Abstract
Cisplatinum given intravenously (i.V.), hydroxyurea given orally (os), procarbazine (os) and L-asparaginase (i.V.), on a decreasing scale, produce significant (p< 0.01) adrenocortical activation over 4-h period at a single dose per kg 10 times higher than those employed in human therapy. Only hydroxyurea retained this activity after a 5-day treatment both in normal and Walker carcinosarcoma-bearing rats. Adrenocortical activation depends on the presence of pituitary ACTH both after single or repeated treatments.
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© 1984 Springer-Verlag
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Vacca, M., Preziosi, P. (1984). Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_11
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DOI: https://doi.org/10.1007/978-3-642-69132-4_11
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