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4-Aminopyridine: An Anticurare and Reawakening Drug

  • E. Malizia
  • P. Nicolai
  • R. Romano
  • G. Pinto
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)

Abstract

4-Aminopyridine has been used experimentally in the reawakening phase of general anaesthesia induced by two different procedures: neuroleptanalgesia type II, using fentanyl and droperidol and midazolan-ketamine ataranalgesia. Both groups were curarized with a nondepolarizing drug: pancuronium bromide. A rapid decurarization and in the subjects of the second group a remarkable shortening of the time to awakening has been observed after 4-aminopyridine administration.

Key words

4-Aminopyridine Anticurare and reawakening effect 

References

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • E. Malizia
    • 1
  • P. Nicolai
    • 1
  • R. Romano
    • 1
  • G. Pinto
    • 1
  1. 1.Institute of Anesthesiology and ResuscitationRome University “La Sapienza” Medical SchoolRomeItaly

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