Skip to main content
SpringerLink
Log in
Book cover

Interferons and Their Applications pp 339–355Cite as

Comparative Biologic Activities of Human Interferons

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 71))

Abstract

Interferons have been shown to have a number of biologic activities other than the antiviral properties which first led to their discovery. Since the identification of interferon by Issacs and Lindenmann in 1957, numerous studies have been directed toward understanding the multiple effects these proteins have on cellular functions and immune responses (Stewart 1981). Although virus-induced interferons, the classical interferons, have been studied more extensively, primarily because of their availability, it is now well recognized that interferon induced as a result of immune reactions is also a potent antiviral agent (Green et al. 1969). This immune interferon first described by Wheelock (1965) also has antiproliferative and immunoregulatory activities. However, it differs in its stability at low pH and the conditions required to induce it.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Apostolov K, Barker W (1981) The effects of interferon on the fatty acids in uninfected cells. FEBS Lett 126:261–264

    PubMed  CAS  Google Scholar 

  • Balkwill FR, Oliver RTD (1977) Inhibitory effects of interferon on normal and malignant human haemopoietic cells. Int J Cancer 20:500–505

    PubMed  CAS  Google Scholar 

  • Baron S, Brunell PA, Grossberg SE (1979) Mechanisms of action and pharmacology: the immune and interferon systems. In: Galasso GJ, Merigan TC, Buchanan RA (eds) Antiviral agents and viral diseases of man. Raven, New York, pp 151–209

    Google Scholar 

  • Billiau A, De Somer P, Edy VG, De Clercq E, Heremens H (1979) Human fibroblast interferon for clinical trials: pharmacokinetics and tolerability in experimental animals and humans. Antimicrob Agents Chemother 16:56

    PubMed  CAS  Google Scholar 

  • Blalock JE, Georgiades JA, Langford MP, Johnson HM (1980) Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon. Cell Immunol 49:390–394

    PubMed  CAS  Google Scholar 

  • Block LH, Cantell K, Jamberger S, Ruhevstroth-Bauer G, Strander H (1977) Lack of correspondence between human leukocyte type I interferon and human migration inhibitory factor. Arch Virol 56:341–344

    Google Scholar 

  • Blomgren H, Einhorn S (1981) Lymphokine production by PHA-stimulated human lymphocytes is enhanced by interferon. Int Arch Allergy Appl Immunol 66:173–178

    PubMed  CAS  Google Scholar 

  • Blomgren H, Strander H, Cantell K (1974) Effect of human leukocyte interferon on the response of lymphocytes to mitogenic stimuli in vitro. Scand J Immunol 3:697–705

    PubMed  CAS  Google Scholar 

  • Bocci V (1977) Distribution of interferon in body fluids and tissues. Tex Rep Biol Med 35:436–442

    PubMed  CAS  Google Scholar 

  • Bocci V (1981) Pharmacokinetic studies of interferons. Pharmacol Ther 13:421–440

    PubMed  CAS  Google Scholar 

  • Bocci V, Pacini A, Muscettola M, Paulesu L, Pessina GP (1981) Renal metabolism of rabbit serum interferon. J Gen Virol 55:297–304

    PubMed  CAS  Google Scholar 

  • Bradley EC, Ruscetti FW (1981) Effect of fibroblast, lymphoid and myeloid interferons on human tumor colony formation in vitro. Cancer Res 41:244–249

    PubMed  CAS  Google Scholar 

  • Came PE, Schafer TW, Silver GH (1976) Sensitivity of rhinoviruses to human leukocyte and fibroblast interferons. J Infect Dis 133:Suppl A136–139

    PubMed  Google Scholar 

  • Cantell K, Hirvonen S (1977) Preparation of human leukocyte interferon for clinical use. Tex Rep Biol Med 35:138–144

    PubMed  CAS  Google Scholar 

  • Cantell K, Phyala L (1973) Circulating interferon in rabbits after administration of human interferon by different routes. J Gen Virol 20:97–104

    PubMed  CAS  Google Scholar 

  • Cantell K, Phyala L, Strander H (1974) Circulating human interferon after intramuscular injection into animals and man. J Gen Virol 25:453–458

    PubMed  CAS  Google Scholar 

  • Catalona WJ, Ratliff TL, McCool RE (1981) Gamma interferon induced by Staphylococcus aureus protein A augments natural killing and antibody-dependent cell-mediated cytotoxicity. Nature 291:77–79

    PubMed  CAS  Google Scholar 

  • Cesario T, Vaziri N, Slater L, Tilles J (1979) Inactivators of fibroblast interferon found in human serum. Infect Immun 24:851

    PubMed  CAS  Google Scholar 

  • Chang TW, Testa D, Kung PC, Perry L, Dreskin HJ, Goldstein G (1982) Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody. J Immunol 128:585–589

    PubMed  CAS  Google Scholar 

  • Chany C (1981) Reorganization of the cytoskeleton by interferon in MSV-transformed cells. J Interferon Res 1:323–332

    PubMed  Google Scholar 

  • Choi YS, Lim KH, Sanders FK (1981) Effect of interferon alpha on pokeweed mitogen-in-duced differentiation of human peripheral blood lymphocytes. Cell Immunol 64:20–28

    PubMed  CAS  Google Scholar 

  • Cooper HL, Fagnani R, London J, Trepel J, Lester EP (1982) Effect of interferons on protein synthesis in human lymphocytes: enhanced synthesis of eight specific peptides in T cells and activation-dependent inhibition of overall protein synthesis. J Immunol 128:828–833

    PubMed  CAS  Google Scholar 

  • Creasey AA, Bartholomew JC, Merigan TC (1980) Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon. Proc Natl Acad Sci USA 77:1471–1475

    PubMed  CAS  Google Scholar 

  • Cupples CG, Tan YH (1977) Effect of human interferon preparations on lymphoblastogenesis in Down’s syndrome. Nature 267:165–167

    PubMed  CAS  Google Scholar 

  • De Maeyer E, De Maeyer-Guignard J (1981) Interferons as regulatory agents of the immune system. CRC Crit Rev Immunol 2:167–188

    Google Scholar 

  • Derynck R, Remaut E, Saman E, Stanssens P, DeClercq E, Content J, Fiers W (1980) Expression of human fibroblast interferon gene in Eschericha coli. Nature 287:193–197

    PubMed  CAS  Google Scholar 

  • Desmyter J, Stewart WE II (1976) Molecular modification of interferon: attainment of human interferon in a conformation active on cat cells but inactive on human cells. Virology 70:451–458

    PubMed  CAS  Google Scholar 

  • Desmyter J, Rawls WE, Melnick JL (1968) A human interferon that crosses the species line. Proc Natl Acad Sci USA 59:69–76

    PubMed  CAS  Google Scholar 

  • Dianzani F, Salter L, Fleischmann JR WR, Zucca M (1978) Immune interferon activates cells more slowly than does virus-induced interferon. Proc Soc Exp Biol Med 159:94–99

    PubMed  CAS  Google Scholar 

  • Edy VG, Billiau A, De Somer P (1976) Human fibroblast and leukocyte interferons show different dose-response curves in assay of cell protection. J Gen Virol 31:251–255

    PubMed  CAS  Google Scholar 

  • Edy VG, Billiau V, Joniau M, De Somer P (1979) Stabilization of mouse and human interferons by acid pH against inactivation due to shaking and guanidine hydrochloride. Proc Soc Exp Biol Med 146:249–253

    Google Scholar 

  • Einhorn S, Strander H (1977) Is interferon tissue specific. Effect of human leukocyte and fibroblast interferons on the growth of lymphoblastoid and osteosarcoma cell lines. J Gen Virol 35:573–577

    PubMed  CAS  Google Scholar 

  • Emodi G, Just M, Hernandez R, Hirt HR (1975) Circulating interferon in man after administration of exogenous human leukocyte interferon. J Natl Cancer Inst 54:1045–1048

    PubMed  CAS  Google Scholar 

  • Ennis FA, Meager A (1981) Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus. J Exp Med 154:1279–1289

    PubMed  CAS  Google Scholar 

  • Epstein LB (1977) The effects of interferons on the immune response in vitro and in vivo. In: Stewart WE II (ed) Interferons and their actions. CRC, Cleveland, p 91

