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Anatomical Studies of Blood Brain Barrier Disruption Following Intracarotid Bile Salt Infusion

  • M. E. Levine
  • M. K. Spigelman
  • R. A. Zappulla
  • J. T. Povlishock
  • L. I. Malis
  • J. F. Holland
Conference paper

Abstract

Experimentally induced blood brain barrier (BBB) disruption by the intracarotid infusion of the bile salt sodium dehy drocholate is under investigation in our laboratories. Although the ability of bile salts to break the BBB has been recognized for over thirty-five Years (Broman and Lindberg-Broman 1945), information concerning the anatomic features of this method of barrier disruption has been previously lacking. The goal of the present investigation is to characterize the morphologic consequences of sodium dehydrocholate induced barrier opening.

Keywords

Blood Brain Barrier Bile Salt Evans Blue Blood Brain Barrier Dysfunction Evans Blue Extravasation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • M. E. Levine
    • 1
  • M. K. Spigelman
    • 1
  • R. A. Zappulla
    • 1
  • J. T. Povlishock
    • 1
  • L. I. Malis
    • 1
  • J. F. Holland
    • 1
  1. 1.Department of NeurosurgeryThe Mount Sinai School of MedicineNew YorkUSA

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