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Comparative Aspects of Amino Acid Ttansport in Guinea Pig, Rabbit and Rat Small Intestine

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Intestinal Transport

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

This chapter will deal mainly with the transport of cationic amino acids and imino acids, includingnon-a-monoaminocarboxylie acids across the brush-border membrane of the guinea pig, rabbit and rat small intestine. It will be based on data from ongoing research in my laboratory. The aim of this research is to resolve a number of the differences between current views on intestinal transport of amino acids. These differences exist mainly regarding the number of transport mechanisms for cationic and neutral amino acids both within and between species (Munck and Schultz 1969a,b, Preston et al. 1974, Munck and Rasmussen 1975, 1979, Paterson et al. 1979, 1980, 1981, Sepulveda and Smith 1978, Robinson and van Melle 1982), on the question of the stimulating effects of a number of neutral amino acids on the transport of cationic amino acids (Robinson and Felber 1964, Munck 1965, 1966b, 1980b, Munck and Schultz 1969b, Robinson and Alvarado 1977), and on the question of the transport of imino acids and non-a-neutral amino acids (Hagihira et al. 1961, Munck 1966a, Peterson et al. 1970, Sepulveda and Smith 1978, Stevens et al. 1982).

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References

  • Chez RA, Schultz SG, Curran PF (1966) Effect of sugars on transport of alanine in intestine. Science 153:1012–1013

    Article  PubMed  CAS  Google Scholar 

  • Christensen HN, Handlogten ME, Thomas El (1969) Na-facilitated reactions of neutral amino acids with a cationic amino acid transport system. Proc Natl Acad Sci USA 63:948–955

    Article  PubMed  CAS  Google Scholar 

  • Curran PF, Schultz SG, Chez RA, Fuisz RE (1967) Kinetic relations of the Na-amino acid interaction at the mucosal border of intestine. J Gen Physiol 50:1261–1286

    Article  PubMed  CAS  Google Scholar 

  • Daniels VG, Dawson AG, Newey H, Smyth DH (1969a) Effect of carbon chain length and amino group position on neutral amino acid transport systems in rat small intestine. Biochim Biophys Acta 173:575–577

    Article  PubMed  CAS  Google Scholar 

  • Daniels VG, Newey H, Smyth DH (1969b) Stereochemical specificity of neutral amino acid transfer systems in rat small intestine. Biochim Biophys Acta 183:637–639

    Article  PubMed  CAS  Google Scholar 

  • Goldner AM, Sarracino S, Estep JA (1977) Coupling of sodium and substrate fluxes in the intestine: galactose transport in the jejunum. In: Kramer M, Lauterbach F (eds) Intestinal permeation. Excerpta Medica, Amsterdam Oxford, p 282

    Google Scholar 

  • Gunter-Smith PJ, Grasset E, Schultz SG (1982) Sodium-coupled amino acid and sugar transport by Nec turns small intestine: An equivalent electrical circuit analysis of a rheogenic co transport system. J Membr Biol 66:25–39

    Article  PubMed  CAS  Google Scholar 

  • Hagihira H, Lin ECC, Samiy AH, Wilson TH (1961) Active transport of lysine, ornithine, arginine and cystine by the intestine. Biochem Biophys Res Commun 4:478–481

    Article  PubMed  CAS  Google Scholar 

  • Hagihira H, Wilson TH, Lin ECC (1962) Intestinal transport of certain N-substituted amino acids. Am J Physiol 203:637–640

    PubMed  CAS  Google Scholar 

  • Lerner J, Karcher CA (1978) Kinetic properties of imino acid transport system in the chicken intestine. Comp Biochem Physiol 60A:503–505

    Article  CAS  Google Scholar 

  • Mircheff AK, Os CH van, Wright EM (1980) Pathways for alanine transport in intestinal basal lateral membrane vesicles. J Membr Biol 52:83–92

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1965) Amino acid transport by the small intestine of the rat. The effect of amino acid pre-loading on the transintestinal amino acid transport by the everted sac preparation. Biochim Biophys Acta 109:142–150

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1966a) Amino acid transport by the small intestine of the rat. The existence and specificity of the transport mechanism of imino acid and its relation to the transport of glycine. Biochim Biophys Acta 120:97–103

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1966b) Amino acid transport by the small intestine of the rat. On the counterflow phenomenon as a cause of the accelerating effect of leucine on the trans-intestinal transport of diamino acids. Biochim Biophys Acta 120:282–291

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1968) Amino acid transport by the small intestine of the rat. Evidence against interactions between sugars and amino acids at the carrier level. Biochim Biophys Acta 156:192–194