    Google Scholar 

  • Epstein LB (1979) The comparative biology of immune and classical interferons. In: Cohen S, Pick E, Oppenheim JJ (eds) Biology of the lymphokines. Academic New York, p 443

    Google Scholar 

  • Epstein LB, Gupta S (1981) Human T-lymphocyte subset production of immune (gamma) interferon. Clin Immunol 1:186–194

    CAS  Google Scholar 

  • Epstein LB, Cline MJ, Merigan TC (1971a) PPD-stimulated interferon: in vitro macrophage-lymphocyte interaction in the production of a mediator of cellular immunity. Cell Immunol 2:602–613

    PubMed  CAS  Google Scholar 

  • Epstein LB, Cline MJ, Merigan RC (1971b) The interaction of human macrophages and lymphocytes in the phytohemagglutinin stimulated production of interferon. J Clin Invest 50:744–753

    PubMed  CAS  Google Scholar 

  • Epstein LB, Stevens DA, Merigan TC (1972) Selective increase in lymphocyte interferon response to vaccinia antigen after revaccination. Proc Natl Acad Sci USA 69:2632–2636

    PubMed  CAS  Google Scholar 

  • Falcoff E, Falcoff R, Catinot L, Vomecourt A, Sanceau J (1972) Synthesis of interferon in human lymphocytes stimulated in vitro by antilymphocytic serum. Rev Eur Etud Clin Biol 17:20–26

    PubMed  CAS  Google Scholar 

  • Fleischmann Jr WR (1977) Priming of interferon action. Tex Rep Biol Med 35:316–325

    PubMed  CAS  Google Scholar 

  • Fleischmann WR, Georgiades JA, Osborne LC, Johnson HM (1979) Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon. Infect Immun 26:248–253

    PubMed  Google Scholar 

  • Gewert DR, Shah S, Clemens MJ (1981) Inhibition of cell division by interferons. Changes in the transport and intracellular metabolism of thymidine in human lymphoblastoid (Daudi) cells. Eur J Biochem 116:487–492

    PubMed  CAS  Google Scholar 

  • Goeddel DV, Shepard HM, Yelverton E, Leung D, Crea R, Sloma A, Pestka S (1980a) Synthesis of human fibroblast interferon by E. coli. Nucleic Acids Res 8:4057–4074

    PubMed  CAS  Google Scholar 

  • Goeddel DV, Yelverton E, Ullrich A, Heyneker HL, Miozzari G, Holmes W, Seeburg P, Dull T, May L, Stebbing N, Crea R, Maeda S, McCandliss R, Sloma A, Tabor JM, Gross M, Familletti PC, Pestka S (1980b) Human leukocyte interferon produced in E. coli is biologically active. Nature 287:411–416

    PubMed  CAS  Google Scholar 

  • Goeddel DV, Leung DW, Dull TJ, Gross M, McCandliss R, Lawn RM, Seeburg PH, Ullrich A, Yelverton E, Gray PW (1981) The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature 290:20–26

    PubMed  CAS  Google Scholar 

  • Gray PW, Leung DW, Pennica D, Yelverton E, Najarian R, Simonsen CC, Derynck R, Sherwood PJ, Wallace DM, Berger SL, Levinson AD, Goeddel DV (1982) Expression of human immune interferon cDNA in E. coli and monkey cells. Nature 295:503–508

    PubMed  CAS  Google Scholar 

  • Green JA, Cooperband SR, Kibrick S (1969) Immune specific induction of interferon production in cultures of human blood lymphocytes. Science 164:1415–1417

    PubMed  CAS  Google Scholar 

  • Gresser I, Tovey MG (1978) Antitumor effects of interferon. Biochim Biophys Acta 516:231–247

    PubMed  CAS  Google Scholar 

  • Gresser I, Bandu MT, Brouty-Boye D, Tovey M (1974) Pronounced antiviral activity of human interferon on bovine and porcine cells. Nature 251:543–545

    PubMed  CAS  Google Scholar 

  • Guarari-Rotman D, Revel M, Tartakovsky B, Segal S, Hahn T, Handzel Z, Levin S (1978) Lymphoblastogenesis in Down’s syndrome and its inhibition by human interferon. FEBS Lett 94:187–190

