Interaction of Acrylonitrile with the Liver Mixed Function Oxidases
The effect on the liver mixed function oxidases of acrylonitrile revealed an inhibition of the benzo(a)pyrene hydroxylase and of the epoxide hydrase whereas aniline hydroxylase is unaffected. These findings exclude the possibility that the inhibitory effect of certain hydroxylation activities of the liver microsomes can be secondary to a direct effect of acrylonitrile on cytochrome P-450 but suggest the hypothesis that the inhibition is mediated by the cyanide released during acrylonitrile metabolism.
Key wordsAcrylonitrile Metabolism Reactive intermediates Liver Mixed function oxidases
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