Neurotoxicity in Rats Dosed with Peppermint Oil and Pulegone

  • P. Olsen
  • I. Thorup
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)


Rats dosed with peppermint oil and pulegone up to 100 or 160 mg/kg body weight/day, respectively, in 28 days developed encephalopathy. Microscopically dose-related cyst-like spaces were found in the white matter of the cerebellum.

Key words

Peppermint oil Pulegone Food flavouring Encephalopathy Rats 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • P. Olsen
    • 1
  • I. Thorup
    • 1
  1. 1.Institute of ToxicologyNational Food InstituteSøborg, CopenhagenDenmark

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