    Google Scholar 

  • Habif DV, Lipton R, Cantell K (1975) Interferon crosses blood-brain barrier in monkeys. Proc Soc Exp Biol Med 149:287–293

    PubMed  CAS  Google Scholar 

  • Hanley DF, Wiranowska-Stewart M, Stewart II WE (1979) Pharmacology of interferons I. Pharmacologic distinctions between human leukocyte and fibroblast interferons. Int J Immunopharmacol 1:219–226

    PubMed  CAS  Google Scholar 

  • Harfast B, Huddlestone JR, Casali P, Merigan TC, Oldstone MB (1981) Interferon acts directly on human B lymphocytes to modulate immunoglobulin synthesis. J Immunol 127:2146–2150

    PubMed  CAS  Google Scholar 

  • Harkins R, Hass PE, Aggarwal BB, Apperson S, Weck PK (to be published) Structural and biological properties of purified bacteria-derived human fibroblast interferon. Proc Natl Acad Sci USA

    Google Scholar 

  • Havell EA, Vilcek J (1972) Production of high-titered interferon in cultures of human diploid cells. Antimicrob Agents Chemother 2:476–484

    PubMed  CAS  Google Scholar 

  • Havell EA, Berman B, Ogburn CA, Berg K, Pancker K, Vilcek J (1975) Two antigenically distinct species of human interferon. Proc Natl Acad Sci USA 72:2185–2190

    PubMed  CAS  Google Scholar 

  • Herberman RB, Ortaldo JR, Rubinstein M, Pestka S (1981) Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon. J Clin Immunol 1:149–153

    PubMed  CAS  Google Scholar 

  • Heron I, Berg K, Cantell K (1976) Regulatory effect of interferon on T cells in vitro. J Immunol 117:1370–1373

    PubMed  CAS  Google Scholar 

  • Hilfenhaus J, Thierfelder H, Barth R (1975) Sensitivity of various primate cells and animal viruses to the antiviral activity of human leukocyte interferon. Arch Virol 48:203–211

    PubMed  CAS  Google Scholar 

  • Hilfenhaus J, Damm H, Karges HE, Manthey KF (1976) Growth inhibition of human lymphoblastoid Daudi cells in vitro by interferon preparations. Arch Virol 51:87–97

    PubMed  CAS  Google Scholar 

  • Hilfenhaus J, Damm H, Johannsen R (1977a) Sensitivity of various human lymphoblastoid cells to the antiviral and anticellular activity of human leukocyte interferon. Arch Virol 54:271–277

    PubMed  CAS  Google Scholar 

  • Hilfenhaus J, Weinmann E, Major M, Barth R, Jaeger O (1977 b) Administration of human interferon to rabies virus-infected monkeys after exposure. J Infect Dis 135:846–849

    PubMed  CAS  Google Scholar 

  • Horoszewicz JS, Leong SS, Carter WA (1979) Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon. Science 206:1091–1093

    PubMed  CAS  Google Scholar 

  • Houghton M, Jackson IJ, Porter AG, Doel SM, Catlin GH, Barber C, Carey NH (1981) The absence of introns within a human fibroblast gene. Nucleic Acids Res 9:247–266

    PubMed  CAS  Google Scholar 

  • Isaacs A, Lindenmann J (1957) Virus interference I. The interferon. Proc R Soc Lond [Biol] 147:268–273

    CAS  Google Scholar 

  • Ito M, Buffett RF (1981) Cytocidal effect of purified human fibroblast interferon on tumor cells in vitro. J Natl Cancer Inst 66:819–826

    PubMed  CAS  Google Scholar 

  • Kadish AS, Tansey FA, Yu GS, Doyle AT, Bloom BR (1980) Interferon as a mediator of human lymphocyte suppression. J Exp Med 151:637–650

    PubMed  CAS  Google Scholar 

  • Klimpel GR, Day KD, Lucas DO (1975) Differential production of interferon and lymphotoxin by human tonsil lymphocytes. Cell Immun 20:187–189

