Skip to main content
SpringerLink
Log in

New Trends for the Evaluation of Experimental Brain Edema

  • Conference paper
Intracranial Pressure V

Abstract

As in many fields of experimental neurology, considerable advances have been made in edema research over the past Years. The classical and still valid distinction between cytotoxic and vasogenic edema, made by Klatzo (1967) 15 Years ago, was mainly based on the differences of permeability behavior of the blood-brain barrier to circulating macromolecules, such as fluorescein- or Evans blue-labelled serum proteins. Since this time, the two types of edema have been further characterized by using a variety of physiological, biochemical and morphological techniques, which allowed a more detailed analysis of their pathophysiological pecularities, and thus have provided a rational basis for the development of therapeutic procedures.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bodsch W, Hürter T, Hossmann K-A (1982) Immunochemical method for quantitative evaluation of vasogenic brain edema following cold injury of rat brain. Brain Res, in press

    Google Scholar 

  • Branston NM, Strong AJ, Symon L (1977) Extracellular potassium activity, evoked potential and tissue blood flow. J Neurol Sci 32:305–321

    Article  PubMed  CAS  Google Scholar 

  • Bremer AM, Yamada K, West CR (1980) Ischemic cerebral edema in primates: Effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. Neurosurgery 6:149–154

    Article  PubMed  CAS  Google Scholar 

  • Brightman MW, Klatzo I, Olsson Y, Reese TS (1970) The blood-brain barrier to proteins under normal and pathological conditions. J Neurol Sci 10:215–239

    Article  PubMed  CAS  Google Scholar 

  • Cole KS, Li C-L, Bak AF (1969) Electrical analogues for tissues (1969) Exp Neurol 24:459–473

    Article  PubMed  CAS  Google Scholar 

  • Dietzel I, Heinemann U, Hofmeier G, Lux HD (1980) Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration. Exp Brain Res 40:432–439

    Article  PubMed  CAS  Google Scholar 

  • Elliott KAC, Jasper HH (1949) Measurment of experimentally induced brain swelling and shrinkage. Am J Physiol 157:122–129

    PubMed  CAS  Google Scholar 

  • Hansen AJ, Olsen CE (1980) Brain extracellular space during spreading depression and ischemia. Acta Physiol Scand 108:355–365

    Article  PubMed  CAS  Google Scholar 

  • Hossmann K-A, Bloink M (1981) Blood flow and regulation of blood flow in experimental peritumoral edema. Stroke 12:211–217

    Article  Google Scholar 

  • Hossmann K-A, Matsuoka Y, Blöink M, Fitzgerald G, Hossmann V (1981) Treatment of experimental infarction of the cat brain. In: Cahn J (ed) Drugs and Methods in Cerebrovascular diseases. Pergamon Press, Paris, p 427–434

    Google Scholar 

  • Hossmann K-A, Schuier FJ (1980) Experimental brain infarcts in cats. I. Pathophysiological observations. Stroke 11:583–592

    Article  PubMed  CAS  Google Scholar 

  • Hossmann K-A, Tagagi S (1976) Osmolality of brain in cerebral ischemia. Exp Neurol 51:124–131

    Article  Google Scholar 

  • Hossmann K-A, Wechsler W, Wilmes F (1979) Experimental peritumorous edema. Morphological and pathophysiological observations. Acta Neuropathol (Berl) 45:195–203

    Article  CAS  Google Scholar 

  • Hudgins WR, Garcia JH (1970) Transorbital approach to the middle cerebral artery of the squirrel monkey: A technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke 1:107–111

    Article  PubMed  CAS  Google Scholar 

  • Kamijyo Y, Garcia JH, Cooper J (1977) Temporary regional cerebral ischemia in the cat. A model of hemorrhagic and subcortical infarction. J Neuropathol Exp Neurol 36:338–350

    Article  PubMed  CAS  Google Scholar 

  • Klatzo I (1967) Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26:1–14

    Article  PubMed  CAS  Google Scholar 

  • Klatzo I, Chui E, Fujiwara K, Spatz M (1980) Resolution of vasogenic brain edema (VBE). Adv Neurol 28:359–373

    PubMed  CAS  Google Scholar 

  • Klatzo I, Wisniewski H, Stein wall O, Streicher E (1967) Dynamics of cold injury edema. In: Klatzo I, Seitelberger F (eds) Brain Edema. Springer, New York, p 554–563

    Google Scholar 

  • Kogure K, Alonso OF (1978) A pictorial representation of endogenous brain ATP by a bioluminescent method. Brain Res 154:273–284

    Article  PubMed  CAS  Google Scholar 

  • Little JR (1978) Modification of acute focal ischemia by treatment with mannitol and high-dose dexamethasone. J Neurosurg 49:517–524

    Article  PubMed  CAS  Google Scholar 

  • Little JR, O’Shaughnessy D (1979) Treatment of acute focal ischemia with continuous CSF drainage and mannitol. Stroke 10:446–450

