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Sex Chromosome Expression in Embryonic Development

  • Chapter
Mechanisms of Gonadal Differentiation in Vertebrates

Abstract

In this article we shall be concerned with two topics relating to sex chromosome expression during embryonic development: the onset of expression of the X and Y chromosomes during the preimplantation period of embryogenesis, and the cycle of inactivation and reactivation of the second X chromosome in female embryonic and germinal cells. To date, all of the information pertinent to these subjects has been derived from analysis of products coded for or controlled by the sex chromosomes. However, it is likely that molecular genetic approaches will be used in the future to amplify and extend the conclusions presented here.

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References

  1. Adler DA, West JD, Chapman VM (1977) Expression of α-ga-lactosidase in preimplantation mouse embryos. Nature 267:838–839.

    Article  PubMed  CAS  Google Scholar 

  2. Billington WD, Jenkinson EJ, Searle RF, Sellens MH (1977) Alloantigen expression during early embryogenesis and placen-tal ontogeny in the mouse: immunoperoxidase and mixed hem-adsorption studies. Transplant Proc 9:1371–1377.

    PubMed  CAS  Google Scholar 

  3. Burgoyne PS, Biggers JD (1976) The consequences of X-dosage deficiency in the germ line: Inpaired development in vitro of preimplantation embryos from XO mice. Develop Biol 51:109–117.

    Article  PubMed  CAS  Google Scholar 

  4. Cozad KM, Warner CM (1981) Specificity of H-2 antigens expressed on mouse blastocysts. J Exptl Zool 218:313–320.

    Article  CAS  Google Scholar 

  5. Epstein CJ (1970) Phosphoribosyltransferase activity during early mammalian development. J Biol Chem 245:3289–3294.

    PubMed  CAS  Google Scholar 

  6. Epstein CJ (1972) Inactivation of the X chromosome. N Engl J Med 286:318–319.

    Article  PubMed  CAS  Google Scholar 

  7. Epstein CJ (1981) Inactivation of the X chromosome. In: Ritzén M, Aperia A, Hall K, Larsson A, Zetterberg A, Zetter-ström R (eds) The biology of normal human growth. Raven Press, New York, p 79–90.

    Google Scholar 

  8. Epstein CJ (to be published) Cellular consequences of the state of X chromosome activity. In: Sandberg AA (ed) The cytogen-etics of the mammalian X chromosome. AR Liss, New York.

    Google Scholar 

  9. Epstein CJ (to be published) The X chromosome in development. In: Sandberg AA (ed) The cytogenetics of the mammalian X chromosome. AR Liss, New York.

    Google Scholar 

  10. Epstein CJ, Smith S, Travis B, Tucker G (1978) Both X chromosomes function before visible X chromosome inactivation in female mouse embryos. Nature 274:500–503.

    Article  PubMed  CAS  Google Scholar 

  11. Epstein CJ, Smith S, Travis B (1980) Expression of H-Y antigen on preimplantation mouse embryos. Tissue Antigens 15:63–67.

    Article  PubMed  CAS  Google Scholar 

  12. Ferguson-Smith MA (1965) Karyotype-phenotype correlation in gonadal dysgenesis and their bearing on the pathogenesis of malformations. J Med Genet 2:142–155.

    Article  PubMed  CAS  Google Scholar 

  13. Johnson MH (1981) The molecular and cellular basis of preimplantation mouse development. Biol Rev 56:463–498.

    Article  PubMed  CAS  Google Scholar 

  14. Krco CJ, Goldberg EH (1976) H-Y (male) antigen: detection on 8-cell embryos. Science 193:1134–1135.

    Article  PubMed  CAS  Google Scholar 

  15. Krco CJ, Goldberg EH (1977) Major histocompatibility antigens on preimplantation mouse embryos. Transplant Proc 9:1367–1370.

    PubMed  CAS  Google Scholar 

  16. Levinson J, Goodfellow P, Vadebonceur M, McDevitt H (1978) Identification of stage-specific polypeptides synthesized during murine preimplantation development. Proc Natl Acad Sci USA 75:3332–3336.

    Article  PubMed  CAS  Google Scholar 

  17. Luthardt FW (1976) Cytogenetic analysis of oocytes and early preimplantation embryos from XO mice. Develop Biol 54:73–81.

    Article  PubMed  CAS  Google Scholar 

  18. Lyon MF (1970) Genetic activity of sex chromosomes in somatic cells of mammals. Phil Trans Roy Soc Lond [Biol] 259:41–52.

    Article  CAS  Google Scholar 

  19. Lyon MF, Hawker SG (1973) Reproductive lifespan in irradiated and unirradiated chromosomally XO mice. Genet Res 21:185–194.

    Article  PubMed  CAS  Google Scholar 

  20. Magenis E, Brown M, Donlon T, Bangs D, Allen L, Bigley R, Koler R (1982) X-inactivation dogma revisited: dosage effect of G6PD in an infant with inverted duplication of the X distal long arm, 46X inv dup (X) (qter→ q26). Am J Hum Genet 34:134A.

    Google Scholar 

  21. Magnuson T, Epstein CJ (1981) Genetic control of very early mammalian development. Biol Rev 56:369–408.

    Article  PubMed  CAS  Google Scholar 

  22. Magnuson T, Epstein CJ (1981) Characterization of concanav-alin A precipitated proteins from early mouse embryos: A 2-di-mensional gel electrophoresis study. Develop Biol 81:193–199.

    Article  PubMed  CAS  Google Scholar 

  23. Magnuson T, Smith S, Epstein CJ (1982) Development of monosomy 19 mouse embryos. J Embryol Exptl Morphol 69:223–236.

    CAS  Google Scholar 

  24. Mikamo K, Aguereif M, Hazeghi P, Martin-DuPan R (1968) Chromatin-positive Klinefelter’s syndrome. A quantitative analysis of spermatogonial deficiency at 3, 4, and 12 months of age. Fertility Sterility 19:731–799.

    CAS  Google Scholar 

  25. Monk M, Harper MI (1979) Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos. Nature 281:311–313.

    Article  PubMed  CAS  Google Scholar 

  26. Muggleton-Harris AL, Johnson MH (1976) The nature and distribution of serologically detectable alloantigens on the preimplantation mouse embryo. J Embryol Exptl Morphol 35:59–72.

    CAS  Google Scholar 

  27. Müller U (1981) H-Y and antigens of the major histocompatibility complex. H-Y and H2-D antigens are associated on unfixed lymphocytes and thymocytes but not on testicular cells. Tissue Antigens 18:40–50.

    Article  PubMed  Google Scholar 

  28. Müller U, Mayerová A, Siebers JW, Wolf U (1980) Phenotypic conversion of human erythrocytes by H-Y antigens. Hum Genet 56:177–181.

    Article  PubMed  Google Scholar 

  29. Ohno S (1979) Major sex determining genes. Springer-Verlag, New York.

    Google Scholar 

  30. Sawicki JA, Epstein CJ (1981) H-2 antigens as genetic markers: a two-dimensional gel electrophoretic study. Immunogenetics 12:141–151.

    Article  PubMed  CAS  Google Scholar 

  31. Sawicki JA, Magnuson T, Epstein CJ (1981) Evidence for expression of the paternal genome in the two-cell mouse embryo. Nature 294:450–451.

    Article  PubMed  CAS  Google Scholar 

  32. Tarkowski A (1977) In vitro development of haploid mouse embryos produced by dissection of one-cell fertilized eggs. J Embryol Exptl Morphol 38:187–202.

    Google Scholar 

  33. White KL, Lindner GM, Anderson GB, BonDurant RH (1982) Survival after transfer of sexed mouse embryos emposed to H-Y antisera. Theriogenology 17:112.

    Article  Google Scholar 

  34. Wolf U, Fraccaro M, Mayerová A, Hecht T, Zuffardi O, Ha-meister H (1980) Turner syndrome patients are H-Y positive. Hum Genet 54:315–318.

    Article  PubMed  CAS  Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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Epstein, C.J. (1983). Sex Chromosome Expression in Embryonic Development. In: Mechanisms of Gonadal Differentiation in Vertebrates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69150-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-69150-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12480-1

  • Online ISBN: 978-3-642-69150-8

  • eBook Packages: Springer Book Archive

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