Radiologic Contrast Media

  • J.-P. Girard
  • L. Gamba
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 63)

Abstract

The radiographic contrast media currently used in diagnostic medicine are almost all derivatives of triiodobenzoic acid; they have frequently been found to cause unpredictable adverse reactions following intravascular application. As early as 1931, Horsters described a lethal anaphylactic reaction following intravenous injection of such a chemical. A large series of untoward reactions to contrast media was reported by Hultborn (1939), suggesting an allergic mechanism. Such a pathogenic hypothesis was later also proposed by several authors (Dolan 1940; Braunbehrens 1940; Pässler 1952). Up to now, however specific antibodies against contrast media have seldom been found (Bauer and Deutsch 1975; Kleinknecht et al. 1974) and delayed hypersensitivity mechanisms have never been demonstrated.

Keywords

Corticosteroid Iodine Hydrocortisone Aspirin Flare 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • J.-P. Girard
  • L. Gamba

There are no affiliations available

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