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Effects of an Indenopyridine Derivative, Compound 20–438, on Spermatogonial Stem Cells of the Rat

  • K. E. Suter
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)

Abstract

Single high doses of the antitesticular compound 20–438 caused pronounced testis weight loss in rats. Treatment of adult testes containing fully populated tubules led to irreversible weight losses, indicative of damage to the spermatogonial stem cells. On the other hand, treatment of lightly populated tubules in either juventile testes or adult, cryptorchid testes also caused weight losses, but these were followed by substantial recovery. The fact that the damage induced by 20–438 in spermatogonial stem cells is related to the germ cell density points to the possibility that this compound acts by reducing the availability of an essential substrate.

Key words

Antispermatogenic compound Rat 

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References

  1. Clegg EJ (1963) Studies on artificial cryptorchidism: Degenerative and regenerative changes in the germinal epithelium of the rat testis. J Endocrinol 27: 241–251PubMedCrossRefGoogle Scholar
  2. Hodel C, Suter KE (1978) Reversible inhibition of spermatogenesis with an indenopyridine derivative (20–438). Arch Toxicol [Suppl] 1: 323–326CrossRefGoogle Scholar
  3. Matter BE, Jaeger I, Suter W, Tsuchimoto T, Deyssenroth H (1979) Actions of an antisperma-togenic, but non-mutagenic indenopyridine derivative in mice and salmonella typhimurum. Mutat Res 66:113–127PubMedCrossRefGoogle Scholar
  4. Suter KE, Donatsch P (1981) Effect of the antitesticular compound 20–438 on testicular fluid production and blood volume in rats. Teratology 24: 50AGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • K. E. Suter
    • 1
  1. 1.Preclinical ResearchSandoz Ltd.BaselSwitzerland

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