Skip to main content
SpringerLink
Log in

Application of HPLC to the Analysis of Natural and Synthetic Pharmaceutically Important Drugs

  • Chapter
Practice of High Performance Liquid Chromatography

Part of the book series: Chemical Laboratory Practice ((CHEMICAL LABORA))

  • 910 Accesses

Abstract

More than fifteen years after the introduction of HPLC into pharmaceutical analysis, a comprehensive literature survey is still lacking, and no systematic scheme of analysis has been published. Even within the scope of this handbook, only a sample of the relevant literature can be discussed, based on some especially important pharmaceuticals and classes of compounds. In view of the large number of pharmaceuticals commercially available today, this selective treatment is clearly unavoidable. Thus, the register of preparations of the German pharmaceutical industry, known as the “red list”, embraces 86 areas of indication, and contains over 8900 products in more than 1100 formulations. Excluding polymeric substances, about 80% of these pharmaceuticals are suitable for separation and purification by HPLC; this provides some indication of the present and future potential of HPLC in pharmaceutical analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

C:

Column

F:

Flow rate

T:

Column temperature

Mph:

Mobile phase

References

  1. Tank, F.W.: Dissertation Uni Marburg (1976)

    Google Scholar 

  2. Daltrup, T., Susanto, F., Michalke, P.: Fresenius Z. Anal. Chem. 308, 413 (1981)

    Article  Google Scholar 

  3. Rehm, K.D., Steinigen, M.: Pharm. Ztg. 126, 99 (1981)

    CAS  Google Scholar 

  4. Bailey, F.: J. Chromatogr. 122, 73 (1976)

    Article  CAS  Google Scholar 

  5. Westerlund, D., Pettersson, B., Carlquist, J.: J. Pharm. Sc. 71, 1148 (1982)

    Article  CAS  Google Scholar 

  6. Larsen, C., Bundgaard, H.: J. Chromatogr. 147, 143 (1978)

    Article  CAS  Google Scholar 

  7. Lebelle, M.J., Wilson, W.L., Lauriault, G.: J. Chromatogr. 202, 144 (1980)

    Article  CAS  Google Scholar 

  8. Sakai, T.T., Riodan, J.M.: J. Chromatogr. 178, 302 (1979)

    Article  CAS  Google Scholar 

  9. Rzeszotarski, W.J., Eckelman, W.C., Reba, R.C.: J. Chromatogr. 124, 88 (1976)

    Article  CAS  Google Scholar 

  10. Saki, T.T.: J. Chromatogr. 161, 389 (1978)

    Article  Google Scholar 

  11. Hansen, S.H., Thomsen, M.: J. Chromatogr. 123, 205 (1976)

    Article  CAS  Google Scholar 

  12. Crombez, E., Bossche, W. van den, Moerloose P. de: J. Chromatogr. 169, 343 (1979)

    Article  CAS  Google Scholar 

  13. Young, M.G.: J. Chromatogr. 150, 221 (1978)

    Article  CAS  Google Scholar 

  14. Ali, S.L.: J. Chromatogr. 154, 103 (1978)

    Article  CAS  Google Scholar 

  15. Le Belle, M.J., Young, D.C., Graham, K.C., Wilson, W.L.: J. Chromatogr. 170, 282 (1979)

    Article  Google Scholar 

  16. Vigh, Gy., Inczedy, J.: J. Chromatogr. 129, 81 (1976)

    Article  CAS  Google Scholar 

  17. Granneman, G.R., Senello, L.T.: J. Pharm. Sc. 71, 1112 (1982)

    Article  CAS  Google Scholar 

  18. Tsuji, K., Goetz, J.F.: J. Chromatogr. 147, 359 (1978)

    Article  CAS  Google Scholar 

  19. Tsuji, K., Goetz, J.F.: J. Chromatogr. 157, 185 (1978)

    Article  CAS  Google Scholar 

  20. Koch, W.L.: Analytical profiles of Drug substances, 8, 159 (1979)

    CAS  Google Scholar 

  21. Tsuji, K., Kane, M.O.: J. Pharm. Sc. 71, 1160 (1982)

    Article  CAS  Google Scholar 

  22. Anhalt, J.P., Sancilio, F.D., Corcle, T.Mc: J. Chromatogr. 153, 489 (1978)

    CAS  Google Scholar 

  23. Axelsen, K.S., Vogelsang, S.H.: J. Chromatogr. 140, 174 (1977)

    Article  CAS  Google Scholar 

  24. Mays, D.L., Apeldoorn, R.J. van, Lauback, R.G.: J. Chromatogr. 120, 93 (1976)

    Article  CAS  Google Scholar 

  25. Kondo, K.: J. Chromatogr. 169, 329 (1979)

    Article  CAS  Google Scholar 

