Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats

  • M. Vacca
  • P. Preziosi
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 7)

Abstract

Cisplatinum given intravenously (i.V.), hydroxyurea given orally (os), procarbazine (os) and L-asparaginase (i.V.), on a decreasing scale, produce significant (p< 0.01) adrenocortical activation over 4-h period at a single dose per kg 10 times higher than those employed in human therapy. Only hydroxyurea retained this activity after a 5-day treatment both in normal and Walker carcinosarcoma-bearing rats. Adrenocortical activation depends on the presence of pituitary ACTH both after single or repeated treatments.

Key words

L-Asparaginase Cisplatinum Hydroxyurea Procarbazine ACTH Hypothalamus-hypophyseal-adrenal axis Adrenal cortex -Cancer chemotherapy Drug effects Tolerance Walter carcinosarcoma 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. Vacca
    • 1
  • P. Preziosi
    • 1
  1. 1.Department of PharmacologyMedical Faculty of the Catholic University of the Sacred HeartRomeItaly

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