    Article  PubMed  CAS  Google Scholar 

  • Matsuoka Y, Hossmann K-A (1981) Corticosteroid therapy of experimental tumour oedema. Neurosurg Rev 4:185–190

    Article  PubMed  CAS  Google Scholar 

  • Matsuoka Y, Hossmann K-A (1982) Brain tissue osmolality following middle cerebral artery occlusion in cats. Exp Neurol, in press

    Google Scholar 

  • Matsuoka Y, Hossmann K-A (1982) Cortical impedance and extracellular volume changes following middle cerebral artery occlusion in cats. J Cereb Blood Flow Metabol, in press

    Google Scholar 

  • Mies G, Bodsch W, Paschen W, Hossmann K-A (1982) Experimental application of triple-labelled quantitative autoradiography for measurement of cerebral blood flow, glucose metabolism and protein biosynthesis. In: Heiss W-D, Phelps ME (eds) Positron Emission Tomography of the Brain. Springer, Berlin Heidelberg New York, in press

    Google Scholar 

  • Nelson SR, Mantz ML, Maxwell H (1971) Use of specific gravity in the measurement of brain edema. J Appl Physiol 30:268–271

    PubMed  CAS  Google Scholar 

  • O’Brien MD, Waltz AG (1973) Transorbital approach for occluding the middle cerebral artery without craniectomy. Stroke 4:201–206

    Article  PubMed  Google Scholar 

  • Olsson Y, Crowell RM, Klatzo I (1971) The blood-brain barrier to protein tracers in focal cerebral ischemia and infarction caused by occlusion of the middle cerebral artery. Acta Neuropathol (Berl) 18:89–102

    Article  CAS  Google Scholar 

  • Paschen W, Niebuhr I, Hossmann K-A (1981) A bioluminescence method for the demonstration of regional glucose distribution in brain slices. J Neurochem 36:513–517

    Article  PubMed  CAS  Google Scholar 

  • Pöll W, Brock M, Markakis E, Winkelmüller W, Dietz H (1972) Brain tissue pressure. In: Brock M, Dietz H (eds) Intracranial Pressure. Springer, Berlin Heidelberg New York, p 188–194

    Chapter  Google Scholar 

  • Rasmussen LE, Klatzo I (1969) Protein and enzyme changes in cold injury edema. Acta Neuropathol (Berl) 13:12–28

    Article  CAS  Google Scholar 

  • Reulen HJ, Graham R, Saptz M, Klatzo I (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg 46:24–35

    Article  PubMed  CAS  Google Scholar 

  • Rosengren LE, Persson LI (1979) Chlorpromazine treatment of blood-brain barrier dysfunction. A quantitative and fluorescence microscopical study on small cerebral stab wounds in the rat. Acta Neuropathol 46:145–150

    Article  PubMed  CAS  Google Scholar 

  • Schuier FJ, Hossmann K-A (1980) Experimental brain infarcts in cats. II. Ischemic brain edema. Stroke 11:593–601

    Article  PubMed  CAS  Google Scholar 

  • Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification on spirochetes. J Histochem Cytochem 18:315–333

    Article  PubMed  CAS  Google Scholar 

  • Symon L, Branston NM, Chikovani O (1979) Ischemic brain edema following middle cerebral artery occlusion in baboons: Relationship between regional cerebral water content and blood flow at 1 to 2 hours. Stroke 10:184–191

    Article  PubMed  CAS  Google Scholar 

  • Welsh FA, Rieder W (1978) Evaluation of in situ freezing of cat brain by NADH fluorescence. J Neurochem 31:299–309

    Article  PubMed  CAS  Google Scholar 

  • Wilmes F, Hossmann K-A (1979) A specific immunofluorescence technique for the demonstration of vasogenic brain edema in paraffin embedded material. Acta Neuropathol (Berl) 45:47–51

    Article  CAS  Google Scholar 

  • Zülch KJ (1953) Hirnschwellung und Hirnödem. Dtsch Z Nervenheilk 170:179–208

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Experimentelle Neurologie, Max-Planck-Institut für Neurologische Forschung, Ostmerheimerstrasse 200, D-5000, Köln 91, Germany

    K.-A. Hossmann

Authors
  1. K.-A. Hossmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

    Shozo Ishii M. D.

  2. Department of Neurosurgery, Nagoya City University, Medical School, 1 Kawasumi, Mizuho-ku, Nagoya 467, Japan

    Hajime Nagai M. D.

  3. Neurochirurgische Klinik und Poliklinik, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    Mario Brock

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Hossmann, KA. (1983). New Trends for the Evaluation of Experimental Brain Edema. In: Ishii, S., Nagai, H., Brock, M. (eds) Intracranial Pressure V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69204-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69204-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69206-2

  • Online ISBN: 978-3-642-69204-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation