Abstract
The brain, the chief target organ for psychiatry, has up to now been studied through approaches that were necessarily indirect. Blood, urine, and cerebrospinal fluid, though valuable indicators of neurochemical and neuropharmacological activity, are removed in time and place from the disordered thought and diluted by the products of both functional and dysfunctional systems. New technologies are now making possible a specific regional approach to patients with the major psychoses. These include 133 Xe blood flow, EEG and evoked potential topography, X-ray transmission scanning (CAT or CT Scans), nuclear magnetic resonance (NMR) imaging, and positron emission tomography (PET). These techniques so far have been more widely applied in schizophrenia than in affective illness, but competing regional hypotheses in dicate the need to apply these new regional approaches in depression.
Keywords
- Positron Emission Tomography
- Nuclear Magnetic Resonance
- Cerebral Blood Flow
- Globus Pallidus
- Research Technique
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Brownell, G.L.; Budinger, T.F.; Lautebur, P.C; and McGeer, P.L. 1982. Positron tomography and nuclear magnetic resonance imaging. Science 215: 619–626.
Bruder, G.; Sutton, S.; Berger-Gross, P.; Quitkin, M,; and Davies, S. 1981. Lateralized auditory processing in depression: Dichotic click detection. Psychiat. Res. 4:253–266.
Buchsbaum, M.S.; Davis, G.C.; Coppola, R.; and Naber, R. 1981a. Opiate pharmacology and individual differences. I. Psychophysical pain measurements. Pain 10: 357–366.
Buchsbaum, M.S.; Davis, G.C.; Coppola, R.; and Naber, R. 1981b. Opiate pharmacology and individual differences. II. Somatosensory evoked potentials. Pain 10: 367–377.
Buchsbaum, M.S.; Davis, G.C.; and van Kammen,D.P. 1980. Diagnostic classification and the endorphin hypothesis of schizophrenia: Individual differences and psychopharmacological strategies. In Perspectives in Schizophrenia Research, eds. C. Baxter and T. Melnechuk, pp. 177–194. New York: Raven Press.
Buchsbaum, M.S.; Gerner, R.; and Post, R.M. 1981. The effect of sleep deprivation on average evoked responses in depressed patients and in normals. Biol. Psychiat. 16: 351–363.
Buchsbaum, M.S., and Haier, R.J. 1978. Biological homogeneity, symptom heterogeneity, and the diagnosis of schizophrenia. Schizo phrenia Bull. 4: 473–475.
Buchsbaum, M.S.; Ingvar, D.H.; Kessler, R.; Waters, R.N.; Cappelletti, J.; van Kammen, D.P., King, A.C.; Johnson, J.; Manning, R.G.; Flynn,R.W.; Mann,L.S.; Bunney,Jr., W.E.; and Sokoloff, L. 1982. Cerebral glucography with positron tomography. Arch. Gen. Psychiat. 39:251–259.
Coleman, R.E.; Drayer,B.R; and Jaszczak, R.J. 1982. Studying regional brain function. 1982. J. Nucl. Med. 23: 266–270.
Comar, D.; Zarifian, E.; Verhas, M.; Soussaline, F.; Maziere, M.; Berger, G.; Loo, H.; Cuche, C; Kellersohn, C; and Deniker, P. 1979. Brain distribution and kinetics of 11C-Chloropromazine in schizophrenics. Psychiat. Res. 1: 23–29.
Davis, G.C., and Buchsbaum, M.S. 1981. Pain sensitivity and endorphins in functional psychoses. In Modern Problems of Pharmacopsychiatry, eds. T.A. Ban et al., pp. 99–108. Basel, Switzerland: Karger.
Davis, G.C.; Buchsbaum, M.S.; and Bunney,Jr., W.E. 1979. Analgesia to painful stimuli in affective illness. Am. J. Psychiat. 136: 1148– 1151.
