Nonpolynucleotide Inducers of Interferon
Following the discovery of interferon, a great deal of interest centered around developing methods of clinically utilizing this interesting material. During the 1950s and early 1960s, attention was given to the problem of producing interferon in cultured cells in vitro which could be purified and concentrated for exogenous transfer to the exposed or infected host. In the early 1960s, a small number of workers became interested in the possibility that an animal’s own cells could be stimulated to produce their own endogenous interferon in vivo. These studies were stimulated by the discovery of Steinebring and Youngner (1964) that an extract of gram-negative organisms, a lipopolysacchride (endotoxin), would induce a detectable interferon response when injected into mice. Consequently, interest centered around the potential use of molecules such as lipopolysaccharide to induce detectable levels of interferon in vivo.
KeywordsPlacebo Sarcoma Interferon Prostaglandin Pyran
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