  26. Hagel, R.B., Waysek, E.H., Hemphrey, D.: J. Chromatogr. 170, 391 (1979)

    Article  CAS  Google Scholar 

  27. Srivastava, S.C., Hornemann, U.: J. Chromatogr. 161, 393 (1978)

    Article  CAS  Google Scholar 

  28. Sorel, R.H., Roseboom, H.: J. Chromatogr. Biomedical appl. 162, 461 (1979)

    Article  CAS  Google Scholar 

  29. Grubb, P.E.: Analytical Profiles of drug substances, 8, 371 (1979)

    CAS  Google Scholar 

  30. Tsuji, K., Goetz, J.F., Meter, W. Van, Gusciora, K.A.: J. Chromatogr. 175, 141 (1979)

    Article  CAS  Google Scholar 

  31. Vadino, W.A., Sugita, E.T., Schnaare, R.L., Ando, M.Y., Niebegall, P.J.: J. Pharm. Sc. 68, 1316 (1979)

    Article  CAS  Google Scholar 

  32. Lebelle, M., Graham, K., Wilson, W.L.: J. Pharm. Sc. 68, 555 (1979)

    Article  CAS  Google Scholar 

  33. Westerlund, D., Carlquist, J., Theodorsen, A.: Act. Pharm. Suec. 16, 187 (1979)

    CAS  Google Scholar 

  34. Nachtmann, F.: Chromatographia, 12, 380 (1979)

    Article  CAS  Google Scholar 

  35. Kalasz, H., Horvath, C.: J. Chromatogr. 215, 295 (1981)

    Article  CAS  Google Scholar 

  36. Vlasakova, U., Benes, J., Zivny, K.: J. Chromatogr. 151, 199 (1978)

    Article  CAS  Google Scholar 

  37. Mourot, D., Delepine, B., Boisseau, J., Gayot, G.: J. Chromatogr. 161, 386 (1978)

    Article  CAS  Google Scholar 

  38. Whall, T.J.: J. Chromatogr. 219, 89 (1981)

    Article  CAS  Google Scholar 

  39. Oles, P.J.: J. Pharm. Sc. 67, 1300 (1978)

    Article  CAS  Google Scholar 

  40. Tsuji, K., Roberson, J.: J. Pharm. Sc. 65, 400 (1976)

    Article  CAS  Google Scholar 

  41. Mack, G.D., Ashworth, R.B.: J. Chromatogr. Sc. 16, 93 (1978)

    CAS  Google Scholar 

  42. Know, J.H., Jurand, J.: J. Chromatogr. 186, 763 (1979)

    Article  Google Scholar 

  43. Lindauer, R.F., Cohen, D.M., Munelly, K.P.: Anal. Chem. 48, 1731 (1976)

    Article  CAS  Google Scholar 

  44. Mourot, D., Delepine, B., Boisseau, J., Gayot, G.: J. Chromatogr. 190, 486 (1980)

    Article  CAS  Google Scholar 

  45. Eksborg, St.: J. Chromatogr. 208, 78 (1981)

    Article  CAS  Google Scholar 

  46. Nelis, H.J.C.F., Leenheer, A.P. De: J. Chromatogr. 195, 35 (1980)

    Article  CAS  Google Scholar 

  47. Kwan, R.H., MacLeod, S.M., Spino, M., Teare, F.W.: J. Pharm. Sc. 71, 1118 (1982)

    Article  CAS  Google Scholar 

  48. Kirchmeier, R.L., Upton, R.P.: Anal. Chem. 50, 349 (1978)

    Article  CAS  Google Scholar 

  49. Barth, H.G., Conner, A.Z.: J. Chromatogr. 131, 375 (1977)

    Article  CAS  Google Scholar 

  50. Mangia, A., Silingardi, S., Bortesi, F., Grisanti, G., Bitetto, M. Di: J. Pharm. Sc. 68, 652 (1979)

    Article  CAS  Google Scholar 

  51. Brown, L.W.: J. Pharm. Sc. 67, 669 (1978)

    Article  CAS  Google Scholar 

  52. Schwarzenbach, R.: J. Chromatogr. 251, 339 (1982)

    Article  CAS  Google Scholar 

  53. Albanbauer, J., Fehn, J., Furtner, W., Megges, G.: Arch. f. Krim. 162, 103 (1978)

    CAS  Google Scholar 

  54. Megges, G.: Arch. f. Krim. 164, 25 (1979)

    CAS  Google Scholar 

  55. Einhellig, K., Kraatz, A., Megges, G.: Arch. f. Krim. 166, 99 (1980)

    CAS  Google Scholar 

  56. Jane, I., Scott, A., Sharpe, L.W.R., White, P.C.: J. Chromatogr. 214, 243 (1981)

    Article  CAS  Google Scholar 

  57. Detaevernier, M.R., Dryon, L., Massart, D.L.: J. Chromatogr. 128, 204 (1976)

    Article  CAS  Google Scholar 

  58. Wheals, B.B.: J. Chromatogr. 177, 263 (1979)

    Article  CAS  Google Scholar 

  59. Lund, W., Hannisdal, M., Greibrook, T.: J. Chromatogr. 173, 249 (1979)

    Article  CAS  Google Scholar 

  60. King, L.A.: J. Chromatogr. 208, 113 (1981)

    Article  CAS  Google Scholar 

  61. Wahlund, K.-G., Sokolowski, A.: J. Chromatogr. 151, 299 (1978)

    Article  CAS  Google Scholar 

  62. Wan Po, A. Li, Irwin, W.J.: J. Pharm. Pharmakol. 31, 512 (1979)

    Google Scholar 

  63. Sokolowski, A., Wahlund, K.-G.: J. Chromatogr. 189, 299 (1980)

    Article  CAS  Google Scholar 

  64. Harzer, K., Barchet, R.: J. Chromatogr. 132, 83 (1977)

    Article  CAS  Google Scholar 

  65. Vilon, C., Vercruysse, A.: J. Chromatogr. 189, 94 (1980)

    Article  Google Scholar 

  66. Riedmann, M., Hewlett-Packard: Application note AN 232–2 (1977)

    Google Scholar 

  67. Siggia, S., Dishman, R.A.: Anal. Chem. 42, 1233 (1970)

    Google Scholar 

  68. Görög, S.: Fresenius Z. Anal. Chem. 309, 97 (1981)

    Article  Google Scholar 

  69. Kingston, D.G.I.: Lloydia 42, 237 (1979)

    CAS  Google Scholar 

  70. Heftmann, E., Hunter, J.R.: J. Chromatogr. 165, 283 (1979)

    Article  CAS  Google Scholar 

  71. Rehm, K.D., Steinigen, M.: Pharm. Ztg. 127, 888 (1982)

    CAS  Google Scholar 

  72. Lin, J.-T., Heftmann, E.: J. Chromatogr. 212, 239 (1981)

    Article  CAS  Google Scholar 

  73. Walters, M.J., Dunbar, W.E.: J. Pharm. Sc. 71, 446 (1982)

    Article  CAS  Google Scholar 

  74. Ballerini, R., Chinol, M., Ghelardoni, M.: J. Chromatogr. 193, 413 (1980)

    Article  CAS  Google Scholar 

  75. Hunter, I.R., Waiden, M.K., Heftmann, E.: J. Chromatogr. 176, 485 (1979)

    Article  CAS  Google Scholar 

  76. Capitano, G., Tscherne, R.: J. Pharm. Sc. 68, 311 (1979)

    Article  CAS  Google Scholar 

  77. Johnston, M.A.: J. Chromatogr. 216, 269 (1981)

    Article  CAS  Google Scholar 

  78. Hermansson, J.: J. Chromatogr. 194, 80 (1980)

    Article  CAS  Google Scholar 

  79. Hermansson, J.: J. Chromatogr. 152, 437 (1978)

    Article  CAS  Google Scholar 

  80. Hara, S., Hayashi, S.: J. Chromatogr. 142, 689 (1977)

    Article  CAS  Google Scholar 

  81. Tittel, G., Habermeier, H., Wagner, H.: Planta med. 45, 207 (1982)

    Article  CAS  Google Scholar 

  82. Su, S.C., Hartkopf, A.V., Karger, B.L.: J. Chromatogr. 119, 523 (1976)

    Article  CAS  Google Scholar 

  83. Johansson, I.M., Wahlund, K.-G.: Acta Pharm. Suec. 14, 459 (1977)

    CAS  Google Scholar 

  84. Jennings, E.C., Landgraf, W.C.: J. Pharm. Sc. 66, 1784 (1977)

    Article  CAS  Google Scholar 

  85. Umagat, H., McGarry, P.F., Tscherne, R.J.: J. Pharm. Sc. 68, 922 (1979)

    Article  CAS  Google Scholar 

  86. Rotsch, T.D., Sydor, R.J., Pietrzyk, D.J.: J. Chromatogr. Sc. 17, 339 (1979)

    Article  CAS  Google Scholar 

  87. Singletary, R.O., Sancillio, F.D.: J. Pharm. Sc. 69, 144 (1980)

    Article  CAS  Google Scholar 

  88. Hermansson, J.: Chromatographia 13, 741 (1980)

    Article  CAS  Google Scholar 

  89. Wessely, K., Zech, K.: HPLC in pharmaceutical analysis Firmenschrift Hewlett Packard

    Google Scholar 

  90. Gilpin, R.K.: Anal. Chem. 51, 257R (1979)

    Google Scholar 

  91. Gilpin, R.K., Pachala, L.A., Ranweiler, J.S.: Anal. Chem. 53, 142R (1981)

    Google Scholar 

  92. Taylor, R.F., Gaudio, L.A.: J. Chromatogr. 187, 212 (1980)

    Article  CAS  Google Scholar 

  93. Gupta, V. Das, Sachanandani, S.: J. Pharm. Sc. 66, 897 (1977)

    Article  CAS  Google Scholar 

  94. Eiden, F., Greske, K.: Dtsch. Apoth. Ztg. 123, 958 (1983)

    CAS  Google Scholar 

  95. Greske, K.: Dissertation Uni München (1982)

    Google Scholar 

  96. Gupta, V. Das: J. Pharm. Sc. 66, 110 (1977)

    Article  CAS  Google Scholar 

  97. Bartlett, J.M., Segelman, A.B.: J. Chromatogr. 255, 239 (1983)

    Article  CAS  Google Scholar 

  98. Mannan, C.A., Krol, G.J., Kho, B.T.: J. Pharm. Sc. 66, 1618 (1977)

    Article  CAS  Google Scholar 

  99. Fu, C., Sibley, M.J.: J. Pharm. Sc. 66, 425 (1977)

    Article  CAS  Google Scholar 

  100. Steward, J.T., Honigberg, I.L., Brant, J.P., Murray, W.A., Webb, J.L., Smith, J.B.: J. Pharm. Sc. 65, 1536 (1976)

    Article  Google Scholar 