    Google Scholar 

  • Munck BG (1972) Effects of sugar and amino acid transport on transepithelial fluxes of sodium and chloride of short circuited rat jejunum. J Physiol (Lond) 223:699–717

    CAS  Google Scholar 

  • Munck BG (1977) Intestinal transport of amino acids. In: Kramer M, Lauterbach F (eds) Intestinal permeation, vol IV. Excerpta Medica, Amsterdam, p 123

    Google Scholar 

  • Munck BG (1980a) Transport of sugars and amino acids across guinea pig small intestine. Biochim Biophys Acta 597:411–417

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1980b) Lysine transport across the small intestine. Stimulating and inhibitory effects of neutral amino acids. J Membr Biol 53:45–53

    Article  PubMed  CAS  Google Scholar 

  • Munck BG (1981) Intestinal absorption of amino acids. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven Press, New York, p 1097

    Google Scholar 

  • Munck BG, Rasmussen SN (1975) Characteristics of rat jejunal transport of tryptophan. Biochim Biophys Acta 389:261–280

    Article  PubMed  CAS  Google Scholar 

  • Munck BG, Rasmussen SN (1979) Lysine transport across rat jejunum: Distribution between the transcellular and the paracellular routes. J Physiol (Lond) 291:291–303

    CAS  Google Scholar 

  • Munck BG, Schultz SG (1969a) Lysine transport across isolated rabbit ileum. J Gen Physiol 153: 157–182

    Article  Google Scholar 

  • Munck BG, Schultz SG (1969b) Interactions between leucine and lysine transport in rabbit ileum. Biochim Biophys Acta 183:182–193

    Article  PubMed  CAS  Google Scholar 

  • Murer H, Sigrist-Nelson K, Hopfer U (1975) On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem 250:7392–7396

    PubMed  CAS  Google Scholar 

  • Newey H, Smyth DH (1964) The transfer system for neutral amino acids in the rat small intestine. J Physiol 170:328–343

    PubMed  CAS  Google Scholar 

  • Okada Y, Tsuchiya W, Irimajiri A, Inouye A (1977) Electrical properties and active solute transport in rat small intestine. I. Potential profile changes associated with sugar and amino acid transport. J Membr Biol 31:205–219

    Article  PubMed  CAS  Google Scholar 

  • Oxender DL, Christensen HN (1963) Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J Biol Chem 238:3686–3699

    PubMed  CAS  Google Scholar 

  • Paterson JYF, Sepulveda FV, Smith MW (1979) Two carrier influx of neutral amino acids into rabbit ileal mucosa. J Physiol (Lond) 292:339–350

    CAS  Google Scholar 

  • Paterson JYF, Sepulveda FV, Smith MW (1980) A sodium-independent low affinity transport system for neutral amino acids in rabbit ileal mucosa. J Physiol (Lond) 298:333–346

    CAS  Google Scholar 

  • Paterson JYF, Sepulveda FV, Smith MW (1981) Distinguishing transport systems having overlapping specificities for neutral and basic amino acids in the rabbit ileum. J Physiol 319:345–354

    Google Scholar 

  • Peterson SC, Goldner AM, Curran PF (1970) Glycine transport in rabbit ileum. Am J Physiol 219:1027–1032

    PubMed  CAS  Google Scholar 

  • Preston RL, Schaeffer J-F, Curran PF (1974) Structure-affinity relationships of substrates for the neutral amino acid transport system in rabbit ileum. J Gen Physiol 64:443–467

    Article  PubMed  CAS  Google Scholar 

  • Reiser S, Christiansen PA (1969) A cross-inhibition of basic amino acid transport by neutral amino acids. Biochim Biophys Acta 183:611–624

    Article  PubMed  CAS  Google Scholar 

  • Reiser S, Christiansen PA (1971a) The properties of the preferential uptake of L-leucine by isolated intestinal epithelial cells. Biochim Biophys Acta 225:123–139

    Article  PubMed  CAS  Google Scholar 

  • Reiser S. Christiansen PA (1971b) Stimulation of basic amino acid uptake by certain neutral amino acids in isolated intestinal epithelial cells. Biochim Biophys Acta 241:102–113

    CAS  Google Scholar 

  • Reiser S, Christiansen A (1972) A basis for the difference in the inhibition of the uptake of various neutral amino acids by lysine in intestinal epithelial cells. Biochim BiophysActa 266: 217–229

    Article  PubMed  CAS  Google Scholar 

  • Reiser S, Christiansen PA (1973) Exchange transport and amino acid charge as the basis for Na+-independent lyseine uptake by isolated intestinal epithelial cells. Biochim Biophys Acta 307: 223–233

    Article  PubMed  CAS  Google Scholar 

  • Robinson JWL (1968) Interactions between neutral and dibasic amino acids for uptake by the rat intestine. Eur J Biochem 7:78–89

    Article  PubMed  CAS  Google Scholar 

  • Robinson JWL, Alvarado F (1977) Comparative aspects of the interactions between sugar and amino acid transport systems. In: Kramer M, Lauterbach F (eds) Intestinal permeation, vol IV. Excerpta Medica, Amsterdam Oxford, p 145

    Google Scholar 

  • Robinson JWL, Felber JP (1964) A survey of the effect of other amino-acids on the absorption of L-arginine and L-lysine by the rat intestine. Gastroenterology 101:330–338

    Article  CAS  Google Scholar 

  • Robinson JWL, Melle G van (1982) Single-site uptake of neutral amino acids into guinea-pig intestinal rings. J Physiol (Lond) 323:569–587

    CAS  Google Scholar 

  • Rose RC, Schultz SG (1971) Studies on the electrical potential profile across rabbit ileum. Effects of sugars and amino acids on transmural and transmucosal electrical potential differences. J Gen Physiol 57:639–663

    Article  PubMed  CAS  Google Scholar 

  • Schultz SG (1977) Sodium-coupled solute transport by small intestine: a status report. Am J Physiol 233:E249 - E254

    Google Scholar 

  • Schultz SG (1980) Basic principles of membrane transport. Cambridge Univ Press, New York

    Google Scholar 

  • Schultz SG (1981) Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by “flush-through”. Am J Physiol 241:F579-F590

    PubMed  CAS  Google Scholar 

  • Schultz SG, Curran PF, Chez RA, Fuisz RE (1967) Alanine and sodium fluxes across mucosal border of rabbit ileum. J Gen Physiol 50:1241–1260

    Article  PubMed  CAS  Google Scholar 

  • Sepulveda FV, Smith MW (1978) Discrimination between different entry mechanisms for neutral amino acids in rabbit ileal mucosa. J Physiol (Lond) 282:73–90

    CAS  Google Scholar 

  • Sepulveda FV, Smith MW (1979) Different mechanisms for neutral amino acid uptake by newborn pig colon. J Physiol (Lond) 286:479–490

    CAS  Google Scholar 

  • Spencer RP, Brody KR (1964) Intestinal transport of cyclic and noncyclic amino acids. Biochim Biophys Acta 88:400–406

    PubMed  CAS  Google Scholar 

  • Stevens BR, Ross HJ, Wright EM (1982) Multiple transport pathways for neutral amino acids in rabbit jejunal brush border vesicles. J Membr Biol 66:213–225

    Article  PubMed  CAS  Google Scholar 

  • Thomson ABR, Dietschy JM (1977) Derivation of the equations that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine. J Theoret Biol 64:277–294

    Article  CAS  Google Scholar 

  • Thomson ABR, Dietschy JM (1980) Experimental demonstration of the effect of the unstirred water layer on the kinetic constants of the membrane transport of D-glucose in rabbit ileum. J Membr Biol 54:221–229

    Article  PubMed  CAS  Google Scholar 

  • Ussing HH, Zerahn K (1951) Active transport of sodium as the source of electric current in the short-circuited frog skin. Acta Physiol Scand 214:110–127

    Article  Google Scholar 

  • White JF, Armstrong WMcD (1971) Effect of transported solutes on membrane potentials in bullfrog small intestine. Am J Physiol 221:194–201

    PubMed  CAS  Google Scholar 

  • Winne D (1973) Unstirred layer, source of biased Michaelis constant in membrane transport. Biochim Biophys Acta 298:27–31

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Physiology A, The Panum Institute Blegdamsvej 3C, DK-2200, Cøpenhagen N, Denmark

    B. G. Munck

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  1. B. G. Munck
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Editors and Affiliations

  1. Laboratory of General and Comparative Biochemistry, University of Liège, 17, Place Delcour, 4020, Liège, Belgium

    M. Gilles-Baillien (Scientific Editor) (Scientific Editor)

  2. Laboratory of Animal Physiology, University of Liège, 22, Quai Van Beneden, 4020, Liège, Belgium

    R. Gilles (Coordinating Editor) (Coordinating Editor)

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© 1983 Springer-Verlag Berlin Heidelberg

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Munck, B.G. (1983). Comparative Aspects of Amino Acid Ttansport in Guinea Pig, Rabbit and Rat Small Intestine. In: Gilles-Baillien, M., Gilles, R. (eds) Intestinal Transport. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69109-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-69109-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69111-9

  • Online ISBN: 978-3-642-69109-6

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