4-Aminopyridine: An Anticurare and Reawakening Drug
4-Aminopyridine has been used experimentally in the reawakening phase of general anaesthesia induced by two different procedures: neuroleptanalgesia type II, using fentanyl and droperidol and midazolan-ketamine ataranalgesia. Both groups were curarized with a nondepolarizing drug: pancuronium bromide. A rapid decurarization and in the subjects of the second group a remarkable shortening of the time to awakening has been observed after 4-aminopyridine administration.
Key words4-Aminopyridine Anticurare and reawakening effect
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