    CAS  Google Scholar 

  • Klimpel GR, Dean JH, Day KD, Chen PB, Lucas DO (1977) Lymphotoxin and interferon production by rosette-separated human peripheral lymphocytes. Cell Immun 32:293–297

    CAS  Google Scholar 

  • Knight E (1976) Antiviral and cell growth inhibitory activities reside in the same glycoprotein of human fibroblast interferon. Nature 262:302–303

    PubMed  CAS  Google Scholar 

  • Kronenberg LH (1977) Interferon production by individual cells in culture. Virology 76:634–642

    PubMed  CAS  Google Scholar 

  • Kuwata T, Fuse A, Suzuki N, Morinaga N (1979) Comparison of the suppression of cell and virus growth in transformed human cells of leukocyte and fibroblast interferon. J Gen Virol 43:435–439

    PubMed  CAS  Google Scholar 

  • Langford MP, Georgiades JA, Stanton GJ, Dianzani F, Johnson HM (1979) Large scale production and physicochemical characterization of human immune interferon. Infect Immun 26:36–41

    PubMed  CAS  Google Scholar 

  • Laufs R, Steinke H, Jacobs C, Hilfenhaus J, Karges H (1974) Influence of interferon on the replication of oncogenic herpes viruses in tissue cultures and in nonhuman primates. Med Microbiol Immunol 160:285–294

    PubMed  CAS  Google Scholar 

  • Lawn RM, Adelman J, Dull TJ, Gross M, Goeddel DV, Ullrich A (1981a) DNA sequence of two closely linked human interferons. Science 212:1159–1162

    PubMed  CAS  Google Scholar 

  • Lawn RM, Adelman J, Franke AE, Houck CM, Gross M, Najarian R, Goeddel DV (1981b) Human fibroblast interferon gene lacks interons. Nucleic Acids Res 9:1045–1052

    PubMed  CAS  Google Scholar 

  • Lawn RM, Gross M, Houck CM, Franke AE, Gray PW, Goeddel DV (1981c) DNA sequence of a major human leukocyte interferon gene. Proc Natl Acad Sci USA 78:5435–5439

    PubMed  CAS  Google Scholar 

  • Lee SH, Kelley S, Chiu H, Stebbing N (1982) Stimulation of natural killer cell activity and inhibition of proliferation of various leukemic cells by purified human leukocyte interferon sub-types. Cancer Res 42:1312–1316

    PubMed  CAS  Google Scholar 

  • Lee SH, Weck PK, Moore J, Chen S, Stebbing N (to be published) Pharmacological comparison of two hybrid recombinant DNA-derived human leukocyte interferons. In: Merigan TC, Friedman R, Fox CF (eds) Chemistry and biology of interferons: relationship to therapeutics, UCLA symp mol cell biol 25. Academic, New York

    Google Scholar 

  • Lin LS, Wiranowska-Stewart M, Chudzio T, Stewart WE II (1978) Characterization of the heterogeneous molecules of human interferons: differences in cross-species antiviral acitivities of various molecular populations in human leukocyte interferons. J Gen Virol 39:125–130

    PubMed  CAS  Google Scholar 

  • Lundblad D, Lundgren E (1981) Block of glioma cell line in S by interferon. Int J Cancer 27:749–754

    PubMed  CAS  Google Scholar 

  • Lundgren E, Larsson I, Miorner H, Strannegard O (1979) Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle. J Gen Virol 42:589–595

    PubMed  CAS  Google Scholar 

  • Lvovsky E, Levine DH, Fucillo D, Ablashi DV, Bengal ZH, Armstrong GR, Levy HB (1981) Epstein-Barr virus and herpes virus saimiri: sensitivity to interferons and interferon inducers. J Natl Cancer Inst 66:1013–1019

    PubMed  CAS  Google Scholar 

  • Masucci MG, Szigeti R, Klein E, Gruest J, Montagnier L, Taira H, Hall A, Nagata S, Weissmann C (1980) Effect of interferon-αl from E. coli on some cell functions. Science 209:1431–1435

    PubMed  CAS  Google Scholar 

  • McNeill TA, Gresser I (1973) Inhibition of haemopoietic colony growth by interferon preparations from different sources. Nature 244:173–174

