b) Antimalarial properties of floxacrine, a dihydroacridinedione derivative. Antimicrob Agents Chemother 16:475–485

    PubMed  CAS  Google Scholar 

  • Schmidt LH, Harrison J, Rossan RN, Vaughan D, Crosby R (1977) Quantitative aspects of pyrimethamine-sulfonamide synergism. Am J Trop Med Hyg 26:837–848

    PubMed  CAS  Google Scholar 

  • Sherman IW (1979) Biochemistry of Plasmodium (malarial parasites). Microbiol Rev 43:453–495

    PubMed  CAS  Google Scholar 

  • Tigertt WD (1966) Present and potential malaria problem. Milit Med [Suppl] 131:853–856

    Google Scholar 

  • Vivona S, Brewer GJ, Conrad M, Alving AS (1961) The concurrent weekly administration of chloroquine and primaquine for the prevention of Korean vivax malaria. Bull WHO 25:267–269

    PubMed  CAS  Google Scholar 

  • Warhurst DC (1977) Chloroquine-erythromycin potentiation of P. berghei. Ann Trop Med Parasitol 71:383

    PubMed  CAS  Google Scholar 

  • Warhurst DC, Robinson BL, Peters W (1976) The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei. Ann Trop Med Parasitol 70:253–258

    PubMed  CAS  Google Scholar 

  • Wilkinson RN, Noeypatimanondh S, Gould DJ (1976) Infectivity of falciparum patients for anopheline mosquitoes before and after chloroquine treatment. Trans R Soc Trop Med Hyg 70:306–307

    Article  PubMed  CAS  Google Scholar 

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© 1984 Springer-Verlag Berlin Heidelberg

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Peters, W. (1984). Drug Combinations. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drug II. Handbook of Experimental Pharmacology, vol 68 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69254-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-69254-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69256-7

  • Online ISBN: 978-3-642-69254-3

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