Comparative Evaluation of Barbiturate and CA++Antagonist Attenuation of Brain Free Fatty Acid Liberation During Global Brain Ischemia
Whole brain fatty acids (FFA) increase rapidiy and continue to rise even after prolonged durations of complete global ischemia with a time course and magnitude unlike that of any other cerebral metabolite known thus far (4,5). Therefore, we hypothesized that brain FFA accumulation may reflect the evolution of ischemic brain injury at least during complete global ischemia. If so, drugs effective in improving the tolerance of the brain to ischemic anoxic insults such as the barbiturates (1,2) should attenuate the liberation of FFAs. Accordingly, pentobarbital anesthesia signficantly attenuated whole brain FFA liberation with more pronounced effects as the duration of ischemia was prolonged (4,5). This finding provided the first evidence of a metabolic basis for barbiturate-improved tolerance of the brain to complete global ischemia.
KeywordsIschemia Attenuation Lipase Sponge Ketamine
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