    CAS  Google Scholar 

  • Miorner H, Landstrom LE, Larner E, Larson I, Lundgren E, Strannegard O (1978) Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins. Cell Immunol 35:15–24

    PubMed  CAS  Google Scholar 

  • Muniz A, Carrasco L (1981) Protein synthesis and membrane integrity in interferon-treated HeLa cells infected with encephalomyocarditis virus. J Gen Virol 56:153–162

    Google Scholar 

  • Nakane A, Minagawa T (1981) Alternative induction of interferon alpha and interferon gamma by Listeria monocytogenes in human peripheral blood mononuclear leukocyte cultures. J Immunol 126:2139–2142

    PubMed  CAS  Google Scholar 

  • Neumann-Haeflin D, Sundmacher R, Skoda R, Cantell K (1977) Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. Infect Immun 17:468–470

    Google Scholar 

  • Nissen C, Speck B, Emodi G, Iscove NM (1977) Toxicity of human leukocyte interferon preparations in human bone-marrow cultures. Lancet i:203–204

    Google Scholar 

  • Overall JC, Tze-Jou Y, Kern ER (1980) Sensitivity of herpes simplex virus types 1 and 2 to three preparations of human interferon. J Infect Dis 142:943

    PubMed  Google Scholar 

  • Owerbach D, Rutter WJ, Shows TB, Gray P, Goeddel DV, Lawn RM (1981) Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci USA 78:3123–3127

    PubMed  CAS  Google Scholar 

  • Parker MA, Mandel AD, Wallace JH, Sonnenfeld G (1981) Modulation of the human in vitro antibody response by human leukocyte interferon preparations. Cell Immunol 58:464–469

    PubMed  CAS  Google Scholar 

  • Paucker K, Dalton BJ, Torma ET, Osburn CA (1977) Biological properties of human leukocyte interferon components. J Gen Virol 35:341–351

    PubMed  CAS  Google Scholar 

  • Paucker K, Dalton BJ, Torma ET (1978) Antigenic properties and heterospecific antiviral activities of human leukocyte interferon species. Adv Exp Med Biol 110:75–84

    PubMed  CAS  Google Scholar 

  • Peri G, Polentarutti N, Sessa C, Mangioni C, Mantovani A (1981) Tumoricidal activity of macrophages isolated from human ascitic and solid ovarian carcinomas: augmentation by interferon, lymphokines and endotoxin. Int J Cancer 28:143–152

    PubMed  CAS  Google Scholar 

  • Rasmussen LE, Jordan GW, Stevens DA, Merigan TC (1974) Lymphocyte interferon production and transformation after herpes simplex infections in humans. J Immunol 112:728–736

    PubMed  CAS  Google Scholar 

  • Rich SA (1981) Human lupus inclusions and interferon. Science 213:772–775

    PubMed  CAS  Google Scholar 

  • Rubin BY, Gupta SL (1980) Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents. Proc Natl Acad Sci USA 77:5928–5932

    PubMed  CAS  Google Scholar 

  • Sehgal PB, Pfeffer LM, Tamm I (1982) Interferon and its inducers. In: Came PE, Caliguiri LA (eds) Chemotherapy of viral infections. Springer, Berlin Heidelberg New York, pp 205–311 (Handbook of experimental pharmacology, vol 61)

    Google Scholar 

  • Skreko F, Zajac T, Bahnsen HP, Haff RF, Cantell K (1973) The kinetics of human interferon clearance in gibbons. Proc Soc Exp Biol Med 142:946–947

    PubMed  CAS  Google Scholar 

  • Smolin G, Stebbing N, Friedlander M, Friedlander R, Okumoto M (1982) Natural and cloned human leukocyte interferon in herpes virus infections of rabbit eyes. Arch Opthalmol 100:481–483

    CAS  Google Scholar 

  • Stebbing N, Weck PK, Fenno JT, Apperson S, Lee SH (1981) Comparison of the biological properties of natural and recombinant DNA derived human interferons. In: Shellekens H (ed) Biology of the interferon system. Elsevier-North Holland, New York, p 25

    Google Scholar 

  • Stebbing N, Weck PK, Fenno JT, Rinderknecht E, Estell DA (to be published) Antiviral effects of bacteria derived human leukocyte interferons against encephalomyocarditis virus infection of squirrel monkeys. Arch Virol

    Google Scholar 

  • Stewart WE II (1981) The interferon system. Springer, Wien New York

    Google Scholar 

  • Stewart WE II, Desmyter J (1975) Molecular heterogeneity of human leukocyte interferon: two populations differing in molecular weights, requirements for renaturation and cross-species antiviral activity. Virology 67:68–78

    PubMed  CAS  Google Scholar 

  • Stewart WE II, Gresser LB, Lockart RZ (1971) Priming: a non-antiviral function of interferon. J Virol 1:792–801

    Google Scholar 

  • Stewart WE II, De Somer P, Edy VG, Paucker K, Berg K, Osburne CA (1975) Distinct molecular species of human interferons: requirements for stabilization and reactivation of human leukocte and fibroblast interferons. J Gen Virol 26:327–331

    Google Scholar 

  • Stewart WE II, Gresser I, Tovey MG, Bandu MT, Goff SL (1976) Identification of the cell multiplication inhibitory factors in interferons. Nature 252:300–302

    Google Scholar 

  • Stewart WE II, Sarkar FH, Taira H, Hall A, Nagata S, Weissmann C (1980) Comparisons of several biological and physicochemical properties of human leukocyte interferons produced by human leukocytes and E. coli. Gene 11:181–186

    PubMed  CAS  Google Scholar 

  • Streuli M, Nagata S, Weissmann C (1980) At least three human type alpha interferons: structure of alpha-two. Science 209:1343–1347

    PubMed  CAS  Google Scholar 

  • Sugiyama M, Epstein LB (1978) Effect of Corynebacterium parvum on human T-lymphocyte interferon production and T-lymphocyte proliferation in vitro. Cancer Res. 38:4467–4473

    PubMed  CAS  Google Scholar 

  • Taniguchi T, Mantei N, Schwarzstein M, Nagata S, Muramatsu M, Weissmann C (1980a) Human leukocyte and fibroblast interferons are structurally related. Nature 285:547–549

    PubMed  CAS  Google Scholar 

  • Taniguchi T, Ohno S, Fuji-Kuriyama Y, Muramatsu M (1980b) The nucleotide sequence of human fibroblast interferon cDNA. Gene 10:11–15

    PubMed  CAS  Google Scholar 

  • Tomita Y, Kuwata T (1981) Suppressive effects of interferon on cell fusion by Sendai virus. J Gen Virol 55:289–295

    PubMed  CAS  Google Scholar 

  • Valle MJ, Jordan GW, Haahr S, Merigan TC (1975) Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons. J Immunol 115:230–233

    PubMed  CAS  Google Scholar 

  • Van’t Hull E, Schellekens H, Lowenberg B, De Vries MJ (1978) Influence of interferon preparations on the proliferative capacity of human and mouse bone marrow cells in vitro. Cancer Res 38:911–914

    Google Scholar 

  • Vilcek J, Gresser I, Merigan TC (1980a) Regulatory functions of interferons. Ann NY Acad Sci 350:1–157

    Google Scholar 

  • Vilcek J, Sulea IT, Zerebeckyj IL, Yip YK (1980b) Pharmacokinetic properties of human fibroblast and leukocyte interferon in rabbits. J Clin Microbiol 11:102–105

    PubMed  CAS  Google Scholar 

  • Vilcek J, Yip YK, Pang RHL, Kimberly T, Henriksen D, Zerebeckyj-Eckhardt I, Urban C, Taniguchi T (1981) How many interferons are there. Miami Winter Symp 18:331–345

    CAS  Google Scholar 

  • Virelizier JL, Allison AC, De Maeyer E (1977) Production by mixed lymphocyte cultures of a type II interferon able to protect macrophages against virus infection. Infect Immun 17:282–285

    PubMed  CAS  Google Scholar 

  • Ware CF, Granger GA (1979) A physicochemical and immunological comparison of the cell growth inhibitory activity of human lymphotoxins and interferons in vitro. J Immunol 122:1763–1768

    PubMed  CAS  Google Scholar 

  • Weck PK, Apperson S, May L, Stebbing N (1981a) Comparison of the antiviral activities of various cloned human interferon-alpha subtypes in mammalian cell cultures. J Gen Virol 57:233–237

    PubMed  CAS  Google Scholar 

  • Weck PK, Apperson S, Stebbing N, Gray PW, Leung D, Shepard HM, Goeddel DV (1981b) Antiviral activities of hybrids of two major human leukocyte interferons. Nucleic Acids Res 9:6153–6166

    PubMed  CAS  Google Scholar 

  • Weck PK, Rinderknecht E, Estell DA, Stebbing N (1982) Antiviral activity of bacteria derived human leukocyte interferons against EMC virus infection of mice. Infect Immun 35:660–665

    PubMed  CAS  Google Scholar 

  • Weissmann C(1981) The cloning of interferon and other mistakes. In: Gresser I (ed) Interferon. Academic, London, p 101

    Google Scholar 

  • Wetzel R(1981) Assignment of the disulfide bonds on leukocyte interferon. Nature 289:606–607

    PubMed  CAS  Google Scholar 

  • Wheelock EF (1965) Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. Science 149:310–311

    CAS  Google Scholar 

  • Williams CK, Svet-Moldavskaya, Vilcek J, Ohnuma T, Holland JF (1981) Inhibitory effects of human leukocyte and fibroblast interferons on normal and chronic myelogenous leukemic granulocytic progenitor cells. Oncology 38:356–360

    PubMed  CAS  Google Scholar 

  • Wiranowska-Stewart M (1981) Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon. J Interferon Res 1:315–322

    PubMed  CAS  Google Scholar 

  • Wiranowska-Stewart M, Stewart WE II (1981) Interferons: types alpha, beta and gamma. In: Hadden JW, Stewart WE II (eds) Lymphokines: Biochem Biol Act. Humana, Clifton, p 133

    Google Scholar 

  • Wiranowska-Stewart M, Lin LS, Brande IA, Stewart WE II (1980) production, partial purification and characterization of human and murine interferons type II. Mol Immunol 17:625–633

    PubMed  CAS  Google Scholar 

  • Yamaguchi T, Handa K, Shimizu Y, Abo T, Kumagai K (1977) Target cell for interferon production in human leukocytes stimulated by Sendai virus. J Immunol 118:1931–1946

    PubMed  CAS  Google Scholar 

  • Yelverton E, Leung D, Weck P, Gray PW, Goeddel DV (1981) Bacterial synthesis of a novel human leukocyte interferon. Nucleic Acids Res 9:731–741

    PubMed  CAS  Google Scholar 

  • Yip YK, Pang RH, Oppenhein JD, Nachbar MS, Henricksen D, Zerebeckyj-Eckhardt I, Vilcek J (1981a) Stimulation of human gamma interferon production by diterpene esters. Infect Immun 34:131–139

    PubMed  CAS  Google Scholar 

  • Yip YK, Pang RHL, Urban C, Vilcek J (1981b) Partial purification and characterization of human gamma (immune) interferon. Proc Natl Acad Sci USA 78:1601–1605

    PubMed  CAS  Google Scholar 

  • Zarling JM (1981) Enhancement of human cytotoxic T cell responses and NK cell activity by purified fibroblast interferon and polynucleotide inducers of interferon. Prog Cancer Res Ther 19:167–180

    CAS  Google Scholar 

Download references

Authors
  1. P. K. Weck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. E. Came
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. HEM Research Inc., 12280 Wilkins Avenue, Rockville, MD, 20852, USA

    Paul E. Came Ph.D.

  2. Clinical Research, Department of Oncology, Orlowitz Cancer Institute, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

  3. Department of Hematology and Oncology, Hahnemann University of Health Sciences, 230 North Broad Street, Philadelphia, PA, 19102, USA

    William A. Carter M.D. (Professor and Director) (Professor and Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Weck, P.K., Came, P.E. (1984). Comparative Biologic Activities of Human Interferons. In: Came, P.E., Carter, W.A. (eds) Interferons and Their Applications. Handbook of Experimental Pharmacology, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69178-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69178-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69180-5

  • Online ISBN: 978-3-642-69178-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation