Abstract
Changes in hormone dynamics occur in some patients with endogenous depression. These include hypersecretion of ACTH and Cortisol, nonsuppression of Cortisol by dexamethasone, blunted TSH response to TRH, reduced nocturnal GH secretion and GH responses to several secretory stimuli, reduced secretion of gonadotropins and gonadal steroids, and possible disturbances of other hormones as well. Some of these hormone changes may prove to be useful as ancillary laboratory aids in the differential diagnosis of endogenous depression and in the determination of the adequacy of treatment. These neuroendocrine changes also are relevant for etiology, in that both the affect disturbance and the endocrine changes may be sequelae of common CNS neurotransmitter dysfunctions. However, this hypothesis remains to be verified.
Keywords
- Depressed Patient
- Gonadal Steroid
- Depressive Illness
- Dexamethasone Suppression Test
- Neuroendocrine Function
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Rubin, R.T., Poland, R.E. (1983). Neuroendocrine Function in Depression. In: Angst, J. (eds) The Origins of Depression: Current Concepts and Approaches. Dahlem Workshop Reports Life Sciences Research Report, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69129-4_13
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DOI: https://doi.org/10.1007/978-3-642-69129-4_13
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