Davis, G.C.; Buchsbaum, M.S.; and Bunney,Jr., W.E. 1979. Research in endorphins and schizophrenia. Schizophrenia Bull. 5: 244–250.
Davis, G.C.; Buchsbaum, M.S.; van Kammen, D.P.; and Bunney, Jr., W.E. 1979. Analgesia to pain stimuli in schizophrenics reversed by naltrexone. Psychiat. Res. 1:61–69.
Farkas, T.; Reivich, M.; Alavi, A.; Greenberg, J.H.; Fowler, J.S.; MacGregor, R.R.; Christman, D.R.; and Wolf,A.P. 1980. The application of 18F 2-Deoxy-2-FluoroD-Glucose and positron emission tomography in the study of psychiatric conditions. In Cerebral Metabolism and Neural Function, eds. J.V. Passonneau, R.A. Hawkins, W.D. Lust, and F.A. Welsh, pp. 403–408. Baltimore, MD: Williams and Wilkins.
Farkas, T.; Wolf, A.R; Jaeger, J.; Cancro, R.; Christman, D.; and Fowler, J. 1981. Regional cerebral glucose utilization in chronic schizophrenia. III World Congress of Biological Psychiatry. Symposium on Cerebral Circulation and Metabolism Related to Psychopathology, Stockholm, Sweden.
Fink, M. 1974. EEG profiles and bioavailability measures of psychoactive drugs. In Psychotropic Drugs and the Human EEG, ed. T.M. Itil. Basel, Switzerland: Karger.
Flor-Henry, P. 1979. On certain aspects of the localization of the cerebral systems regulating and determining emotion. Biol Psychiat. 14: 677–698.
Foit, A.; Larsen, B.; Hattori, S.; Skinhj, E.; and Lassen, N.A. 1980. Cortical activation during somatosensory stimulation and voluntary movement in man: A regional cerebral blood flow study. Electroenceph. Clin. Neurophysiol. 50: 426–436.
Franzen, G., and Ingvar, D.H. 1975. Absence of activation in frontal structures during psychological testing of chronic schizophrenics. J. Neurol. Neurosurg. Psychiat. 38: 1027–1032.
Greenberg, J.H.; Reivich, M.; Alavi, A.; Hand, P.; Rosenquist, A.; Rintelmann, W.; Stein, A.; Tusa, R.; Dann, R.; Christman, D.; Fowler, J.; MacGregor, B.; and Wolf, A. 1981. Metabolic mapping of functional activity in human subjects with the (18F) fluorodeoxyglucose technique. Science 212: 678–680.
Gustafson, L.; Risberg,J.; and Silfverskiold. P. 1981. Cerebral blood flow in dementia and depression. Lancet i: 275.
Hawkes, R.C; Holland, G.N.; Moore, W.S.; and Worthington, B.S. 1980. Nuclear magnetic resonance (NMR) tomography of the brain: A preliminary clinical assessment with demonstration of pathology. J. Comput. As. Tomog. 4: 577–586.
Hoyer, S., and Oesterreich, K. 1975. Blood flow and oxidase metabolism of the brain in patients with schizophrenia. Psychiat. CI. 8:304–313.
Ingvar, D.H. 1980. Abnormal distribution of cerebral activity in chronic schizophrenia; A neurophysiological interpretation. In Perspectives in Schizophrenia Research, eds. C.F. Baxter and T. Melnechuck, pp. 107–125. New York: Raven Press.
Ingvar, D.H., and Franzen, G. 1974. Distribution of cerebral activity in chronic schizophrenia. Lancet ii: 1484–1486.
Ingvar, D.H., and Philipson, L. 1977. Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance. Ann. Neurol. 2: 230–237.
Ingvar, D.H.; Rosen, I.; Eriksson, M.; and Elmqvist, D. 1976. Activation patterns induced in the dominant hemisphere by skin stimulation. In Sensory Functions of the Skin, ed. Y. Zotterman. London: Pergamon Press.
Jacoby, R.J., and Levy, R. 1980. Computed tomography in the elderly, III, Affective disorder. Br. J. Psychiat. 136: 270–275.
Jacoby, R.J.; Levy, R.; and Bird, J.M. 1981 Computed tomography and the outcome of affective disorder: A follow-up study of elderly pa tients. Br. J. Psychiat. 139: 288–292.
James, Jr., A.E.; Price, R.R.; Rollo, F.D.; Patton, J.A.; Erickson, J.J.; Coulam, CM.; and Partain,C.L. 1982. Nuclear magnetic resonance imaging: A promising technique. JAMA 247: 1331–1334.
Johnstone, E.C.; Crow, T.J.; Frith, CD.; Husband, J.; and Kreel, L. 1976. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet ii: 924–926.
Kety, S.S.; Woodford, R.B.; Harmel, M.H.; Freyhan, F.A.; Appel, K.E.; and Schmidt, CF. 1948. Cerebral blood flow and metabolism in schizophrenia. Am. J. Psychiat. 104: 765–770.
Kuhl, D.E.; Barrio, J.R.; Huang, S.C.; Selin,C.; Ackermann, R.F.; Lear, J.L.; Wu, J.L.; Lin,T.H.; and Phelps, M.E. 1982. Quantifying local cerebral blood flow by N-Isopropyl-p-[123]lodoamphetamine (IMP) tomography. J. Nuc. Med. 23: 196–203.
Mathew, R.J.; Duncan, G.C; Weinman, M.L.; Barr, D.L. 1982. Regional cerebral blood flow in schizophrenia: Arch. Gen. Psychiat. 39: 1121–1124.
Mathew, R.J.; Meyer, J.S.; Frances, D.J.; Semchuk, K.M.; Mortel, K.; and Claghorn, J.L. 1980. Cerebral blood flow in depression. Am. J. Psychiat. 137:1449–1450.
McCulloch, J.; Savaki, H.E., and Sokoloff, L. 1982. Distribution of effects of haloperidol on energy metabolism in the brain. Brain Res. 243: 81–90.
Oke, A.; Keller, R.; Mefford, L; and Adams, R.N. 1978. Lateralization of norepinephrine in human thalamus. Science 200: 1411–1413.
(39) Pearlson, G.D., and Veroff, A.E. 1982. Changes in computerized tomographic scan changes in manic depressive illness. Lancet i: 470.
Pert, A.; Everist, H.O.; Holcomb, H.H.; Kadkaro, M.; Gross, P.M.; and Sokoloff, L. 1983. Metabolic mapping of nigral connections with the 2-[14C] deoxyglucose method. Neurosci. Abstr., in press.
Phelps, M.E.; Huang, S.C.; Hoffman, E.J.; Selin,C.; Sokoloff, L.; and Kuhl, D.E. 1979. Tomographic measurements of local cerebral glucose metabolic rate in humans with [18F] 2-deoxy-D-glucose: Validation of method. Ann. Neurol. 6: 371–388.
Phelps, M.E.; Kuhl, D.E.; and Mazziotta, J.C. 1981. Metabolic mapping of the brain’s response to visual stimulation: Studies in humans. Science 211: 1445–1448.
Phelps, M.E.; Mazziotta, J.C; and Huang, S.C. 1982. Study of cerebral function with positron computed tomography. J. Cereb. Bl. Metab. 2: 113–162.
Phelps, M.E.; Mazziotta, J.C.; Kuhl, D.E.; Nuwer,M.; Packwood,J.; Metter, J.; and Engel, Jr., J. 1981. Tomographic mapping of human cerebral metabolism: Visual stimulation and deprivation. Neurol. 31: 517–529.
Risberg, J. 1980. Regional cerebral blood flow measurements by 133Xe-inhalation: Methodology and applications in neuropsychology and psychiatry. Brain Lang. 9: 9–34.
Roland, P.E. 1981. Somatotopical tuning of postcentral gyrus during focal attention in man. (A regional cerebral blood flow study.) J. Neurophysiol. 46: 744–754.
Ross, E.D., and Rush, A.J. 1981. Diagnosis and neuroanatomical correlates of depression in brain-damaged patients. Arch. Gen. Psychiat. 38: 1344–1354.
Rush, A.J.; Schlesser, M.A.; Stokely,E.; Bonte,F.R.; and Altshuler, K.Z. 1983. Cerebral blood flow in depression and mania. In Brain Imaging in Psychiatry and Neurology: Positron Emission Tomography and Other Techniques, eds. M.S. Buchsbaum, E. Usdin, W.E. Bunney, Jr., and D. Ingvar. Pacific Grove: Boxwood Press, in press.
Saletu, B.; Grunberger, J.; Linzmayer, L.; and Anderer, P. 1980. Classification and assessment of pharmacodynamics of SGD-SCHA 1059 (Binodine) by quantitative EEG and psychometric analyses. In Advances in Biological Psychiatry 4. Clinical Neurophysiological Aspects of Psychopathological Conditions, eds. C. Perris and L. van Knorring, pp. 140–166. Basel, Switzerland: S. Karger.
Savaki, H.E.; Desban, M.; Glowinski, J.; and Bosson, M.J. 1983. Local cerebral glucose consumption in the rat, part II: Effects of unilateral substantia nigra stimulation in conscious and in Halothane-anesthetized animals. Neurosci. Abstr., in press.
Shagass, C; Roemer, R.A.; and Straumanis, J.J. 1983. Relationships between psychiatric diagnosis and some quantitative EEG variables. Arch. Gen. Psychiat., in press.
Siesjo, B.K., ed. 1978. Brain Energy Metabolism. New York: Wiley Interscience Publication.
Silfverskiold, P.; Gustafson, L.; Johansson, B. A.; and Risberg, J. 1983. RCBF in Affective Disorders. In Brain Imaging in Psychiatry and Neurology: Positron Emission Tomography and Other Techniques, eds. M.S. Buchsbaum, E. Usdin, W.E. Bunney, Jr., and D. Ingvar. Pacific Grove: Boxwood Press, in press.
Sokoloff, L. 1981. Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed. Proc. 40:2311–2316.
Sokoloff, L. 1982. The radioactive deoxyglucose method. In Advances in Neurochemistry, pp. 1–81. New York: Plenum Publishing Corporation.
Sokoloff, L.; Reivich, M.; Kennedy, C; Des Rosier, M.H.; Patlack, C.S.; Pettigrew, K.D.; Saukurada, O.; and Shinohara, M. 1977. The [14C] Deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized rat. J. Neurochem. 28: 897–916.
Tsubokawa, T.; Katayama, Y.; Ueno, Y.; and Moriyasu, N. 1981. Evi dence for involvement of the frontal cortex in pain-related cerebral events in cats: increase in local cerebral blood flow by noxious stimuli. Brain Res. 217: 179–185.
Weinberger, D.R.; Delisi, L.E.; Neophytides, A.N.; and Wyatt, R.J. 1981. Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiat. Res. 4: 65–71.
Weinberger, D.F.; Torrey, E.F.; Neophytides, A.N.; and Wyatt, R.J. 1979. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch. Gen. Psychiat. 36: 935.
Wooten, G.F., and Collins, R.C. 1981. Metabolic effects of unilateral lesion of the substantia nigra. J. Neurosci. 1: 285–291.
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Buchsbaum, M.S., Holcomb, H.H. (1983). New Research Techniques for Studying the Functional Anatomy of Depression. In: Angst, J. (eds) The Origins of Depression: Current Concepts and Approaches. Dahlem Workshop Reports Life Sciences Research Report, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69129-4_17
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DOI: https://doi.org/10.1007/978-3-642-69129-4_17
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