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Interferons and Their Applications pp 433–453Cite as

Clinical Use of Interferons: Localized Application in Viral Diseases

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 71))

Abstract

Since the original reports by Isaacs and Lindenmann (1957 a, b), the use of interferon (IFN) in the prevention and treatment of virus infections has been anticipated. Because of its broad spectrum of antiviral activity, viral infections of the respiratory tract, eye, and skin have been appropriate targets for the potential utilization of IFN. However, only in the past few years have sufficient quantities of IFN been available for clinical evaluation in humans. Thus, there have been few controlled studies with HuIFN, but several anecdotal reports. This chapter will focus on both the basic anatomic and physiologic considerations which pertain to clinical efficacy, and the studies performed to date with locally applied IFN.

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  1. S. B. Greenberg
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  2. M. W. Harmon
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Editors and Affiliations

  1. HEM Research Inc., 12280 Wilkins Avenue, Rockville, MD, 20852, USA

    Paul E. Came Ph.D.

  2. Clinical Research, Department of Oncology, Orlowitz Cancer Institute, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

  3. Department of Hematology and Oncology, Hahnemann University of Health Sciences, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

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Greenberg, S.B., Harmon, M.W. (1984). Clinical Use of Interferons: Localized Application in Viral Diseases. In: Came, P.E., Carter, W.A. (eds) Interferons and Their Applications. Handbook of Experimental Pharmacology, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69178-2_21

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  • DOI: https://doi.org/10.1007/978-3-642-69178-2_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69180-5

  • Online ISBN: 978-3-642-69178-2

  • eBook Packages: Springer Book Archive

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