Neurotoxicity in Rats Dosed with Peppermint Oil and Pulegone

  • P. Olsen
  • I. Thorup
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)

Abstract

Rats dosed with peppermint oil and pulegone up to 100 or 160 mg/kg body weight/day, respectively, in 28 days developed encephalopathy. Microscopically dose-related cyst-like spaces were found in the white matter of the cerebellum.

Key words

Peppermint oil Pulegone Food flavouring Encephalopathy Rats 

References

  1. Greenhalgh P (1979) The markets for mint oils. Tropical Products Institute, London, pp 1–44Google Scholar
  2. Kennedy GL Jr, Dressier IA, Richter WR, Keplinger ML, Calandra JA (1976) Effects of hexachlorophene in the rat and their reversibility. Toxicol Appl Pharmacol 35: 137–145PubMedCrossRefGoogle Scholar
  3. Morison Smith D, Levi L (1961) Essential oils treatment of compositional data for the characterization of essential oils. Determination of geographical origins of peppermint oils by gas chromatographic analysis. Agric Food Chem 9: 230–244CrossRefGoogle Scholar
  4. Thorup I, Würtzen G, Carstensen J (1983) Short term toxicity study in rats dosed with peppermint oil. Toxicology Letters 19:211–215PubMedCrossRefGoogle Scholar
  5. Thorup J, Würtzen G, Carstensen J, Olsen P (1983) Short term toxicity study in rats dosed with pulegone and menthol. Toxicology Letters 19: 207–210PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • P. Olsen
    • 1
  • I. Thorup
    • 1
  1. 1.Institute of ToxicologyNational Food InstituteSøborg, CopenhagenDenmark

Personalised recommendations