Drug Combinations

  • W. Peters
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 68 / 2)


In this chapter discussion is limited to the different types of antimalarial drug combinations that have been described in experimental situations or for clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additive but acting against the same stages and those that are synergistic. All have their place in the control of malaria. While this chapter is written within the context of “Novel Methods of Drug Development”, some of the older drug combinations will be referred to for the sake of completion and as a guide to future developments.


Vivax Malaria Antimalarial Activity Plasmodium Berghei Rodent Malaria Folate Pathway 
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© Springer-Verlag Berlin Heidelberg 1984

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  • W. Peters

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