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Regulatory Control of Interferon Synthesis and Action

  • Chapter
Interferons and Their Applications

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 71))

Abstract

The induction of interferon (IFN) consists of a series of cellular events resulting in the transcription and translation of the IFN genes followed by events leading to the curtailment of these activities. After induction, cells remain refractory for several hours before they can be stimulated for IFN synthesis again. Much could be learned of mammalian gene regulation from the mechanism or mechanisms by which IFN genes are stimulated and regulated. This chapter reviews the evidence regarding the number and nature of human IFN genes and the progress toward understanding the regulation of their expression.

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  1. H. Smith-Johannsen
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  2. Y-T. Hou
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  3. X-Y. Liu
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  4. Y-H. Tan
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Editors and Affiliations

  1. HEM Research Inc., 12280 Wilkins Avenue, Rockville, MD, 20852, USA

    Paul E. Came Ph.D.

  2. Clinical Research, Department of Oncology, Orlowitz Cancer Institute, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

  3. Department of Hematology and Oncology, Hahnemann University of Health Sciences, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

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Smith-Johannsen, H., Hou, YT., Liu, XY., Tan, YH. (1984). Regulatory Control of Interferon Synthesis and Action. In: Came, P.E., Carter, W.A. (eds) Interferons and Their Applications. Handbook of Experimental Pharmacology, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69178-2_6

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