  101. Bailey, L.C., Abdou, H.: J. Pharm. Sc. 66, 564 (1977)

    Article  CAS  Google Scholar 

  102. Butterfield, A.G., Lovering, E.G., Sears, R.W.: J. Pharm. Sc. 9, 222 (1980)

    Article  Google Scholar 

  103. Fischer, L.J., Thies, R.L., Charkowski, D.: Anal. Chem. 50, 2143 (1978)

    Article  CAS  Google Scholar 

  104. Leung, C.P.: J. Chromatogr. 178, 178 (1979)

    Article  Google Scholar 

  105. Jansson, S.O., Andersson, J., Persson, B.E.: J. Chromatogr. 203, 93 (1981)

    Article  CAS  Google Scholar 

  106. Pettersson, C., Schill, G.: J. Chromatogr. 204, 179 (1981)

    Article  CAS  Google Scholar 

  107. Wildanger, W.: Dtsch. Lebensm. Rundschau 72, 160 (1976)

    CAS  Google Scholar 

  108. Firmenschrift Perkin-Elmer Nr. 102 (1979)

    Google Scholar 

  109. Frei, R.W., Santi, W., Thomas, M.: J. Chromatogr. 116, 365 (1976)

    Article  CAS  Google Scholar 

  110. Nachtmann, F.: Z. Anal. Chem. 282, 209 (1976)

    Article  CAS  Google Scholar 

  111. Nachtmann, F., Spitzy, H., Frei, R.W.: J. Chromatogr. 122, 293 (1976)

    Article  CAS  Google Scholar 

  112. Gfeller, J.C., Frey, G., Frei, R.W.: J. Chromatogr. 142, 271 (1977)

    Article  CAS  Google Scholar 

  113. Aigner, R., Spitzy, H., Frei, R.W.: J. Chromatogr. Sc. 14, 381 (1976)

    CAS  Google Scholar 

  114. Tscherne, R.J., Capitano, G.: J. Chromatogr. 136, 337 (1977)

    Article  CAS  Google Scholar 

  115. Collet, G., Rocca, J.L., Sage, D., Beriticat, P.: J. Chromatogr. 121, 213 (1976)

    Article  CAS  Google Scholar 

  116. Kessler, M.J.: J. Chromatogr. Sc. 20, 523 (1982)

    CAS  Google Scholar 

  117. Wal, Sj. Van der, Snyder, L.R.: J. Chromatogr. 255, 463 (1983)

    Article  Google Scholar 

  118. Harzer, K., Barchet, R.: Dtsch. Apoth. Ztg. 116, 1229 (1976)

    CAS  Google Scholar 

  119. Halstead, G.W.: J. Pharm. Sc. 71, 1108 (1982)

    Article  CAS  Google Scholar 

  120. Gupta, V. Das, Ghanekar, A.G.: J. Pharm. Sc. 66, 895 (1977)

    Article  CAS  Google Scholar 

  121. Honigberg, J.L., Stewart, J.T., Smith, M.: J. Pharm. Sc. 67, 675 (1978)

    Article  CAS  Google Scholar 

  122. Stewart, J.T., Honigberg, J.L., Coldren, J.W.: J. Pharm. Sc. 68, 32 (1979)

    Article  CAS  Google Scholar 

  123. Gimet, R., Filloux, A.: J. Chromatogr. 177, 333 (1979)

    Article  CAS  Google Scholar 

  124. Brown, N.B., Sleeman, H.K.: J. Chromatogr. 150, 225 (1978)

    Article  CAS  Google Scholar 

  125. Stömbom, J., Bruhn, J.G.: J. Chromatogr. 147, 513 (1978)

    Article  Google Scholar 

  126. Smith, R.N.: J. Chromatogr. 115, 101 (1975)

    Article  CAS  Google Scholar 

  127. Smith, R.N., Vaughan, C.G.: J. Chromatogr. 129, 347 (1976)

    Article  CAS  Google Scholar 

  128. Flora, K.P., Cradock, J.C., Davignon, J.P.: J. Chromatogr. 206, 117 (1981)

    Article  CAS  Google Scholar 

  129. Görög, S., Herenyi, B., Javanovics, K.: J. Chromatogr. 139, 203 (1977)

    Article  Google Scholar 

  130. Kohl, W., Witte, B., Höfle, G.: Planta med. 47, 177 (1983)

    Article  CAS  Google Scholar 

  131. Szepesi, G., Gazdag, M.: J. Chromatogr. 205, 57 (1981)

    Article  CAS  Google Scholar 

  132. Szepesi, G., Gazdag, M.: J. Chromatogr. 204, 341 (1981)

    Article  CAS  Google Scholar 

  133. Maeden, F.P.B. van der, Rens, P.T. van, Buytenhuys, F.A., Buurmann, E.: J. Chromatogr. 142, 715 (1977)

    Article  Google Scholar 

  134. Verzele, M., Taeye, L. de, Dyck, J. van, Decker, G. de: J. Chromatogr. 214, 95 (1981)

    Article  CAS  Google Scholar 

  135. Forni, G., Massarani, G.: J. Chromatogr. 131, 444 (1977)

    Article  CAS  Google Scholar 

  136. Klein, A.E., Davis, P.J.: J. Chromatogr. 207, 247 (1981)

    Article  CAS  Google Scholar 

  137. Ahmed, M.S., Fong, H.H.S., Soejarto, D.D., Dobberstein, R.H., Waller, D.P., Moreno-Azorero, R.: J. Chromatogr. 213, 340 (1981)

    Article  CAS  Google Scholar 

  138. Nobuhara, Y., Hirano, S., Namba, K., Hashimoto, M.: J. Chromatogr. 190, 251 (1980)

    Article  CAS  Google Scholar 

  139. Wu, C.Y., Wittick, J.J.: Anal. Chem. 49, 359 (1977)

    Article  CAS  Google Scholar 

  140. Olieman, C., Maat, L., Waliszewski, K., Beyerman, H.C.: J. Chromatogr. 133, 382 (1977)

    Article  CAS  Google Scholar 

  141. Hansen, St.H.: J. Chromatogr. 212, 229 (1981)

    Article  CAS  Google Scholar 

  142. Sasse, F., Hammer, J., Berlin, J.: J. Chromatogr. 194, 234 (1980)

    Article  CAS  Google Scholar 

  143. Niwa, H., Ishiwata, H., Yamade, K.: J. Chromatogr. 257, 146 (1983)

    Article  CAS  Google Scholar 

  144. Quails, C.W. jr., Segall, H.J.: J. Chromatogr. 150, 202 (1978)

    Article  Google Scholar 

  145. Ramsdell, H.S., Buhler, D.R.: J. Chromatogr. 210, 154 (1981)

    Article  CAS  Google Scholar 

  146. Huizing, H.J., Boer, F. De, Malingre, Th.M.: J. Chromatogr. 214, 257 (1981)

    Article  CAS  Google Scholar 

  147. Tittel, G., Hinz, H., Wagner, H.: Planta med. 37, 1 (1979)

    Article  CAS  Google Scholar 

  148. Wagner, H., Neidhardt, U., Tittel, G.: Planta med. 41, 232 (1981)

    Article  CAS  Google Scholar 

  149. Neidhardt, U.: Dissertation Uni München (1982)

    Google Scholar 

  150. Wurst, M., Flieger, M., Rekacek, Z.: J. Chromatogr. 150, 477 (1978)

    Article  CAS  Google Scholar 

  151. Szepesy, L., Feher, J., Szepesi, G., Gazdag, M.: J. Chromatogr. 149, 271 (1978)

    Article  CAS  Google Scholar 

  152. Yoshida, A., Yamazaki, S., Sakai, T.: J. Chromatogr. 170, 399 (1979)

    Article  CAS  Google Scholar 

  153. Bethke, H., Delz, B., Stick, K.: J. Chromatogr. 123, 193 (1976)

    Article  CAS  Google Scholar 

  154. Flieger, M., Wurst, M., Stuchlik, J., Rekacek, Z.: J. Chromatogr. 207, 139 (1981)

    Article  CAS  Google Scholar 

  155. Szepesi, G., Gazdag, M., Terdy, L.: J. Chromatogr. 191, 101 (1980)

    Article  CAS  Google Scholar 

  156. Dolinar, J.: Chromatographia 10, 364 (1977)

    Article  CAS  Google Scholar 

  157. Wurst, M., Flieger, M., Rekacek, Z.: J. Chromatogr. 174, 401 (1979)

    Article  CAS  Google Scholar 

  158. Verpoorte, R., Kodde, E.W., Bearheim, A. — Svendsen, Planta med. 34, 62 (1978)

    Article  CAS  Google Scholar 

  159. Verpoorte, R., Bearheim-Svendsen, A.: J. Chromatogr. 109, 441 (1975)

    Article  CAS  Google Scholar 

  160. Kingston, D.G.I.: Lloydia, 42, 237 (1979)

    CAS  Google Scholar 

  161. Verpoorte, R., Bearheim-Svendsen, A.: J. Chromatogr. 120, 203 (1976)

    Article  CAS  Google Scholar 

  162. Urbanyi, Ti., Piedmont, A., Willis, E., Manning, G.: J. Pharm. Sc. 65, 257 (1976)

    Article  CAS  Google Scholar 

  163. Weber, J.D.: J. AOAC, 59, 1409 (1976)

    CAS  Google Scholar 

  164. Noordam, A., Wasliewski, W., Olieman, C, Maat, L., Beyerman, H.C.: J. Chromatogr. 153, 271 (1978)

    Article  CAS  Google Scholar 

  165. Kennedy, J.M., McNamara, P.E.: J. Chromatogr. 212, 331 (1981)

    Article  CAS  Google Scholar 

  166. Sticher, O., Meier, B.: Pharm. Act. Helv. 53, 40 (1978)

    CAS  Google Scholar 

  167. Verzele, M., Potter, M. De: J. Chromatogr. 166, 320 (1978)

    Article  CAS  Google Scholar 

  168. Johnson, E.L., Gloor, R., Majors, R.E.: J. Chromatogr. 149, 571 (1978)

    Article  CAS  Google Scholar 

  169. Fisher, J.F.: J. Agric. Food. Chem. 26, 497 (1978)

    Article  CAS  Google Scholar 

  170. Nestler, Th., Tittel, G., Wagner, H.: Planta med. 38, 204 (1980)

    Article  CAS  Google Scholar 

  171. Evans, F.J.: J. Chromatogr. 88, 411 (1974)

    Article  CAS  Google Scholar 

  172. Firmenschriften Merck (1976)

    Google Scholar 

  173. Castle, M.C.: J. Chromatogr. 115, 437 (1975)

    Article  CAS  Google Scholar 

  174. Lindner, W., Frei, R.W.: J. Chromatogr. 117, 81 (1976)

    Article  CAS  Google Scholar 

  175. Cobb, P.H.: Analyst, 101, 768 (1976)

    Article  CAS  Google Scholar 

  176. Erni, F., Frei, R.W.: J. Chromatogr. 130, 169 (1977)

    Article  CAS  Google Scholar 

  177. Rehm, K.D., Steinigen, M.: Pharm. Ztg. 127, 443 (1982)

    CAS  Google Scholar 

  178. Gfeller, J.C., Frei, G., Erni, R.W.: J. Chromatogr. 142, 271 (1977)

    Article  CAS  Google Scholar 

  179. Fujii, Y., Fukuda, H., Saito, Y., Yamazaki, M.: J. Chromatogr. 202, 139 (1980)

    Article  CAS  Google Scholar 

  180. Shimada et al.: J. Chromatogr. 124, 79 (1976)

    Article  CAS  Google Scholar 

  181. Shimada et al.: Chem. Pharm. Bull. 24, 2995 (1976)

    CAS  Google Scholar 

  182. Tittel, G., Wagner, H.: Planta med. 39, 125 (1980)

    Article  CAS  Google Scholar 

  183. Jurenitsch, J. et al.: Planta med. 39, 272 (1980)

    Google Scholar 

  184. Davydov, V.Ya., Gonzalez, E., Kiselev, A.V.: J. Chromatogr. 204, 293 (1981)

    Article  CAS  Google Scholar 

  185. Tittel, G., Wagner, H.: Planta med. 43, 257 (1981)

    Article  Google Scholar 

  186. Wichtl, M., Mangkudidjojo, M., Wichtl-Bleier, W.: J. Chromatogr. 234, 503 (1981)

    Article  Google Scholar 

  187. Tittel, G., Habermeier, H., Wagner, H.: Planta med. 45, 207 (1982)

    Article  CAS  Google Scholar 

  188. Wichtl, M., Wichtl-Bleier, W., Mangkudidjojo, M.: J. Chromatogr. 247, 359 (1982)

    Article  CAS  Google Scholar 

  189. Desta, B., Kwang, E., McErlane, K.M.: J. Chromatogr. 240, 137 (1982)

    Article  CAS  Google Scholar 

  190. Jurenitsch, J., Kapp, B., Bamberg-Kubelka, E., Kern, R., Kubelka, W.: J. Chromatogr. 240, 125 (1982)

    Article  CAS  Google Scholar 

  191. Jurenitsch, J., Kapp, B., Bamberg-Kubelka, E., Kern, R., Kubelka, W.: J. Chromatogr. 240, 235 (1982)

    Article  CAS  Google Scholar 

  192. Wu, F.F., Dobberstein, R.H.: J. Chromatogr. 140, 65 (1977)

    Article  CAS  Google Scholar 

  193. Enson, J.M., Seiber, J.N.: J. Chromatogr. 148, 521 (1978)

    Article  CAS  Google Scholar 

  194. Meier, B., Sticher, O.: J. Chromatogr. 138, 453 (1977)

    Article  CAS  Google Scholar 

  195. Sticher, O., Meier, B.: Dtsch. Apoth. Ztg. 120, 1592 (1980)

    CAS  Google Scholar 

  196. Tittel, G., Wagner, H.: J. Chromatogr. 148, 459 (1978)

    Article  CAS  Google Scholar 

  197. Tittel, G., Chari, V.M., Wagner, H.: Planta med. 34, 305 (1978)

    Article  CAS  Google Scholar 

  198. Wulf, L.W., Nagel, C.W.: J. Chromatogr. 116, 271 (1976)

    Article  CAS  Google Scholar 

  199. Adamovics, J., Stermitz, F.R.: J. Chromatogr. 129, 464 (1976)

    Article  CAS  Google Scholar 

  200. Hostettmann, K., McNair, H.M.: J. Chromatogr. 116, 271 (1976)

    Article  Google Scholar 

  201. Hostettmann, K., Jacot-Guillarmod, A.: J. Chromatogr. 124, 381 (1976)

    Article  CAS  Google Scholar 

  202. Pettei, M.J., Hostettmann, K.: J. Chromatogr. 154, 106 (1978)

    Article  CAS  Google Scholar 

  203. Carlson, R.E., Dolphin, D.: J. Chromatogr. 198, 193 (1980)

    Article  CAS  Google Scholar 

  204. Lea, A.G.H.: J. Chromatogr. 194, 62 (1980)

    Article  CAS  Google Scholar 

  205. Lea, A.G.H.: J. Chromatogr. 238, 253 (1982)

    Article  CAS  Google Scholar 

  206. Okuda, T., Mori, K., Seno, K., Hatano, T.: J. Chromatogr. 240, 202 (1982)

    Article  Google Scholar 

  207. Tittel, G., Wagner, H.: J. Chromatogr. 135, 499 (1977)

    Article  CAS  Google Scholar 

  208. Tittel, G., Wagner, H.: J. Chromatogr. 153, 227 (1978)

    Article  CAS  Google Scholar 

  209. Wagner, H., Tittel, G., Bladt, S.: Dtsch. Apoth. Ztg. 123, 515 (1983)

    CAS  Google Scholar 

  210. Tittel, G., Wagner, H.: Proceedings of the International Bioflavonoid Symposium, (D)-Munich, (1981) Elsevier Sc. Publ. Comp., Amsterdam-Oxford-New York (1982)

    Google Scholar 

  211. Daigle, D.J., Conkerton, E.J.: J. Chromatogr. 240, 202 (1982)

    Article  CAS  Google Scholar 

  212. Castelee, K.V., Geiger, H., Sumere, Ch. Van: J. Chromatogr. 240, 81 (1982)

    Article  Google Scholar 

  213. Rouseff, R.L., Ting, S.V.: J. Chromatogr. 176, 75 (1979)

    Article  CAS  Google Scholar 

  214. Radaelli, C., Formentini, L., Santaniello, E.: Planta med. 42, 288 (1981)

    Article  Google Scholar 

  215. Cairnes, D.A., Kingston, D.G.J., Rao, M.: Lloydia 44, 34 (1981)

    CAS  Google Scholar 

  216. Lim, C.K., Ayres, D.C.: J. Chromatogr. 255, 247 (1983)

    Article  CAS  Google Scholar 

  217. Steinigen, M.: Pharm. Ztg. 128, 783 (1983)

    CAS  Google Scholar 

  218. Wagner, H., Heur, Y.H., Obermeier, A., Tittel, G., Bladt, S.: Planta med. 44, 193 (1982)

    Article  CAS  Google Scholar 

  219. Komolafe, O.O.: J. Pharm. Sc. 70, 727 (1981)

    Article  CAS  Google Scholar 

  220. Auterhoff, H., Graf, E., Eurisch, G., Alexa, M.: Arch. Pharm. 313, 113 (1980)

    Article  CAS  Google Scholar 

  221. Graf, E., Alexa, M.: Planta med. 38, 121 (1980)

    Article  CAS  Google Scholar 

  222. Bonati, A., Forni, G.: Fitoterapia 18, 159 (1977)

    Google Scholar 

  223. Forni, G.P.: Fitoterapia 53, 3 (1982)

    CAS  Google Scholar 

  224. Hayashi, S., Yoshido, A., Tanako, H., Mitani, Y., Yoshizawa, K.: Chem. Pharm. Bull. 28, 406 (1980)

    CAS  Google Scholar 

  225. Komolafe, O.O.: J. Pharm. Sc. 16, 496 (1978)

    CAS  Google Scholar 

  226. Görler, K., Mutter, S., Westphal, C.: Planta med. 37, 308 (1979)

    Article  Google Scholar 

  227. Tittel, G., Tittel, Ch.: Bulletin de Liaison u° 11 du Groupe Polyphenols, F-Toulouse, 29.9.–1.10.1982

    Google Scholar 

  228. Fisher, J.F., Wheaton, T.A.: J. Agric. Food Chem. 24, 899 (1976)

    Article  Google Scholar 

  229. Higgins, J.W.: J. Chromatogr. 121, 329 (1976)

    Article  CAS  Google Scholar 

  230. Besso, H., Saruwatari, Y., Futamura, K., Kunihiro, K., Fuwa, T., Tanaka, O.: Planta med. 37, 226 (1979)

    Article  CAS  Google Scholar 

  231. Sticher, O., Soldati, F.: Planta med. 36, 30 (1979)

    Article  CAS  Google Scholar 

  232. Soldati, F., Sticher, O.: Planta med. 39, 348 (1980)

    Article  CAS  Google Scholar 

  233. Schulten, H.R., Soldati, F.: J. Chromatogr. 212, 37 (1981)

    Article  CAS  Google Scholar 

  234. Kimata, H., Hiyama, C., Yahara, S., Tanaka, O., Ishikawa, O., Aiura, M.: Chem. Pharm. Bull, 27, 1836 (1979)

    CAS  Google Scholar 

  235. Lin, J.-T., Heftmann, E.: J. Chromatogr. 207, 457 (1981)

    Article  CAS  Google Scholar 

  236. Gracza, L., Ruff, P.: Dt. Apoth. Ztg. 121, 2817 (1981)

    CAS  Google Scholar 

  237. Herrmann, R.: Dt. Apoth. Ztg. 122, 1797 (1982)

    CAS  Google Scholar 

  238. Kraus, Lj., Stahl, E.: J. Chromatogr. 170, 269 (1979)

    Article  CAS  Google Scholar 

  239. Sticher, O., Soldati, F., Lehmann, D.: Planta med. 35, 233 (1979)

    Article  Google Scholar 

  240. Grevel, J.: Dissertation Uni München (1982)

    Google Scholar 

  241. Bauer, R., Wagner, H.: Dtsch. Apoth. Ztg. 123, 1313 (1983)

    CAS  Google Scholar 

  242. Nomeir, A.A., Abou-Donia, M.B.: J. AOCS 59, 546 (1982)

    CAS  Google Scholar 

  243. Becker, H., Bingler-Timeus, E.: Pharm. Ztg. 128, 1252 (1983)

    CAS  Google Scholar 

  244. Bauer, R., Tittel, G., Wagner, H.: Planta med. 48, 10 (1983)

    Article  CAS  Google Scholar 

  245. Wurst, M., Pikryl, Z., Vankura, V.: J. Chromatogr. 191, 129 (1980)

    Article  CAS  Google Scholar 

  246. Holland, J.A., McKerrell, E.H., Fuell, K.J., Burrows, W.J.: J. Chromatogr. 166, 545 (1978)

    Article  CAS  Google Scholar 

  247. Eiden, F., Tittel, Ch.: Dtsch. Apoth. Ztg. 121, 1874 (1981)

    CAS  Google Scholar 

  248. Ahmed, M.S., Dobberstein, R.H., Farnsworth, N.R.: J. Chromatogr. 192, 387 (1980)

    Article  CAS  Google Scholar 

  249. Ahmed, M.S., Dobberstein, R.H.: J. Chromatogr. 236, 523 (1982)

    Article  CAS  Google Scholar 

  250. Ahmed, M.S., Dobberstein, R.H.: J. Chromatogr. 245, 373 (1982)

    Article  CAS  Google Scholar 

  251. Schwanbeck, Kubeczka

    Google Scholar 

  252. Tittel, G., Bos, R., Wagner, H.: Vortrag: 1. Gesamtkongress der pharmazeutischen Wissenschaften, D-München, 17.–20.4.1983

    Google Scholar 

  253. Wal, Sj. Van der, Huber, J.F.K.: J. Chromatogr. 251, 289 (1982)

    Article  Google Scholar 

  254. Verpoorte, R., Baerheim-Svendsen, A.: J. Chromatogr. 100, 227 (1974)

    Article  CAS  Google Scholar 

  255. Verpoorte, R., Baerheim-Svendsen, A.: J. Chromatogr. 100, 231 (1974)

    Article  CAS  Google Scholar 

  256. Gracza, L.: Dtsch. Apoth. Ztg. 120, 1859 (1980)

    CAS  Google Scholar 

  257. Ali, S.L.: Fresenius Z. Anal. Chem. 299, 124 (1979)

    Article  CAS  Google Scholar 

  258. Verzele, M., Mussche, P., Qureshi, S.A.: J. Chromatogr. 172, 493 (1979)

    Article  CAS  Google Scholar 

  259. Galetto, W.G., Walger, D.E., Levy, S.M.: J. AOAC, 59, 951 (1976)

    CAS  Google Scholar 

  260. Cleyn, R. De, Verzele, M.: Chromatographia 8, 342 (1975)

    Article  Google Scholar 

  261. Sticher, O., Soldati, F., Joshi, R.K.: J. Chromatogr. 166, 221 (1978)

    Article  CAS  Google Scholar 

  262. Henning, W.: Z. Lebensm. Unters. Forsch. 175, 345 (1982)

    Article  CAS  Google Scholar 

  263. Freytag, W.E.: Pharm. Ztg. 128, 2869 (1983)

    CAS  Google Scholar 

  264. Bianchini, J.B., Gaydou, E.M.: J. Chromatogr. 190, 233 (1980)

    Article  CAS  Google Scholar 

  265. Bauer, R.: Dissertation Uni München (1984)

    Google Scholar 

  266. Hänsel, R., Schulz, J.: Dtsch. Apoth. Ztg. 122, 215 (1982)

    Google Scholar 

  267. Tittel, G., Bos, R.: to be published

    Google Scholar 

  268. Hostettmann, K., Pettei, M.J., Kubo, J., Nakanishi, K.: Helv. Chim. Act. 60, 670 (1977)

    Article  CAS  Google Scholar 

  269. Freytag, W.E.: Dissertation TU München (1983)

    Google Scholar 

  270. Vincent, P.G., Engelke, B.F.: J. Assoc. off. anal. Chem. 62, 310 (1979)

    CAS  Google Scholar 

  271. Doner, L.W., An-Fei Hsu: J. Chromatogr. (1982)

    Google Scholar 

  272. Tittel, G., Fiebig, M., Wagner, H.: to be published

    Google Scholar 

  273. Holland, J.A., McKerrell, E.H., Fuell, K.J., Burrows, W.J.: J. Chromatogr. 166, 545 (1978)

    Article  CAS  Google Scholar 

  274. Kovar, K.A., Langlouis, H., Auterhoff, H.: Pharm. Weekblad Sc. Edit. 5, 134 (1983)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratorium für Analysen und Trenntechnik Dr. Tittel GmbH, Maria-Eich-Str. 7, 8032, Gräfelfing/München, Germany

    Gerolf Tittel

  2. Institut für pharmazeutische Biologie Universität München, Karlstr. 29, 8000, München 2, Germany

    Hildebert Wagner

Authors
  1. Gerolf Tittel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hildebert Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Angewandte Physikalische Chemie, Universität des Saarlandes, D-6600, Saarbrücken, Germany

    Heinz Engelhardt

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Tittel, G., Wagner, H. (1983). Application of HPLC to the Analysis of Natural and Synthetic Pharmaceutically Important Drugs. In: Engelhardt, H. (eds) Practice of High Performance Liquid Chromatography. Chemical Laboratory Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69225-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69225-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69227-7

  • Online ISBN: 978-3-642-69225-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation